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      Drugs & Diseases

      cyclizine (OTC)

      Brand and Other Names:Marezine, Bonine for Kids, more...Cyclivert
      • Print

      Dosing & Uses

      AdultPediatricGeriatric

      Dosage Forms & Strengths

      tablet

      • 25mg
      • 50mg

      Motion Sickness

      Indicated for the prevention and treatment of nausea, vomiting and vertigo associated with motion sickness

      50 mg PO taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day

      Dosage Forms & Strengths

      tablet

      • 25mg
      • 50mg

      tablet, chewable

      • 25mg

      Motion Sickness

      Indicated for the prevention and treatment of nausea, vomiting and vertigo associated with motion sickness

      6-12 years: 25 mg PO up to 3 times/day; not to exceed 75 mg/day

      >12 years: 50 mg PO taken 30 minutes before departure, may repeat in 4-6 hr if needed, up to 200 mg/day

      Use lowest dose in divided doses in the elderly because of potential anticholinergic effects

      May cause confusion or aggravate symptoms of confusion in those with dementia; limit use if possible in the elderly

      Constipation and difficulty voiding urine may occur in the elderly

      Motion Sickness

      Indicated for the prevention and treatment of nausea, vomiting and vertigo associated with motion sickness

      50 mg PO taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day

      Next:

      Interactions

      Interaction Checker

      and cyclizine

      No Results

         activity indicator 
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        Interactions Found

        Contraindicated

          Serious - Use Alternative

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                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (4)

                  • calcium/magnesium/potassium/sodium oxybates

                    cyclizine, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                  • pramlintide

                    pramlintide, cyclizine. Either increases effects of the other by pharmacodynamic synergism. Contraindicated. Synergistic inhibition of GI motility.

                  • secretin

                    cyclizine decreases effects of secretin by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Concomitant use of anticholinergic drugs may cause a hyporesponse to stimulation testing with secretin. Discontinue anticholinergic drugs at least 5 half-lives before administering secretin.

                  • sodium oxybate

                    cyclizine, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

                  Monitor Closely (226)

                  • aclidinium

                    cyclizine and aclidinium both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • albuterol

                    cyclizine increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • alfentanil

                    cyclizine and alfentanil both increase sedation. Use Caution/Monitor.

                  • alprazolam

                    cyclizine and alprazolam both increase sedation. Use Caution/Monitor.

                  • amantadine

                    cyclizine, amantadine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Potential for increased anticholinergic adverse effects.

                  • amitriptyline

                    cyclizine and amitriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and amitriptyline both increase sedation. Use Caution/Monitor.

                  • amobarbital

                    cyclizine and amobarbital both increase sedation. Use Caution/Monitor.

                  • amoxapine

                    cyclizine and amoxapine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and amoxapine both increase sedation. Use Caution/Monitor.

                  • anticholinergic/sedative combos

                    anticholinergic/sedative combos and cyclizine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • apomorphine

                    cyclizine and apomorphine both increase sedation. Use Caution/Monitor.

                  • arformoterol

                    cyclizine increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • aripiprazole

                    cyclizine and aripiprazole both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of aripiprazole by pharmacodynamic antagonism. Use Caution/Monitor.

                    aripiprazole increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • armodafinil

                    cyclizine increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • atracurium

                    atracurium and cyclizine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • atropine

                    atropine and cyclizine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • atropine IV/IM

                    atropine IV/IM and cyclizine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • azelastine

                    azelastine and cyclizine both increase sedation. Use Caution/Monitor.

                  • baclofen

                    cyclizine and baclofen both increase sedation. Use Caution/Monitor.

                  • belladonna alkaloids

                    belladonna alkaloids and cyclizine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • belladonna and opium

                    cyclizine and belladonna and opium both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and belladonna and opium both increase sedation. Use Caution/Monitor.

                  • benperidol

                    cyclizine and benperidol both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of benperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of benperidol by pharmacodynamic antagonism. Use Caution/Monitor.

                    benperidol increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • benzphetamine

                    cyclizine increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • benztropine

                    benztropine and cyclizine both decrease cholinergic effects/transmission. Use Caution/Monitor. Additive anticholinergic adverse effects may be seen with concurrent use.

                  • bethanechol

                    bethanechol increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • brompheniramine

                    brompheniramine and cyclizine both increase sedation. Use Caution/Monitor.

