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      News & Perspective Drugs & Diseases CME & Education Academy Video Decision Point
      Drugs & Diseases

      pirbuterol (Discontinued)

      Brand and Other Names:Maxair
      • Print

      Dosing & Uses

      AdultPediatric

      Dosage Forms & Strengths

      metered dose inhaler

      • 200mcg/actuation (14g canister; ~400 actuations)

      Asthma Maintenance Treatment

      1-2 actuations q4-6hr PRN; not to exceed 12 actuations/day

      CFC-propelled MDIs are being phased out; Maxair will not be manufactured, sold, or dispensed in the US after 12/31/13

      Dosage Forms & Strengths

      metered dose inhaler

      • 200mcg/actuation (14g canister; ~400 actuations)

      Asthma Maintenance Treatment

      <12 years: Safety and efficacy not established

      >12 years: As adults; 1-2 actuations q4-6hr PRN; not to exceed 12 actuations/day

      CFC-propelled MDIs are being phased out; Maxair will not be manufactured, sold, or dispensed in the US after 12/31/13

      Next:

      Interactions

      Interaction Checker

      and pirbuterol

      No Results

         activity indicator 
        No Interactions Found
        Interactions Found

        Contraindicated

          Serious - Use Alternative

            Significant - Monitor Closely

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                All Interactions Sort By:
                 activity indicator 

                Contraindicated (0)

                  Serious - Use Alternative (16)

                  • amitriptyline

                    amitriptyline, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • amoxapine

                    amoxapine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • clomipramine

                    clomipramine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • desipramine

                    desipramine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • doxepin

                    doxepin, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • imipramine

                    imipramine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • isocarboxazid

                    isocarboxazid increases effects of pirbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

                  • linezolid

                    linezolid increases effects of pirbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

                  • lofepramine

                    lofepramine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • maprotiline

                    maprotiline, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • nortriptyline

                    nortriptyline, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • phenelzine

                    phenelzine increases effects of pirbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

                  • protriptyline

                    protriptyline, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • tranylcypromine

                    tranylcypromine increases effects of pirbuterol by pharmacodynamic synergism. Contraindicated. Risk of acute hypertensive episode.

                  • trazodone

                    trazodone, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  • trimipramine

                    trimipramine, pirbuterol. Other (see comment). Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.

                  Monitor Closely (231)

                  • acebutolol

                    acebutolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    acebutolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • aceclofenac

                    aceclofenac increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • acemetacin

                    acemetacin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • albuterol

                    albuterol and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    albuterol and pirbuterol both decrease sedation. Use Caution/Monitor.

                    albuterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • alfentanil

                    alfentanil increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • alprazolam

                    alprazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • amiloride

                    amiloride increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                  • amitriptyline

                    amitriptyline increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • amobarbital

                    amobarbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • amoxapine

                    amoxapine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • arformoterol

                    arformoterol and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    arformoterol and pirbuterol both decrease sedation. Use Caution/Monitor.

                    arformoterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • aripiprazole

                    aripiprazole increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • armodafinil

                    pirbuterol and armodafinil both decrease sedation. Use Caution/Monitor.

                  • aspirin

                    aspirin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • aspirin rectal

                    aspirin rectal increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                  • aspirin/citric acid/sodium bicarbonate

                    aspirin/citric acid/sodium bicarbonate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • atenolol

                    atenolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    atenolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • atomoxetine

                    pirbuterol, atomoxetine. Other (see comment). Use Caution/Monitor. Comment: Exercise caution if beta-agonists and atomoxetine are coadministered. Interaction may be less likely with inhaled beta-agonists versus those given systemically. .

                  • azelastine

                    azelastine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • belladonna and opium

                    belladonna and opium increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • bendroflumethiazide

                    pirbuterol and bendroflumethiazide both decrease serum potassium. Use Caution/Monitor.

                  • benperidol

                    benperidol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • benzphetamine

                    pirbuterol and benzphetamine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and benzphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • betaxolol

                    betaxolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    betaxolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • bisoprolol

                    bisoprolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    bisoprolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • brompheniramine

                    brompheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • bumetanide

                    pirbuterol and bumetanide both decrease serum potassium. Use Caution/Monitor.

