gonadorelin (Discontinued)

Brand and Other Names:Lutrepulse
  • Print

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

lyophilized powder for reconstitution

  • 0.8mg
  • 3.2mg

Primary Hypothalamic Amenorrhea

No longer available in the United States

Induction of ovulation: 5 mcg SC/IV q90min

Not applicable

Next:

Adverse Effects

Frequency Not Defined

Inj site reaction

Ovarian hyperstimulation

Thrombophlebitis

Previous
Next:

Warnings

Contraindications

Hypersensitivity to gonadorelin

Ovarian cysts

Hormonally-dependent tumors

Any condition potentially exacerbated by pregnancy

Cautions

Monitor ovarian function

Possibility of multiple gestation

Should be administered only by physician familiar with reproductive medicine & pulsatile LHRH/GnRH delivery

Previous
Next:

Pregnancy & Lactation

Pregnancy Category: X

Lactation: not recommended

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Previous
Next:

Pharmacology

Vd: 9-15 L

Half-Life, Initial: 2-10 min

Half-Life, Terminal: 10-40 min

Metabolism: to small peptides

Excretion: urine

Mechanism of Action

Recombinant human LHRH (GnRH)

Previous
Next:

Administration

IV/SC Preparation

Reconstitute aseptically with 8 mL of diluent provided (NS) immediately prior to use

Shake for a few seconds

IV/SC Administration

Administer using a pulsatile pump

Set to deliver 25 or 50 mcL based upon dose selected, over a pulse period of 1 min & a pulse frequency of 90 min

Previous
Next:

Images

Previous
Next:
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.