                  • buprenorphine

                    cyclizine and buprenorphine both increase sedation. Use Caution/Monitor.

                  • buprenorphine buccal

                    cyclizine and buprenorphine buccal both increase sedation. Use Caution/Monitor.

                  • butabarbital

                    cyclizine and butabarbital both increase sedation. Use Caution/Monitor.

                  • butalbital

                    cyclizine and butalbital both increase sedation. Use Caution/Monitor.

                  • butorphanol

                    cyclizine and butorphanol both increase sedation. Use Caution/Monitor.

                  • caffeine

                    cyclizine increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • carbachol

                    carbachol increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • carbinoxamine

                    carbinoxamine and cyclizine both increase sedation. Use Caution/Monitor.

                  • carisoprodol

                    cyclizine and carisoprodol both increase sedation. Use Caution/Monitor.

                  • cevimeline

                    cevimeline increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • chloral hydrate

                    cyclizine and chloral hydrate both increase sedation. Use Caution/Monitor.

                  • chlordiazepoxide

                    cyclizine and chlordiazepoxide both increase sedation. Use Caution/Monitor.

                  • chlorpheniramine

                    chlorpheniramine and cyclizine both increase sedation. Use Caution/Monitor.

                  • chlorpromazine

                    cyclizine and chlorpromazine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of chlorpromazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of chlorpromazine by pharmacodynamic antagonism. Use Caution/Monitor.

                    chlorpromazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • chlorzoxazone

                    cyclizine and chlorzoxazone both increase sedation. Use Caution/Monitor.

                  • cinnarizine

                    cinnarizine and cyclizine both increase sedation. Use Caution/Monitor.

                  • cisatracurium

                    cisatracurium and cyclizine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • clemastine

                    clemastine and cyclizine both increase sedation. Use Caution/Monitor.

                  • clobazam

                    cyclizine, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

                  • clomipramine

                    cyclizine and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and clomipramine both increase sedation. Use Caution/Monitor.

                  • clonazepam

                    cyclizine and clonazepam both increase sedation. Use Caution/Monitor.

                  • clorazepate

                    cyclizine and clorazepate both increase sedation. Use Caution/Monitor.

                  • clozapine

                    cyclizine and clozapine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of clozapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of clozapine by pharmacodynamic antagonism. Use Caution/Monitor.

                    clozapine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • codeine

                    cyclizine and codeine both increase sedation. Use Caution/Monitor.

                  • cyclobenzaprine

                    cyclizine and cyclobenzaprine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and cyclobenzaprine both increase sedation. Use Caution/Monitor.

                  • cyproheptadine

                    cyclizine and cyproheptadine both increase sedation. Use Caution/Monitor.

                  • dantrolene

                    cyclizine and dantrolene both increase sedation. Use Caution/Monitor.

                  • darifenacin

                    cyclizine and darifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • desflurane

                    desflurane and cyclizine both increase sedation. Use Caution/Monitor.

                  • desipramine

                    cyclizine and desipramine both increase sedation. Use Caution/Monitor.

                  • dexchlorpheniramine

                    cyclizine and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

                  • dexfenfluramine

                    cyclizine increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dexmedetomidine

                    cyclizine and dexmedetomidine both increase sedation. Use Caution/Monitor.

                  • dexmethylphenidate

                    cyclizine increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dextroamphetamine

                    cyclizine increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dextromoramide

                    cyclizine and dextromoramide both increase sedation. Use Caution/Monitor.

                  • diamorphine

                    cyclizine and diamorphine both increase sedation. Use Caution/Monitor.

                  • diazepam

                    cyclizine and diazepam both increase sedation. Use Caution/Monitor.

                  • dicyclomine

                    cyclizine and dicyclomine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • diethylpropion

                    cyclizine increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • difenoxin hcl

                    cyclizine and difenoxin hcl both increase sedation. Use Caution/Monitor.

                  • dimenhydrinate

                    cyclizine and dimenhydrinate both increase sedation. Use Caution/Monitor.

                  • diphenhydramine

                    cyclizine and diphenhydramine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and diphenhydramine both increase sedation. Use Caution/Monitor.

                  • diphenoxylate hcl

                    cyclizine and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

                  • dipipanone

                    cyclizine and dipipanone both increase sedation. Use Caution/Monitor.

