Taurine (Herb/Suppl)

Brand and Other Names:mega taurine
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Suggested Dosing

Congestive Heart Failure

2-6 g/day PO div BID-TID

Acute Hepatitis

4 g PO TID x 6 weeks

Treatment of Steatorrhea in Children with Cystic Fibrosis

30 mg/kg day x 4 months in addition to pancreatic enzyme supplementation

Cystathionine Beta-Synthase Deficient Homocystinuria (Orphan)

Indicated for treatment of cystathionine beta-synthase deficient homocystinuria

Orphan indication sponsor

  • Johan L. Van Hove, MD, PhD; Department of Pediatrics/University of Colorado DE; 13121 E. 17th Ave; PO Box 6508; Aurora, CO 80045
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Suggested Uses

CHF, hypertension, hypercholesterolemia, cystic fibrosis, antiatherogenic effects

Other uses include seizure disorders (epilepsy), autism, ADHD, retinal degeneration, diabetes, alcoholism, improve mental performance & antioxidant.

Efficacy

In human clinical studies taurine lowered blood pressure

CHF: Seems to improve left ventricular function in patients with New York Heart Association functional class II to IV

Acute Hepatitis: Might improve liver function

In animal studies taurine lowered lipid levels, but human studies are contradictory

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Interactions

Interaction Checker

and Taurine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (35)

                  • aldesleukin

                    aldesleukin decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • bicalutamide

                    bicalutamide decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • capecitabine

                    capecitabine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • cladribine

                    cladribine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • cytarabine

                    cytarabine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • decitabine

                    decitabine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • docetaxel

                    docetaxel decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • floxuridine

                    floxuridine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • fludarabine

                    fludarabine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • fluorouracil

                    fluorouracil decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • flutamide

                    flutamide decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • fulvestrant

                    fulvestrant decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • gemcitabine

                    gemcitabine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • goserelin

                    goserelin decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • leuprolide

                    leuprolide decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • medroxyprogesterone

                    medroxyprogesterone decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • megestrol

                    megestrol decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • mercaptopurine

                    mercaptopurine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • nelarabine

                    nelarabine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • nilutamide

                    nilutamide decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • oxaliplatin

                    oxaliplatin decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • paclitaxel

                    paclitaxel decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • paclitaxel protein bound

                    paclitaxel protein bound decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • pegaspargase

                    pegaspargase decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown. Taurine was found to reduce platelet aggregation and may increase the risk of bleeding.

                  • pentostatin

                    pentostatin decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • pralatrexate

                    pralatrexate decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • tamoxifen

                    tamoxifen decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • thioguanine

                    thioguanine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • toremifene

                    toremifene decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • treosulfan

                    treosulfan decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • triptorelin

                    triptorelin decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • vinblastine

                    vinblastine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • vincristine

                    vincristine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • vincristine liposomal

                    vincristine liposomal decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

                  • vinorelbine

                    vinorelbine decreases levels of taurine by unspecified interaction mechanism. Minor/Significance Unknown.

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                  Adverse Effects

                  None reported

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                  Warnings

                  Contraindications

                  Hypersensitivity

                  Cautions

                  Pregnancy, lactation

                  Monitor pts with CHF

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                  Pregnancy & Lactation

                  Pregnancy Category: avoid use

                  Lactation: avoid use

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Metabolism: liver

                  Excretion: feces & urine

                  Mechanism of Action

                  Antioxidant, putative hypocholesterolemic, hypotensive, antiatherogenic & detoxifying activities

                  May also have steatorrhea-reducing activity in pts with cystic fibrosis & putative antidiabetic, inotropic & antiseizure activities

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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.