Dosing & Uses
Dosage Forms & Strengths
tablet: Schedule IV
- 200mg
- 400mg
Anxiety
1200-1600 mg/day PO divided q6-8hr; not to exceed 2.4 g/day
Preoperative Sedation
400 mg PO before the procedure
Renal Impairment
CrCl 10-50 mL/min: Change frequency of administration to every 9-12hr
CrCl <10 mL/min: Change frequency of administration to 12-18hr
Hepatic Impairment
Use caution
Dosage Forms & Strengths
tablet: Schedule IV
- 200mg
- 400mg
Anxiety
<6 years old: Not recommended
6-12 years old: 100-200 mg PO q8-12hr
>12 years old: 1200-1600 mg/day PO divided q8-12hr; not to exceed 2.4 g/day
Preoperative Sedation
200 mg PO prior to procedure
Not drug of choice in elderly because of potential physical and psychological dependence
Use lowest effective dose to avoid oversedation
Anxiety
Lower initial dose; adjust more gradually; 200 mg PO q8-12hr
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (7)
- benzhydrocodone/acetaminophen
benzhydrocodone/acetaminophen, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- calcium/magnesium/potassium/sodium oxybates
meprobamate, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- hydrocodone
hydrocodone, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- metoclopramide intranasal
meprobamate, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
- olopatadine intranasal
meprobamate and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- sodium oxybate
meprobamate, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- sufentanil SL
sufentanil SL, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
Monitor Closely (186)
- acrivastine
acrivastine and meprobamate both increase sedation. Use Caution/Monitor.
- albuterol
meprobamate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
alfentanil and meprobamate both increase sedation. Use Caution/Monitor.
- alprazolam
alprazolam and meprobamate both increase sedation. Use Caution/Monitor.
- amitriptyline
amitriptyline and meprobamate both increase sedation. Use Caution/Monitor.
- amobarbital
amobarbital and meprobamate both increase sedation. Use Caution/Monitor.
- amoxapine
amoxapine and meprobamate both increase sedation. Use Caution/Monitor.
- apomorphine
apomorphine and meprobamate both increase sedation. Use Caution/Monitor.
- arformoterol
meprobamate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aripiprazole
aripiprazole and meprobamate both increase sedation. Use Caution/Monitor.
- armodafinil
meprobamate increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- asenapine
asenapine and meprobamate both increase sedation. Use Caution/Monitor.
- asenapine transdermal
asenapine transdermal and meprobamate both increase sedation. Use Caution/Monitor.
- avapritinib
avapritinib and meprobamate both increase sedation. Use Caution/Monitor.
- azelastine
azelastine and meprobamate both increase sedation. Use Caution/Monitor.
- baclofen
baclofen and meprobamate both increase sedation. Use Caution/Monitor.
- belladonna and opium
belladonna and opium and meprobamate both increase sedation. Use Caution/Monitor.
- benperidol
benperidol and meprobamate both increase sedation. Use Caution/Monitor.
- benzhydrocodone/acetaminophen
benzhydrocodone/acetaminophen and meprobamate both increase sedation. Use Caution/Monitor.
- benzphetamine
meprobamate increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brexanolone
brexanolone, meprobamate. Either increases toxicity of the other by sedation. Use Caution/Monitor.
- brexpiprazole
brexpiprazole and meprobamate both increase sedation. Use Caution/Monitor.
- brimonidine
brimonidine and meprobamate both increase sedation. Use Caution/Monitor.
- brivaracetam
brivaracetam and meprobamate both increase sedation. Use Caution/Monitor.
- brompheniramine
brompheniramine and meprobamate both increase sedation. Use Caution/Monitor.
- buprenorphine
buprenorphine and meprobamate both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
buprenorphine buccal and meprobamate both increase sedation. Use Caution/Monitor.
- buprenorphine subdermal implant
buprenorphine subdermal implant and meprobamate both increase sedation. Use Caution/Monitor.
- buprenorphine, long-acting injection
meprobamate increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.
- butabarbital
butabarbital and meprobamate both increase sedation. Use Caution/Monitor.
- butalbital
butalbital and meprobamate both increase sedation. Use Caution/Monitor.