                  • dobutamine

                    cyclizine increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • donepezil

                    donepezil increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dopamine

                    cyclizine increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dopexamine

                    cyclizine increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dosulepin

                    cyclizine and dosulepin both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and dosulepin both increase sedation. Use Caution/Monitor.

                  • doxepin

                    cyclizine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and doxepin both increase sedation. Use Caution/Monitor.

                  • doxylamine

                    cyclizine and doxylamine both increase sedation. Use Caution/Monitor.

                  • droperidol

                    cyclizine and droperidol both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of droperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of droperidol by pharmacodynamic antagonism. Use Caution/Monitor.

                    droperidol increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • echothiophate iodide

                    echothiophate iodide increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ephedrine

                    cyclizine increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • epinephrine

                    cyclizine increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • epinephrine racemic

                    cyclizine increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • estazolam

                    cyclizine and estazolam both increase sedation. Use Caution/Monitor.

                  • ethanol

                    cyclizine and ethanol both increase sedation. Use Caution/Monitor.

                  • etomidate

                    etomidate and cyclizine both increase sedation. Use Caution/Monitor.

                  • fenfluramine

                    cyclizine increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • fesoterodine

                    cyclizine and fesoterodine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • flavoxate

                    cyclizine and flavoxate both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • fluphenazine

                    cyclizine and fluphenazine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of fluphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of fluphenazine by pharmacodynamic antagonism. Use Caution/Monitor.

                    fluphenazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • flurazepam

                    cyclizine and flurazepam both increase sedation. Use Caution/Monitor.

                  • formoterol

                    cyclizine increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • galantamine

                    galantamine increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • glycopyrrolate

                    cyclizine and glycopyrrolate both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • glycopyrrolate inhaled

                    cyclizine and glycopyrrolate inhaled both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • gotu kola

                    gotu kola increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • haloperidol

                    cyclizine and haloperidol both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of haloperidol by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of haloperidol by pharmacodynamic antagonism. Use Caution/Monitor.

                    haloperidol increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • hawthorn

                    hawthorn increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • henbane

                    cyclizine and henbane both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • homatropine

                    cyclizine and homatropine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • hops

                    hops increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • huperzine A

                    huperzine A increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • hyaluronidase

                    cyclizine decreases effects of hyaluronidase by Other (see comment). Use Caution/Monitor. Comment: Antihistamines, when given in large systemic doses, may render tissues partially resistant to the action of hyaluronidase. Patients may require larger amounts of hyaluronidase for equivalent dispersing effect.

                  • hydromorphone

                    cyclizine and hydromorphone both increase sedation. Use Caution/Monitor.

                  • hydroxyzine

                    cyclizine and hydroxyzine both increase sedation. Use Caution/Monitor.

                  • hyoscyamine

                    cyclizine and hyoscyamine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • hyoscyamine spray

                    cyclizine and hyoscyamine spray both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • iloperidone

                    cyclizine and iloperidone both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of iloperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of iloperidone by pharmacodynamic antagonism. Use Caution/Monitor.

                    iloperidone increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • imipramine

                    cyclizine and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and imipramine both increase sedation. Use Caution/Monitor.

                  • ipratropium

                    cyclizine and ipratropium both decrease cholinergic effects/transmission. Use Caution/Monitor. Due to the poor systemic absorption of ipratropium, interaction unlikely at regularly recommended dosages.

                  • isoproterenol

                    cyclizine increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • kava

                    kava increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • ketamine

                    ketamine and cyclizine both increase sedation. Use Caution/Monitor.

                  • ketotifen, ophthalmic

                    cyclizine and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

                  • levalbuterol

                    cyclizine increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • levodopa

                    cyclizine, levodopa. Other (see comment). Use Caution/Monitor. Comment: Anticholinergic agents may enhance the therapeutic effects of levodopa; however, anticholinergic agents can exacerbate tardive dyskinesia. In high dosage, anticholinergics may decrease the effects of levodopa by delaying its GI absorption. .

                  • levorphanol

                    cyclizine and levorphanol both increase sedation. Use Caution/Monitor.

                  • lisdexamfetamine

                    cyclizine increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lofepramine

                    cyclizine and lofepramine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and lofepramine both increase sedation. Use Caution/Monitor.

                  • lofexidine

                    cyclizine and lofexidine both increase sedation. Use Caution/Monitor.

