magnesium citrate (OTC)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

liquid

  • 290mg/5mL

tablet

  • 100mg (elemental)

Nutritional Supplementation

19-30 years: Men, 400 mg/day; women, 310 mg/day; pregnant women (≤50 years), 350 mg/day; breastfeeding women (≤50 years), 310 mg/day

>30 years: Men, 420 mg/day; women, 320 mg/day; pregnant women (≤50 years), 360 mg/day; breastfeeding women (≤50 years), 320 mg/day

Constipation/Bowel Evacuation

195-300 mL PO in single daily dose or in divided doses with full glass of water

Alternative: 2-4 tablets PO at bedtime

Acid Indigestion

1 tablet twice daily or as directed by healthcare provider

Dosage Forms & Strengths

liquid

  • 290mg/5mL

tablet

  • 100mg (elemental)

Constipation/Bowel Evacuation

<2 years: Safety and efficacy not established

2-6 years: 60-90 mL PO once or divided doses; not to exceed 90 mL/24hr

6-12 years: 90-210 mL in single dose or in divided doses with full glass of water

>12 years: 195-300 mL PO in single daily dose or in divided doses with full glass of water; alternatively, may administer 2-4 tablets PO at bedtime

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Interactions

Interaction Checker

and magnesium citrate

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            Adverse Effects

            Frequency Not Defined

            Abdominal cramping

            Diarrhea

            Electrolyte imbalance

            Hypermagnesemia

            Gas formation

            Nausea/vomiting

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            Warnings

            Contraindications

            Low sodium diet

            Cautions

            Use caution in renal insufficiency or magnesium-restricted diet

            For occasional use only in treatment of constipation

            Use with caution in patients with myasthenia gravis or other neuromuscular disease

            Should be refrigerated to maintain potency and palatability

            Avoid use in renal failure, existing electrolyte imbalance, appendicitis or acute surgical abdomen, myocardial damage or heart block, fecal impaction or rectal fissures, intestinal obstruction or perforation, dehydration

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            Pregnancy & Lactation

            Pregnancy category: A

            Lactation: Use in nursing mothers appears to be safe

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Increases peristaltic activity of the colon; promotes bowel evacuation by causing osmotic retention of fluid

            Absorption

            15-30% absorbed

            Onset: 0.5-6 hr or less

            Elimination

            Excretion: Urine (mainly)

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.