- butorphanol
butorphanol and meprobamate both increase sedation. Use Caution/Monitor.
- caffeine
meprobamate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and meprobamate both increase sedation. Use Caution/Monitor.
- carisoprodol
carisoprodol and meprobamate both increase sedation. Use Caution/Monitor.
- chloral hydrate
chloral hydrate and meprobamate both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
chlordiazepoxide and meprobamate both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.
- chlorpromazine
chlorpromazine and meprobamate both increase sedation. Use Caution/Monitor.
- chlorzoxazone
chlorzoxazone and meprobamate both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and meprobamate both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and meprobamate both increase sedation. Use Caution/Monitor.
- clobazam
meprobamate, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).
- clomipramine
clomipramine and meprobamate both increase sedation. Use Caution/Monitor.
- clonazepam
clonazepam and meprobamate both increase sedation. Use Caution/Monitor.
- clorazepate
clorazepate and meprobamate both increase sedation. Use Caution/Monitor.
- clozapine
clozapine and meprobamate both increase sedation. Use Caution/Monitor.
- codeine
codeine and meprobamate both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and meprobamate both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
cyclobenzaprine and meprobamate both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and meprobamate both increase sedation. Use Caution/Monitor.
- dantrolene
dantrolene and meprobamate both increase sedation. Use Caution/Monitor.
- daridorexant
meprobamate and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- desipramine
desipramine and meprobamate both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.
- dexfenfluramine
meprobamate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
dexmedetomidine and meprobamate both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
meprobamate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
meprobamate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
dextromoramide and meprobamate both increase sedation. Use Caution/Monitor.
- diamorphine
diamorphine and meprobamate both increase sedation. Use Caution/Monitor.
- diazepam
diazepam and meprobamate both increase sedation. Use Caution/Monitor.
- diethylpropion
meprobamate increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difelikefalin
difelikefalin and meprobamate both increase sedation. Use Caution/Monitor.
- difenoxin hcl
difenoxin hcl and meprobamate both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dimenhydrinate and meprobamate both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and meprobamate both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
diphenoxylate hcl and meprobamate both increase sedation. Use Caution/Monitor.
- dipipanone
dipipanone and meprobamate both increase sedation. Use Caution/Monitor.
- dobutamine
meprobamate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopamine
meprobamate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
meprobamate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- doxepin
doxepin and meprobamate both increase sedation. Use Caution/Monitor.
- doxylamine
doxylamine and meprobamate both increase sedation. Use Caution/Monitor.
- droperidol
droperidol and meprobamate both increase sedation. Use Caution/Monitor.
- ephedrine
meprobamate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
meprobamate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
meprobamate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- estazolam
estazolam and meprobamate both increase sedation. Use Caution/Monitor.
- ethanol
ethanol and meprobamate both increase sedation. Use Caution/Monitor.
meprobamate, ethanol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive CNS depression. - etomidate
etomidate and meprobamate both increase sedation. Use Caution/Monitor.
- fenfluramine
meprobamate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fluphenazine
fluphenazine and meprobamate both increase sedation. Use Caution/Monitor.
- flurazepam
flurazepam and meprobamate both increase sedation. Use Caution/Monitor.
- formoterol
meprobamate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- gabapentin
gabapentin, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- gabapentin enacarbil
gabapentin enacarbil, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- ganaxolone
meprobamate and ganaxolone both increase sedation. Use Caution/Monitor.
- haloperidol
haloperidol and meprobamate both increase sedation. Use Caution/Monitor.
- hydromorphone
hydromorphone and meprobamate both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and meprobamate both increase sedation. Use Caution/Monitor.
- iloperidone
iloperidone and meprobamate both increase sedation. Use Caution/Monitor.
- imipramine
imipramine and meprobamate both increase sedation. Use Caution/Monitor.
- isoproterenol
meprobamate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ketamine
ketamine and meprobamate both increase sedation. Use Caution/Monitor.
- ketotifen, ophthalmic
ketotifen, ophthalmic and meprobamate both increase sedation. Use Caution/Monitor.