                  • loprazolam

                    cyclizine and loprazolam both increase sedation. Use Caution/Monitor.

                  • lorazepam

                    cyclizine and lorazepam both increase sedation. Use Caution/Monitor.

                  • lormetazepam

                    cyclizine and lormetazepam both increase sedation. Use Caution/Monitor.

                  • loxapine

                    cyclizine and loxapine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of loxapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of loxapine by pharmacodynamic antagonism. Use Caution/Monitor.

                    loxapine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • loxapine inhaled

                    loxapine inhaled increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                    cyclizine and loxapine inhaled both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of loxapine inhaled by pharmacodynamic antagonism. Use Caution/Monitor.

                  • lurasidone

                    lurasidone, cyclizine. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

                  • maprotiline

                    cyclizine and maprotiline both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and maprotiline both increase sedation. Use Caution/Monitor.

                  • marijuana

                    cyclizine and marijuana both increase sedation. Use Caution/Monitor.

                  • meclizine

                    cyclizine and meclizine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • melatonin

                    cyclizine and melatonin both increase sedation. Use Caution/Monitor.

                  • meperidine

                    cyclizine and meperidine both increase sedation. Use Caution/Monitor.

                  • meprobamate

                    cyclizine and meprobamate both increase sedation. Use Caution/Monitor.

                  • metaproterenol

                    cyclizine increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • metaxalone

                    cyclizine and metaxalone both increase sedation. Use Caution/Monitor.

                  • methadone

                    cyclizine and methadone both increase sedation. Use Caution/Monitor.

                  • methamphetamine

                    cyclizine increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • methocarbamol

                    cyclizine and methocarbamol both increase sedation. Use Caution/Monitor.

                  • methscopolamine

                    cyclizine and methscopolamine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • methylenedioxymethamphetamine

                    cyclizine increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • midazolam

                    cyclizine and midazolam both increase sedation. Use Caution/Monitor.

                  • midodrine

                    cyclizine increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • mirtazapine

                    cyclizine and mirtazapine both increase sedation. Use Caution/Monitor.

                  • modafinil

                    cyclizine increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • morphine

                    cyclizine and morphine both increase sedation. Use Caution/Monitor.

                  • motherwort

                    cyclizine and motherwort both increase sedation. Use Caution/Monitor.

                  • moxonidine

                    cyclizine and moxonidine both increase sedation. Use Caution/Monitor.

                  • nabilone

                    cyclizine and nabilone both increase sedation. Use Caution/Monitor.

                  • nalbuphine

                    cyclizine and nalbuphine both increase sedation. Use Caution/Monitor.

                  • neostigmine

                    neostigmine increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • norepinephrine

                    cyclizine increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nortriptyline

                    cyclizine and nortriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and nortriptyline both increase sedation. Use Caution/Monitor.

                  • olanzapine

                    cyclizine and olanzapine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of olanzapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of olanzapine by pharmacodynamic antagonism. Use Caution/Monitor.

                    olanzapine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • onabotulinumtoxinA

                    onabotulinumtoxinA and cyclizine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • opium tincture

                    cyclizine and opium tincture both increase sedation. Use Caution/Monitor.

                  • orphenadrine

                    cyclizine and orphenadrine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and orphenadrine both increase sedation. Use Caution/Monitor.

                  • oxazepam

                    cyclizine and oxazepam both increase sedation. Use Caution/Monitor.

                  • oxybutynin

                    cyclizine and oxybutynin both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • oxybutynin topical

                    cyclizine and oxybutynin topical both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • oxybutynin transdermal

                    cyclizine and oxybutynin transdermal both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • oxycodone

                    cyclizine and oxycodone both increase sedation. Use Caution/Monitor.

                  • oxymorphone

                    cyclizine and oxymorphone both increase sedation. Use Caution/Monitor.

                  • paliperidone

                    cyclizine and paliperidone both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of paliperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of paliperidone by pharmacodynamic antagonism. Use Caution/Monitor.

                    paliperidone increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • pancuronium

                    cyclizine and pancuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • papaveretum

                    cyclizine and papaveretum both increase sedation. Use Caution/Monitor.

                  • papaverine

                    cyclizine and papaverine both increase sedation. Use Caution/Monitor.

                  • passion flower

                    passion flower increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • pentazocine

                    cyclizine and pentazocine both increase sedation. Use Caution/Monitor.

