acetaminophen IV/ibuprofen IV (Pending FDA Approval)

Brand and Other Names:Maxigesic
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Dosing & Uses

Postoperative Pain

Pending FDA approval for postoperative pain in adults aged ≥18 years

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Pharmacology

Mechanism of Action

Acetaminophen: Nonopioid analgesic that activates the descending serotonergic inhibitory pathways in the CNS

Ibuprofen: Nonsteroidal anti-inflammatory with analgesic, antipyretic, and anti-inflammation properties; acts by reversibly inhibiting cyclooxygenase-1 and 2 (COX-1 and COX-2) enzymes resulting in decreased prostaglandin precursor formation

Fixed-dose combination is an effective alternative to opioid-based analgesics and is thought to be synergistic at managing acute and chronic pain

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.