- lasmiditan
lasmiditan, meprobamate. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
- lemborexant
lemborexant, meprobamate. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
- levalbuterol
meprobamate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levorphanol
levorphanol and meprobamate both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
meprobamate increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
lofepramine and meprobamate both increase sedation. Use Caution/Monitor.
- lofexidine
lofexidine and meprobamate both increase sedation. Use Caution/Monitor.
- loprazolam
loprazolam and meprobamate both increase sedation. Use Caution/Monitor.
- lorazepam
lorazepam and meprobamate both increase sedation. Use Caution/Monitor.
- lormetazepam
lormetazepam and meprobamate both increase sedation. Use Caution/Monitor.
- loxapine
loxapine and meprobamate both increase sedation. Use Caution/Monitor.
- loxapine inhaled
loxapine inhaled and meprobamate both increase sedation. Use Caution/Monitor.
- lurasidone
lurasidone, meprobamate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
- maprotiline
maprotiline and meprobamate both increase sedation. Use Caution/Monitor.
- marijuana
marijuana and meprobamate both increase sedation. Use Caution/Monitor.
- melatonin
melatonin and meprobamate both increase sedation. Use Caution/Monitor.
- meperidine
meperidine and meprobamate both increase sedation. Use Caution/Monitor.
- metaproterenol
meprobamate increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
metaxalone and meprobamate both increase sedation. Use Caution/Monitor.
- methadone
methadone and meprobamate both increase sedation. Use Caution/Monitor.
- methamphetamine
meprobamate increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
methocarbamol and meprobamate both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
meprobamate increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
midazolam and meprobamate both increase sedation. Use Caution/Monitor.
- midodrine
meprobamate increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
meprobamate and mirtazapine both increase sedation. Use Caution/Monitor.
- modafinil
meprobamate increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
morphine and meprobamate both increase sedation. Use Caution/Monitor.
- motherwort
meprobamate and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
meprobamate and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
meprobamate and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
nalbuphine and meprobamate both increase sedation. Use Caution/Monitor.
- norepinephrine
meprobamate increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
nortriptyline and meprobamate both increase sedation. Use Caution/Monitor.
- olanzapine
olanzapine and meprobamate both increase sedation. Use Caution/Monitor.
- oliceridine
oliceridine, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- opium tincture
opium tincture and meprobamate both increase sedation. Use Caution/Monitor.
- orphenadrine
orphenadrine and meprobamate both increase sedation. Use Caution/Monitor.
- oxazepam
oxazepam and meprobamate both increase sedation. Use Caution/Monitor.
- oxycodone
oxycodone and meprobamate both increase sedation. Use Caution/Monitor.
- oxymorphone
oxymorphone and meprobamate both increase sedation. Use Caution/Monitor.
- paliperidone
paliperidone and meprobamate both increase sedation. Use Caution/Monitor.
- papaveretum
papaveretum and meprobamate both increase sedation. Use Caution/Monitor.
- papaverine
meprobamate and papaverine both increase sedation. Use Caution/Monitor.
- pentazocine
pentazocine and meprobamate both increase sedation. Use Caution/Monitor.
- pentobarbital
pentobarbital and meprobamate both increase sedation. Use Caution/Monitor.
- perphenazine
perphenazine and meprobamate both increase sedation. Use Caution/Monitor.
- phendimetrazine
meprobamate increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenobarbital
phenobarbital and meprobamate both increase sedation. Use Caution/Monitor.
- phentermine
meprobamate increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
meprobamate increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
meprobamate increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
meprobamate and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
pimozide and meprobamate both increase sedation. Use Caution/Monitor.
- pirbuterol
meprobamate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- pregabalin
pregabalin, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.
- primidone
primidone and meprobamate both increase sedation. Use Caution/Monitor.
- prochlorperazine
prochlorperazine and meprobamate both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and meprobamate both increase sedation. Use Caution/Monitor.
- propofol
propofol and meprobamate both increase sedation. Use Caution/Monitor.
- propylhexedrine
meprobamate increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
protriptyline and meprobamate both increase sedation. Use Caution/Monitor.
- quazepam
quazepam and meprobamate both increase sedation. Use Caution/Monitor.
- quetiapine
quetiapine and meprobamate both increase sedation. Use Caution/Monitor.
