meprobamate (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

tablet: Schedule IV

  • 200mg
  • 400mg

Anxiety

1200-1600 mg/day PO divided q6-8hr; not to exceed 2.4 g/day

Preoperative Sedation

400 mg PO before the procedure

Renal Impairment

CrCl 10-50 mL/min: Change frequency of administration to every 9-12hr

CrCl <10 mL/min: Change frequency of administration to 12-18hr

Hepatic Impairment

Use caution

Dosage Forms & Strengths

tablet: Schedule IV

  • 200mg
  • 400mg

Anxiety

<6 years old: Not recommended

6-12 years old: 100-200 mg PO q8-12hr

>12 years old: 1200-1600 mg/day PO divided q8-12hr; not to exceed 2.4 g/day

Preoperative Sedation

200 mg PO prior to procedure

Not drug of choice in elderly because of potential physical and psychological dependence

Use lowest effective dose to avoid oversedation

Anxiety

Lower initial dose; adjust more gradually; 200 mg PO q8-12hr

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Interactions

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              Serious - Use Alternative (6)

              • benzhydrocodone/acetaminophen

                benzhydrocodone/acetaminophen, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              • calcium/magnesium/potassium/sodium oxybates

                meprobamate, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              • hydrocodone

                hydrocodone, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              • metoclopramide intranasal

                meprobamate, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

              • sodium oxybate

                meprobamate, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              • sufentanil SL

                sufentanil SL, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              Monitor Closely (174)

              • albuterol

                meprobamate increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • alfentanil

                alfentanil and meprobamate both increase sedation. Use Caution/Monitor.

              • alprazolam

                alprazolam and meprobamate both increase sedation. Use Caution/Monitor.

              • amitriptyline

                amitriptyline and meprobamate both increase sedation. Use Caution/Monitor.

              • amobarbital

                amobarbital and meprobamate both increase sedation. Use Caution/Monitor.

              • amoxapine

                amoxapine and meprobamate both increase sedation. Use Caution/Monitor.

              • apomorphine

                apomorphine and meprobamate both increase sedation. Use Caution/Monitor.

              • arformoterol

                meprobamate increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • aripiprazole

                aripiprazole and meprobamate both increase sedation. Use Caution/Monitor.

              • armodafinil

                meprobamate increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • azelastine

                azelastine and meprobamate both increase sedation. Use Caution/Monitor.

              • baclofen

                baclofen and meprobamate both increase sedation. Use Caution/Monitor.

              • belladonna and opium

                belladonna and opium and meprobamate both increase sedation. Use Caution/Monitor.

              • benperidol

                benperidol and meprobamate both increase sedation. Use Caution/Monitor.

              • benzphetamine

                meprobamate increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • brexanolone

                brexanolone, meprobamate. Either increases toxicity of the other by sedation. Use Caution/Monitor.

              • brompheniramine

                brompheniramine and meprobamate both increase sedation. Use Caution/Monitor.

              • buprenorphine

                buprenorphine and meprobamate both increase sedation. Use Caution/Monitor.

              • buprenorphine buccal

                buprenorphine buccal and meprobamate both increase sedation. Use Caution/Monitor.

              • buprenorphine, long-acting injection

                meprobamate increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.

              • butabarbital

                butabarbital and meprobamate both increase sedation. Use Caution/Monitor.

              • butalbital

                butalbital and meprobamate both increase sedation. Use Caution/Monitor.

              • butorphanol

                butorphanol and meprobamate both increase sedation. Use Caution/Monitor.

              • caffeine

                meprobamate increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • carbinoxamine

                carbinoxamine and meprobamate both increase sedation. Use Caution/Monitor.

              • carisoprodol

                carisoprodol and meprobamate both increase sedation. Use Caution/Monitor.

              • chloral hydrate

                chloral hydrate and meprobamate both increase sedation. Use Caution/Monitor.

              • chlordiazepoxide

                chlordiazepoxide and meprobamate both increase sedation. Use Caution/Monitor.

              • chlorpheniramine

                chlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.

              • chlorpromazine

                chlorpromazine and meprobamate both increase sedation. Use Caution/Monitor.

              • chlorzoxazone

                chlorzoxazone and meprobamate both increase sedation. Use Caution/Monitor.

              • cinnarizine

                cinnarizine and meprobamate both increase sedation. Use Caution/Monitor.

              • clemastine

                clemastine and meprobamate both increase sedation. Use Caution/Monitor.

              • clobazam

                meprobamate, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression).

              • clomipramine

                clomipramine and meprobamate both increase sedation. Use Caution/Monitor.

              • clonazepam

                clonazepam and meprobamate both increase sedation. Use Caution/Monitor.