                  • pentobarbital

                    cyclizine and pentobarbital both increase sedation. Use Caution/Monitor.

                  • perphenazine

                    cyclizine and perphenazine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of perphenazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of perphenazine by pharmacodynamic antagonism. Use Caution/Monitor.

                    perphenazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • phendimetrazine

                    cyclizine increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenobarbital

                    cyclizine and phenobarbital both increase sedation. Use Caution/Monitor.

                  • phentermine

                    cyclizine increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenylephrine

                    cyclizine increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenylephrine PO

                    cyclizine increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                  • pholcodine

                    cyclizine and pholcodine both increase sedation. Use Caution/Monitor.

                  • physostigmine

                    physostigmine increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • pilocarpine

                    pilocarpine increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • pimozide

                    cyclizine and pimozide both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of pimozide by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of pimozide by pharmacodynamic antagonism. Use Caution/Monitor.

                    pimozide increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • pirbuterol

                    cyclizine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • pralidoxime

                    cyclizine and pralidoxime both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • primidone

                    cyclizine and primidone both increase sedation. Use Caution/Monitor.

                  • prochlorperazine

                    cyclizine and prochlorperazine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of prochlorperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of prochlorperazine by pharmacodynamic antagonism. Use Caution/Monitor.

                    prochlorperazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • promethazine

                    cyclizine and promethazine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of promethazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of promethazine by pharmacodynamic antagonism. Use Caution/Monitor.

                    promethazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • propantheline

                    cyclizine and propantheline both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • propofol

                    propofol and cyclizine both increase sedation. Use Caution/Monitor.

                  • propylhexedrine

                    cyclizine increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • protriptyline

                    cyclizine and protriptyline both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and protriptyline both increase sedation. Use Caution/Monitor.

                  • pyridostigmine

                    pyridostigmine increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • quazepam

                    cyclizine and quazepam both increase sedation. Use Caution/Monitor.

                  • quetiapine

                    cyclizine and quetiapine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of quetiapine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of quetiapine by pharmacodynamic antagonism. Use Caution/Monitor.

                    quetiapine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • ramelteon

                    cyclizine and ramelteon both increase sedation. Use Caution/Monitor.

                  • rapacuronium

                    cyclizine and rapacuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • risperidone

                    cyclizine and risperidone both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of risperidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of risperidone by pharmacodynamic antagonism. Use Caution/Monitor.

                    risperidone increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • rocuronium

                    cyclizine and rocuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • salmeterol

                    cyclizine increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • scopolamine

                    cyclizine and scopolamine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • scullcap

                    cyclizine and scullcap both increase sedation. Use Caution/Monitor.

                  • secobarbital

                    cyclizine and secobarbital both increase sedation. Use Caution/Monitor.

                  • sevoflurane

                    sevoflurane and cyclizine both increase sedation. Use Caution/Monitor.

                  • shepherd's purse

                    cyclizine and shepherd's purse both increase sedation. Use Caution/Monitor.

                  • solifenacin

                    cyclizine and solifenacin both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • succinylcholine

                    succinylcholine increases and cyclizine decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • sufentanil

                    cyclizine and sufentanil both increase sedation. Use Caution/Monitor.

                  • tapentadol

                    cyclizine and tapentadol both increase sedation. Use Caution/Monitor.

                  • temazepam

                    cyclizine and temazepam both increase sedation. Use Caution/Monitor.

                  • terbutaline

                    cyclizine increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • thioridazine

                    cyclizine and thioridazine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of thioridazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of thioridazine by pharmacodynamic antagonism. Use Caution/Monitor.

                    thioridazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • thiothixene

                    cyclizine and thiothixene both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of thiothixene by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of thiothixene by pharmacodynamic antagonism. Use Caution/Monitor.

                    thiothixene increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • tiotropium

                    cyclizine and tiotropium both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • tolterodine

                    cyclizine and tolterodine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • topiramate

                    cyclizine and topiramate both increase sedation. Modify Therapy/Monitor Closely.

                  • tramadol

                    cyclizine and tramadol both increase sedation. Use Caution/Monitor.

                  • trazodone

                    cyclizine and trazodone both increase sedation. Use Caution/Monitor.

                  • triazolam

                    cyclizine and triazolam both increase sedation. Use Caution/Monitor.

                  • triclofos

                    cyclizine and triclofos both increase sedation. Use Caution/Monitor.