- ramelteon
meprobamate and ramelteon both increase sedation. Use Caution/Monitor.
- risperidone
risperidone and meprobamate both increase sedation. Use Caution/Monitor.
- salmeterol
meprobamate increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
meprobamate and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
secobarbital and meprobamate both increase sedation. Use Caution/Monitor.
- sevoflurane
sevoflurane and meprobamate both increase sedation. Use Caution/Monitor.
- shepherd's purse
meprobamate and shepherd's purse both increase sedation. Use Caution/Monitor.
- stiripentol
stiripentol, meprobamate. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
- sufentanil
sufentanil and meprobamate both increase sedation. Use Caution/Monitor.
- tapentadol
tapentadol and meprobamate both increase sedation. Use Caution/Monitor.
- temazepam
temazepam and meprobamate both increase sedation. Use Caution/Monitor.
- terbutaline
meprobamate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
thioridazine and meprobamate both increase sedation. Use Caution/Monitor.
- thiothixene
thiothixene and meprobamate both increase sedation. Use Caution/Monitor.
- topiramate
meprobamate and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
tramadol and meprobamate both increase sedation. Use Caution/Monitor.
- trazodone
trazodone and meprobamate both increase sedation. Use Caution/Monitor.
- triazolam
triazolam and meprobamate both increase sedation. Use Caution/Monitor.
- triclofos
triclofos and meprobamate both increase sedation. Use Caution/Monitor.
- trifluoperazine
trifluoperazine and meprobamate both increase sedation. Use Caution/Monitor.
- trimipramine
trimipramine and meprobamate both increase sedation. Use Caution/Monitor.
- triprolidine
triprolidine and meprobamate both increase sedation. Use Caution/Monitor.
- xylometazoline
meprobamate increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
meprobamate increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
meprobamate and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
ziprasidone and meprobamate both increase sedation. Use Caution/Monitor.
Minor (3)
- brimonidine
brimonidine increases effects of meprobamate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.
- eucalyptus
eucalyptus and meprobamate both increase sedation. Minor/Significance Unknown.
- sage
meprobamate and sage both increase sedation. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Common
- Abnormal ECG, palpitations, tachyarrhythmia
- Asthenia, ataxia, dizziness, EEG abnormality, euphoria, fast, excitement, paradoxical, headache, paresthesia, slurred speech, somnolence, vertigo
- Hives, maculopapular eruption, erythematous
- Diarrhea, nausea, vomiting
- Disorder of accommodation (ocular)
Serious
- Cardiac dysrhythmia, hypotension crisis, syncope
- Bullous dermatosis (rare), Stevens-Johnson syndrome (rare)
- Agranulocytosis, aplastic anemia, leukopenia
- Anaphylaxis (rare)
Warnings
Contraindications
Hypersensitivity or idiosyncratic reactions to drug or related compounds such as carisoprodol, mebutamate, tybamate, or carbromal
Acute intermittent porphyria
Cautions
The lowest effective dose should be administered, particularly to elderly and/or debilitated patients, in order to preclude oversedation
The possibility of suicide attempts should be considered and the least amount of drug feasible dispensed at any one time
Meprobamate is metabolized in the liver and excreted by the kidney; to avoid excess accumulation, exercise caution in administration to patients with compromised liver or kidney function
Meprobamate occasionally may precipitate seizures in epileptic patients
Patients should be warned that therapy may impair mental and/or physical abilities required for performance of potentially hazardous tasks such as driving or operating machinery
Drug dependence
- Physical dependence, psychological dependence, and abuse reported; when chronic intoxication from prolonged use occurs, usually involves ingestion of greater than recommended doses and manifested by ataxia, slurred speech, and vertigo; careful supervision of dose and amounts prescribed advised, as well as avoidance of prolonged administration, especially for alcoholics and other patients with a known propensity for taking excessive quantities of drugs
- Sudden withdrawal of drug after prolonged and excessive use may precipitate recurrence of pre-existing symptoms such as anxiety, anorexia, insomnia, or withdrawal reactions such as vomiting, ataxia, tremors, muscle twitching, confusional states, hallucinosis, and rarely, convulsive seizures
- Such seizures are more likely to occur in persons with central nervous system damage or pre-existent or latent convulsive disorders; onset of withdrawal symptoms occurs usually within 12-48 hr after discontinuation of meprobamate; symptoms usually cease within next 12-48 hr
- When excessive dosage has continued for weeks or months, dosage should be reduced gradually over period of one or two weeks rather than abruptly stopped; alternatively, a long-acting barbiturate may be substituted, then gradually withdrawn