              • clorazepate

                clorazepate and meprobamate both increase sedation. Use Caution/Monitor.

              • clozapine

                clozapine and meprobamate both increase sedation. Use Caution/Monitor.

              • codeine

                codeine and meprobamate both increase sedation. Use Caution/Monitor.

              • cyclizine

                cyclizine and meprobamate both increase sedation. Use Caution/Monitor.

              • cyclobenzaprine

                cyclobenzaprine and meprobamate both increase sedation. Use Caution/Monitor.

              • cyproheptadine

                cyproheptadine and meprobamate both increase sedation. Use Caution/Monitor.

              • dantrolene

                dantrolene and meprobamate both increase sedation. Use Caution/Monitor.

              • desipramine

                desipramine and meprobamate both increase sedation. Use Caution/Monitor.

              • dexchlorpheniramine

                dexchlorpheniramine and meprobamate both increase sedation. Use Caution/Monitor.

              • dexfenfluramine

                meprobamate increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dexmedetomidine

                dexmedetomidine and meprobamate both increase sedation. Use Caution/Monitor.

              • dexmethylphenidate

                meprobamate increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dextroamphetamine

                meprobamate increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dextromoramide

                dextromoramide and meprobamate both increase sedation. Use Caution/Monitor.

              • diamorphine

                diamorphine and meprobamate both increase sedation. Use Caution/Monitor.

              • diazepam

                diazepam and meprobamate both increase sedation. Use Caution/Monitor.

              • diethylpropion

                meprobamate increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • difenoxin hcl

                difenoxin hcl and meprobamate both increase sedation. Use Caution/Monitor.

              • dimenhydrinate

                dimenhydrinate and meprobamate both increase sedation. Use Caution/Monitor.

              • diphenhydramine

                diphenhydramine and meprobamate both increase sedation. Use Caution/Monitor.

              • diphenoxylate hcl

                diphenoxylate hcl and meprobamate both increase sedation. Use Caution/Monitor.

              • dipipanone

                dipipanone and meprobamate both increase sedation. Use Caution/Monitor.

              • dobutamine

                meprobamate increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dopamine

                meprobamate increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • dopexamine

                meprobamate increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • doxepin

                doxepin and meprobamate both increase sedation. Use Caution/Monitor.

              • doxylamine

                doxylamine and meprobamate both increase sedation. Use Caution/Monitor.

              • droperidol

                droperidol and meprobamate both increase sedation. Use Caution/Monitor.

              • ephedrine

                meprobamate increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • epinephrine

                meprobamate increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • epinephrine racemic

                meprobamate increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • estazolam

                estazolam and meprobamate both increase sedation. Use Caution/Monitor.

              • ethanol

                ethanol and meprobamate both increase sedation. Use Caution/Monitor.

                meprobamate, ethanol. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive CNS depression.

              • etomidate

                etomidate and meprobamate both increase sedation. Use Caution/Monitor.

              • fenfluramine

                meprobamate increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • fluphenazine

                fluphenazine and meprobamate both increase sedation. Use Caution/Monitor.

              • flurazepam

                flurazepam and meprobamate both increase sedation. Use Caution/Monitor.

              • formoterol

                meprobamate increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • gabapentin

                gabapentin, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

              • gabapentin enacarbil

                gabapentin enacarbil, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

              • haloperidol

                haloperidol and meprobamate both increase sedation. Use Caution/Monitor.

              • hydromorphone

                hydromorphone and meprobamate both increase sedation. Use Caution/Monitor.

              • hydroxyzine

                hydroxyzine and meprobamate both increase sedation. Use Caution/Monitor.

              • iloperidone

                iloperidone and meprobamate both increase sedation. Use Caution/Monitor.

              • imipramine

                imipramine and meprobamate both increase sedation. Use Caution/Monitor.

              • isoproterenol

                meprobamate increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ketamine

                ketamine and meprobamate both increase sedation. Use Caution/Monitor.

              • ketotifen, ophthalmic

                ketotifen, ophthalmic and meprobamate both increase sedation. Use Caution/Monitor.

              • lasmiditan

                lasmiditan, meprobamate. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

              • lemborexant

                lemborexant, meprobamate. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

              • levalbuterol

                meprobamate increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • levorphanol

                levorphanol and meprobamate both increase sedation. Use Caution/Monitor.

              • lisdexamfetamine

                meprobamate increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • lofepramine

                lofepramine and meprobamate both increase sedation. Use Caution/Monitor.

              • lofexidine

                lofexidine and meprobamate both increase sedation. Use Caution/Monitor.

              • loprazolam

                loprazolam and meprobamate both increase sedation. Use Caution/Monitor.

              • lorazepam

                lorazepam and meprobamate both increase sedation. Use Caution/Monitor.