                  • trifluoperazine

                    cyclizine and trifluoperazine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of trifluoperazine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of trifluoperazine by pharmacodynamic antagonism. Use Caution/Monitor.

                    trifluoperazine increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • trihexyphenidyl

                    cyclizine and trihexyphenidyl both decrease cholinergic effects/transmission. Use Caution/Monitor. Potential for additive anticholinergic effects.

                  • trimipramine

                    cyclizine and trimipramine both decrease cholinergic effects/transmission. Use Caution/Monitor.

                    cyclizine and trimipramine both increase sedation. Use Caution/Monitor.

                  • triprolidine

                    cyclizine and triprolidine both increase sedation. Use Caution/Monitor.

                  • trospium chloride

                    cyclizine and trospium chloride both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • valerian

                    valerian increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. May enhance CNS depression.

                  • vecuronium

                    cyclizine and vecuronium both decrease cholinergic effects/transmission. Use Caution/Monitor.

                  • xylometazoline

                    cyclizine increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • yohimbine

                    cyclizine increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ziconotide

                    cyclizine and ziconotide both increase sedation. Use Caution/Monitor.

                  • ziprasidone

                    cyclizine and ziprasidone both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of ziprasidone by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of ziprasidone by pharmacodynamic antagonism. Use Caution/Monitor.

                    ziprasidone increases effects of cyclizine by pharmacodynamic synergism. Use Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

                  • zotepine

                    cyclizine and zotepine both increase sedation. Use Caution/Monitor.

                    cyclizine decreases levels of zotepine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor.

                    cyclizine decreases levels of zotepine by pharmacodynamic antagonism. Use Caution/Monitor.

                  Minor (11)

                  • ashwagandha

                    ashwagandha increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                  • brimonidine

                    brimonidine increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

                  • desipramine

                    cyclizine and desipramine both decrease cholinergic effects/transmission. Minor/Significance Unknown.

                  • dimenhydrinate

                    dimenhydrinate increases toxicity of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. Additive anticholinergic effects.

                  • donepezil

                    donepezil decreases effects of cyclizine by pharmacodynamic antagonism. Minor/Significance Unknown.

                  • eucalyptus

                    cyclizine and eucalyptus both increase sedation. Minor/Significance Unknown.

                  • galantamine

                    galantamine decreases effects of cyclizine by pharmacodynamic antagonism. Minor/Significance Unknown.

                  • nettle

                    nettle increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. (High dose nettle; theoretical interaction) May enhance CNS depression.

                  • sage

                    cyclizine and sage both increase sedation. Minor/Significance Unknown.

                  • Siberian ginseng

                    Siberian ginseng increases effects of cyclizine by pharmacodynamic synergism. Minor/Significance Unknown. May enhance CNS depression.

                  • trazodone

                    cyclizine and trazodone both decrease cholinergic effects/transmission. Minor/Significance Unknown.

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                  Adverse Effects

                  >10%

                  Drowsiness

                  Xerostomia

                  1-10%

                  Headache

                  Dermatitis

                  Nausea

                  Urinary retention

                  Diplopia

                  Polyuria

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                  Warnings

                  Contraindications

                  Hypersensitivity

                  Do not use in patients with asthma, glaucoma, emphysema, chronic pulmonary disease, shortness of breath, difficulty in breathing or difficulty in urination due to enlargement of the prostate gland unless directed by a doctor

                  Cyclizine should not be used concurrently with sedatives, tranquilizers, or anticholinergic medications

                  Cautions

                  May have hypotensive effects, which may be confusing or dangerous in postoperative patients

                  May produce drowsiness; caution while driving or performing other tasks requiring alertness

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                  Pregnancy & Lactation

                  Pregnancy Category: B

                  Lactation: unknown

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Cyclizine is a piperazine derivative that has antiemetic, anticholinergic, and antihistaminic properties; reduces the sensitivity of the labyrinthine apparatus and has central actions on the chemoreceptor trigger zone

                  Pharmacokinetics

                  Onset: 30 to 60 minutes, depending on dose

                  Duration: 4 to 6 hr

                  Metabolism: Hepatic

                  Half-life elimination: 14 hr (cyclizine); 24hr (norcyclizine)

                  Excretion: Urine (<1% unchanged)

                  Vd: 17 L/kg

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                  Images

                  No images available for this drug.
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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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