Drug interaction overview
- Since effects of meprobamate and alcohol or meprobamate and other CNS depressants or psychotropic drugs may be additive, exercise appropriate caution with patients who take more than one of these agents simultaneously
Pregnancy & Lactation
Pregnancy
An increased risk of congenital malformations associated with use of minor tranquilizers (meprobamate, chlordiazepoxide, and diazepam) during first trimester of pregnancy suggested in several studies
Because use of these drugs is rarely a matter of urgency, their use during this period should almost always be avoided; the possibility that a woman of childbearing potential may be pregnant at time of institution of therapy should be considered
Patients should be advised that if they become pregnant during therapy or intend to become pregnant they should communicate with their physician about the desirability of discontinuing the drug
Meprobamate passes the placental barrier; it is present in umbilical cord blood at or near maternal plasma levels
Lactation
Present in breast milk of lactating mothers at concentrations two to four times that of maternal plasma; when use of meprobamate is contemplated in breastfeeding patients, the drug's higher concentration in breast milk as compared to maternal plasma should be considered
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Carbamate derivative; inhibitory effects in thalamus, limbic system; may inhibit multineural spinal reflexes
Mild sedative, anticonvulsant, muscular relaxant effects
Pharmacokinetics
Absorption: well-absorbed from GI tract
Half-Life: 6-16 hr
Onset: <1 hr
Peak plasma time: 1-3hr
Peak plasma concentration: 5-30 mcg/mL (400 mg dose)
Protein Bound: 20%
Metabolism: Liver
Metabolites: Inactive
Excretion: Urine (8-20%); feces (10%)
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| meprobamate oral - | 400 mg tablet |  | |
| meprobamate oral - | 200 mg tablet |  | |
| meprobamate oral - | 400 mg tablet |  | |
| meprobamate oral - | 200 mg tablet |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
meprobamate oral
MEPROBAMATE - ORAL
(meh-PRO-buh-mate)
COMMON BRAND NAME(S): Equanil
USES: This medication is used short-term to treat symptoms of anxiety and nervousness. It acts on certain centers of the brain to help calm your nervous system.
HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually 2 to 4 times daily. The dosage is based on your age, medical condition, and response to treatment.Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.If you suddenly stop using this medication, you may have withdrawal symptoms (such as vomiting, shakiness, confusion, and rarely seizures). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used meprobamate for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.When this medication is used for a long time, it may not work as well. Your doctor may need to increase your dose or change your medication. Talk with your doctor if this medication stops working well.Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.Tell your doctor if your condition lasts or gets worse.
SIDE EFFECTS: Drowsiness, dizziness, headache, excitement, nausea, vomiting, and diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: numbness/tingling/swelling of arms/legs, fast/irregular heartbeat, fainting, signs of infection (such as sore throat that doesn't go away, fever), easy bruising/bleeding, signs of kidney problems (such as change in the amount of urine), unusual tiredness.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking meprobamate, tell your doctor or pharmacist if you are allergic to it; or to carisoprodol, mebutamate, tybamate, or carbromal; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain liver/blood disorder (porphyria), kidney disease, liver disease, brain disorders (such as seizures, brain damage), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol).This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Older adults may be more sensitive to the side effects of this drug, especially drowsiness and addiction. Drowsiness can increase the risk of falling.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Tell your doctor or pharmacist if you are taking other products that cause drowsiness, including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol), and opioid pain relievers (such as codeine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: clumsiness, trouble speaking, severe dizziness/drowsiness, or slow/shallow breathing.
NOTES: Do not share this medication with others. Sharing it is against the law.Keep all medical appointments. Your doctor will periodically monitor your progress or check for side effects. Consult your doctor for more details.
MISSED DOSE: If you are taking this on a regular schedule and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised October 2022. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