                  • buprenorphine buccal

                    buprenorphine buccal increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • butabarbital

                    butabarbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • butalbital

                    butalbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • butorphanol

                    butorphanol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • caffeine

                    pirbuterol and caffeine both decrease sedation. Use Caution/Monitor.

                  • carbenoxolone

                    pirbuterol and carbenoxolone both decrease serum potassium. Use Caution/Monitor.

                  • carbinoxamine

                    carbinoxamine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • carvedilol

                    carvedilol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    carvedilol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • celecoxib

                    celecoxib increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • celiprolol

                    celiprolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    celiprolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • chloral hydrate

                    chloral hydrate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • chlordiazepoxide

                    chlordiazepoxide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • chlorothiazide

                    pirbuterol and chlorothiazide both decrease serum potassium. Use Caution/Monitor.

                  • chlorpheniramine

                    chlorpheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • chlorpromazine

                    chlorpromazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • chlorthalidone

                    pirbuterol and chlorthalidone both decrease serum potassium. Use Caution/Monitor.

                  • choline magnesium trisalicylate

                    choline magnesium trisalicylate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                  • cinnarizine

                    cinnarizine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • clemastine

                    clemastine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • clomipramine

                    clomipramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • clonazepam

                    clonazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • clorazepate

                    clorazepate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • clozapine

                    clozapine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • codeine

                    codeine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • cyclizine

                    cyclizine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • cyclopenthiazide

                    pirbuterol and cyclopenthiazide both decrease serum potassium. Use Caution/Monitor.

                  • cyproheptadine

                    cyproheptadine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • deflazacort

                    pirbuterol and deflazacort both decrease serum potassium. Use Caution/Monitor.

                  • desipramine

                    desipramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dexchlorpheniramine

                    dexchlorpheniramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dexfenfluramine

                    pirbuterol and dexfenfluramine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and dexfenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • dexmedetomidine

                    dexmedetomidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dexmethylphenidate

                    pirbuterol and dexmethylphenidate both decrease sedation. Use Caution/Monitor.

                    pirbuterol and dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • dextroamphetamine

                    pirbuterol and dextroamphetamine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and dextroamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • dextromoramide

                    dextromoramide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • diamorphine

                    diamorphine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • diclofenac

                    diclofenac increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • diethylpropion

                    pirbuterol and diethylpropion both decrease sedation. Use Caution/Monitor.

                    pirbuterol and diethylpropion both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • difenoxin hcl

                    difenoxin hcl increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • diflunisal

                    diflunisal increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • digoxin

                    digoxin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dimenhydrinate

                    dimenhydrinate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • diphenhydramine

                    diphenhydramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • diphenoxylate hcl

                    diphenoxylate hcl increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dipipanone

                    dipipanone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • dobutamine

                    dobutamine and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    dobutamine and pirbuterol both decrease sedation. Use Caution/Monitor.

                    dobutamine and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • dopamine

                    pirbuterol and dopamine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • dopexamine

                    dopexamine and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    dopexamine and pirbuterol both decrease sedation. Use Caution/Monitor.

                    dopexamine and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                    dopexamine, pirbuterol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor.

                  • doxepin

                    doxepin increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • droperidol

                    droperidol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • drospirenone

                    drospirenone increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                  • ephedrine

                    ephedrine and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    ephedrine and pirbuterol both decrease sedation. Use Caution/Monitor.

                    ephedrine and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • epinephrine

                    epinephrine and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    epinephrine and pirbuterol both decrease sedation. Use Caution/Monitor.

                    epinephrine and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • epinephrine racemic

                    pirbuterol and epinephrine racemic both decrease serum potassium. Use Caution/Monitor.

                    pirbuterol and epinephrine racemic both decrease sedation. Use Caution/Monitor.

                    pirbuterol and epinephrine racemic both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • esmolol

                    esmolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    esmolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • estazolam

                    estazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ethacrynic acid

                    pirbuterol and ethacrynic acid both decrease serum potassium. Use Caution/Monitor.

