meloxicam/rizatriptan (Pending FDA Approval)

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Dosing & Uses

Migraine Headache

Pending FDA approval for acute treatment of migraine

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Pharmacology

Mechanism of Action

Meloxicam: Inhibits synthesis of prostaglandins in body tissues by preferentially inhibiting cyclo-oxygenase (COX)-2

Rizatriptan: Serotonin 5-HT1B/1D agonist; causes vasoconstriction and reduces inflammation associated with antidromic neuronal transmission linked to relief of migraine

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.