                  • ethanol

                    ethanol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • etodolac

                    etodolac increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • fenfluramine

                    pirbuterol and fenfluramine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and fenfluramine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • fenoprofen

                    fenoprofen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • fluoxetine

                    fluoxetine and pirbuterol both increase QTc interval. Modify Therapy/Monitor Closely. Fluoxetine prolongs the QT interval; the prescribing information for fluoxetine recommends avoiding concurrent use of other drugs that may prolong the QT interval; risk may be increased with higher doses and/or when associated with hypokalemia; drugs that prolong the QTc interval may potentiate the effects of beta2 agonists on the cardiovascular system

                  • fluphenazine

                    fluphenazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • flurazepam

                    flurazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • flurbiprofen

                    flurbiprofen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • formoterol

                    formoterol and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    formoterol and pirbuterol both decrease sedation. Use Caution/Monitor.

                    formoterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • furosemide

                    pirbuterol and furosemide both decrease serum potassium. Use Caution/Monitor.

                  • gentamicin

                    pirbuterol and gentamicin both decrease serum potassium. Use Caution/Monitor.

                  • green tea

                    green tea increases effects of pirbuterol by pharmacodynamic synergism. Use Caution/Monitor. Due to caffeine content. Combination may increase CNS stimulatory effects due to caffeine in green tea.

                  • haloperidol

                    haloperidol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • hydrochlorothiazide

                    pirbuterol and hydrochlorothiazide both decrease serum potassium. Use Caution/Monitor.

                  • hydromorphone

                    hydromorphone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • hydroxyzine

                    hydroxyzine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ibuprofen

                    ibuprofen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ibuprofen IV

                    ibuprofen IV increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • iloperidone

                    iloperidone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • imipramine

                    imipramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • indapamide

                    pirbuterol and indapamide both decrease serum potassium. Use Caution/Monitor.

                  • indomethacin

                    indomethacin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • isoproterenol

                    isoproterenol and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    isoproterenol and pirbuterol both decrease sedation. Use Caution/Monitor.

                    isoproterenol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • ketoprofen

                    ketoprofen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ketorolac

                    ketorolac increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ketorolac intranasal

                    ketorolac intranasal increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

                  • ketotifen, ophthalmic

                    ketotifen, ophthalmic increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • labetalol

                    labetalol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    labetalol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • levalbuterol

                    levalbuterol and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    levalbuterol and pirbuterol both decrease sedation. Use Caution/Monitor.

                    levalbuterol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • levorphanol

                    levorphanol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lisdexamfetamine

                    pirbuterol and lisdexamfetamine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and lisdexamfetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • lofepramine

                    lofepramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lofexidine

                    lofexidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • loprazolam

                    loprazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lorazepam

                    lorazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lormetazepam

                    lormetazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • lornoxicam

                    lornoxicam increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • loxapine

                    loxapine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • loxapine inhaled

                    loxapine inhaled increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • maprotiline

                    maprotiline increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • marijuana

                    marijuana increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • meclofenamate

                    meclofenamate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • mefenamic acid

                    mefenamic acid increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • melatonin

                    melatonin increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • meloxicam

                    meloxicam increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • meperidine

                    meperidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • meprobamate

                    meprobamate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • metaproterenol

                    metaproterenol and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    metaproterenol and pirbuterol both decrease sedation. Use Caution/Monitor.

                    metaproterenol and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • methadone

                    methadone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • methamphetamine

                    pirbuterol and methamphetamine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and methamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • methyclothiazide

                    pirbuterol and methyclothiazide both decrease serum potassium. Use Caution/Monitor.

                  • methylenedioxymethamphetamine

                    pirbuterol and methylenedioxymethamphetamine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and methylenedioxymethamphetamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • methylphenidate

                    pirbuterol and methylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • metolazone

                    pirbuterol and metolazone both decrease serum potassium. Use Caution/Monitor.

                  • metoprolol

                    metoprolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    metoprolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • midazolam

                    midazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • midodrine

                    pirbuterol and midodrine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and midodrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • mirtazapine

                    mirtazapine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • modafinil

                    pirbuterol and modafinil both decrease sedation. Use Caution/Monitor.

                  • morphine

                    morphine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • motherwort

                    motherwort increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • moxonidine

                    moxonidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nabilone

                    nabilone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nabumetone

                    nabumetone increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nadolol

                    nadolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    nadolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • nalbuphine

                    nalbuphine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • naproxen

                    naproxen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • nebivolol

                    nebivolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    nebivolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • norepinephrine

                    norepinephrine and pirbuterol both decrease serum potassium. Use Caution/Monitor.

                    norepinephrine and pirbuterol both decrease sedation. Use Caution/Monitor.

                    norepinephrine and pirbuterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • nortriptyline

                    nortriptyline increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • olanzapine

                    olanzapine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • olodaterol inhaled

                    pirbuterol and olodaterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effects

                  • opium tincture

                    opium tincture increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • oxaprozin

                    oxaprozin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • oxazepam

                    oxazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • oxycodone

                    oxycodone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • oxymorphone

                    oxymorphone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • paliperidone

                    paliperidone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • papaveretum

                    papaveretum increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • parecoxib

                    parecoxib increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • penbutolol

                    penbutolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    penbutolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • pentazocine

                    pentazocine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • pentobarbital

                    pentobarbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • perphenazine

                    perphenazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phendimetrazine

                    pirbuterol and phendimetrazine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and phendimetrazine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • phenobarbital

                    phenobarbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • phenoxybenzamine

                    phenoxybenzamine, pirbuterol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Hypotension, tachycardia.

                  • phentermine

                    pirbuterol and phentermine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and phentermine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • phenylephrine

                    pirbuterol and phenylephrine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and phenylephrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • phenylephrine PO

                    pirbuterol and phenylephrine PO both decrease sedation. Use Caution/Monitor.

                    pirbuterol and phenylephrine PO both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • pholcodine

                    pholcodine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • pimozide

                    pimozide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • pindolol

                    pindolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    pindolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • piroxicam

                    piroxicam increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • potassium acid phosphate

                    potassium acid phosphate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                  • potassium chloride

                    potassium chloride increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                  • potassium citrate

                    potassium citrate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                  • primidone

                    primidone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • procarbazine

                    procarbazine increases effects of pirbuterol by pharmacodynamic synergism. Use Caution/Monitor.

                  • prochlorperazine

                    prochlorperazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • promethazine

                    promethazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • propranolol

                    propranolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    propranolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • propylhexedrine

                    pirbuterol and propylhexedrine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and propylhexedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • protriptyline

                    protriptyline increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • pseudoephedrine

                    pirbuterol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • quazepam

                    quazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • quetiapine

                    quetiapine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • risperidone

                    risperidone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • sacubitril/valsartan

                    sacubitril/valsartan increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • salicylates (non-asa)

                    salicylates (non-asa) increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • salmeterol

                    pirbuterol and salmeterol both decrease serum potassium. Use Caution/Monitor.

                    pirbuterol and salmeterol both decrease sedation. Use Caution/Monitor.

                    pirbuterol and salmeterol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • salsalate

                    salsalate increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • scullcap

                    scullcap increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • secobarbital

                    secobarbital increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • serdexmethylphenidate/dexmethylphenidate

                    pirbuterol and serdexmethylphenidate/dexmethylphenidate both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • shepherd's purse

                    shepherd's purse increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol

                    pirbuterol and sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol both decrease serum potassium. Modify Therapy/Monitor Closely.

                  • solriamfetol

                    pirbuterol and solriamfetol both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • sotalol

                    sotalol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    sotalol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • spironolactone

                    spironolactone increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                  • succinylcholine

                    succinylcholine increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • sufentanil

                    sufentanil increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • sulfasalazine

                    sulfasalazine increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • sulindac

                    sulindac increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • tapentadol

                    tapentadol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • temazepam

                    temazepam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • terbutaline

                    pirbuterol and terbutaline both decrease serum potassium. Use Caution/Monitor.

                    pirbuterol and terbutaline both decrease sedation. Use Caution/Monitor.

                    pirbuterol and terbutaline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • thioridazine

                    thioridazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • thiothixene

                    thiothixene increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • timolol

                    timolol increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                    timolol decreases effects of pirbuterol by pharmacodynamic antagonism. Use Caution/Monitor.

                  • tolfenamic acid

                    tolfenamic acid increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • tolmetin

                    tolmetin increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • tolvaptan

                    tolvaptan increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • topiramate

                    topiramate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                  • torsemide

                    pirbuterol and torsemide both decrease serum potassium. Use Caution/Monitor.

                  • tramadol

                    tramadol increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • trazodone

                    trazodone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • triamterene

                    triamterene increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely.

                  • triazolam

                    triazolam increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • triclofos

                    triclofos increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • trifluoperazine

                    trifluoperazine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • trimipramine

                    trimipramine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • triprolidine

                    triprolidine increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • xylometazoline

                    pirbuterol and xylometazoline both decrease sedation. Use Caution/Monitor.

                    pirbuterol and xylometazoline both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • yohimbine

                    pirbuterol and yohimbine both decrease sedation. Use Caution/Monitor.

                    pirbuterol and yohimbine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor.

                  • ziconotide

                    ziconotide increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  • ziprasidone

                    ziprasidone increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

                  Minor (15)

                  • bendroflumethiazide

                    pirbuterol, bendroflumethiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • bumetanide

                    pirbuterol, bumetanide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • chlorothiazide

                    pirbuterol, chlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • chlorthalidone

                    pirbuterol, chlorthalidone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • cyclopenthiazide

                    pirbuterol, cyclopenthiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • ethacrynic acid

                    pirbuterol, ethacrynic acid. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • eucalyptus

                    eucalyptus increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                  • furosemide

                    pirbuterol, furosemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • hydrochlorothiazide

                    pirbuterol, hydrochlorothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • indapamide

                    pirbuterol, indapamide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • methyclothiazide

                    pirbuterol, methyclothiazide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • metolazone

                    pirbuterol, metolazone. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

                  • noni juice

                    noni juice increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                  • sage

                    sage increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Minor/Significance Unknown.

                  • torsemide

                    pirbuterol, torsemide. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Hypokalemia.

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                  Adverse Effects

                  Frequency Not Defined

                  Nervousness

                  Restlessness

                  Serum glucose increased

                  Serum potassium decreased

                  Trembling

                  Palpitations

                  Tachycardia

                  CoughHeadache

                  Dizziness

                  Lightheadedness

                  Taste changes

                  Vomiting

                  Nausea

                  Paradoxical bronchospasm

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                  Warnings

                  Contraindications

                  Hypersensitivity

                  Cautions

                  Risk of hypokalemia, usually transient

                  Metered-dose inhalers that contain chlorofluorocarbons (CFCs) are currently being phased out in the United States; alternate inhalers without CFCs are available

                  Use caution in cardiovascular disease, glaucoma, hyperthyroidism, hypokalemia, and seizure disorders

                  May increase serum glucose; use caution in diabetes mellitus

                  Fatal outcomes reported with excessive use of therapy

                  Not for use in chronic asthma therapy unless anti-inflammatory agent use concomitantly

                  Paradoxical bronchospasm may occur with therapy

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                  Pregnancy & Lactation

                  Pregnancy Category: C

                  Lactation: Not known if excreted in breast milk; not recommended

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Beta-2 receptor agonist with some beta-1 activity

                  Pharmacokinetics

                  Half-Life: 2 hr

                  Onset: <5 min; 0.5-1 hr (peak effect)

                  Duration: 5 hr

                  Metabolism: Hepatic

                  Excretion: Urine (10%)

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                  Images

                  No images available for this drug.
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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
                  Previous
                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
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