              • lormetazepam

                lormetazepam and meprobamate both increase sedation. Use Caution/Monitor.

              • loxapine

                loxapine and meprobamate both increase sedation. Use Caution/Monitor.

              • loxapine inhaled

                loxapine inhaled and meprobamate both increase sedation. Use Caution/Monitor.

              • lurasidone

                lurasidone, meprobamate. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

              • maprotiline

                maprotiline and meprobamate both increase sedation. Use Caution/Monitor.

              • marijuana

                marijuana and meprobamate both increase sedation. Use Caution/Monitor.

              • melatonin

                melatonin and meprobamate both increase sedation. Use Caution/Monitor.

              • meperidine

                meperidine and meprobamate both increase sedation. Use Caution/Monitor.

              • metaproterenol

                meprobamate increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • metaxalone

                metaxalone and meprobamate both increase sedation. Use Caution/Monitor.

              • methadone

                methadone and meprobamate both increase sedation. Use Caution/Monitor.

              • methamphetamine

                meprobamate increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • methocarbamol

                methocarbamol and meprobamate both increase sedation. Use Caution/Monitor.

              • methylenedioxymethamphetamine

                meprobamate increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • midazolam

                midazolam and meprobamate both increase sedation. Use Caution/Monitor.

              • midodrine

                meprobamate increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • mirtazapine

                meprobamate and mirtazapine both increase sedation. Use Caution/Monitor.

              • modafinil

                meprobamate increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • morphine

                morphine and meprobamate both increase sedation. Use Caution/Monitor.

              • motherwort

                meprobamate and motherwort both increase sedation. Use Caution/Monitor.

              • moxonidine

                meprobamate and moxonidine both increase sedation. Use Caution/Monitor.

              • nabilone

                meprobamate and nabilone both increase sedation. Use Caution/Monitor.

              • nalbuphine

                nalbuphine and meprobamate both increase sedation. Use Caution/Monitor.

              • norepinephrine

                meprobamate increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • nortriptyline

                nortriptyline and meprobamate both increase sedation. Use Caution/Monitor.

              • olanzapine

                olanzapine and meprobamate both increase sedation. Use Caution/Monitor.

              • oliceridine

                oliceridine, meprobamate. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

              • opium tincture

                opium tincture and meprobamate both increase sedation. Use Caution/Monitor.

              • orphenadrine

                orphenadrine and meprobamate both increase sedation. Use Caution/Monitor.

              • oxazepam

                oxazepam and meprobamate both increase sedation. Use Caution/Monitor.

              • oxycodone

                oxycodone and meprobamate both increase sedation. Use Caution/Monitor.

              • oxymorphone

                oxymorphone and meprobamate both increase sedation. Use Caution/Monitor.

              • paliperidone

                paliperidone and meprobamate both increase sedation. Use Caution/Monitor.

              • papaveretum

                papaveretum and meprobamate both increase sedation. Use Caution/Monitor.

              • papaverine

                meprobamate and papaverine both increase sedation. Use Caution/Monitor.

              • pentazocine

                pentazocine and meprobamate both increase sedation. Use Caution/Monitor.

              • pentobarbital

                pentobarbital and meprobamate both increase sedation. Use Caution/Monitor.

              • perphenazine

                perphenazine and meprobamate both increase sedation. Use Caution/Monitor.

              • phendimetrazine

                meprobamate increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenobarbital

                phenobarbital and meprobamate both increase sedation. Use Caution/Monitor.

              • phentermine

                meprobamate increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenylephrine

                meprobamate increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • phenylephrine PO

                meprobamate increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

              • pholcodine

                meprobamate and pholcodine both increase sedation. Use Caution/Monitor.

              • pimozide

                pimozide and meprobamate both increase sedation. Use Caution/Monitor.

              • pirbuterol

                meprobamate increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • pregabalin

                pregabalin, meprobamate. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor for respiratory depression and sedation.

              • primidone

                primidone and meprobamate both increase sedation. Use Caution/Monitor.

              • prochlorperazine

                prochlorperazine and meprobamate both increase sedation. Use Caution/Monitor.

              • promethazine

                promethazine and meprobamate both increase sedation. Use Caution/Monitor.

              • propofol

                propofol and meprobamate both increase sedation. Use Caution/Monitor.

              • propylhexedrine

                meprobamate increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • protriptyline

                protriptyline and meprobamate both increase sedation. Use Caution/Monitor.

              • quazepam

                quazepam and meprobamate both increase sedation. Use Caution/Monitor.

              • quetiapine

                quetiapine and meprobamate both increase sedation. Use Caution/Monitor.

              • ramelteon

                meprobamate and ramelteon both increase sedation. Use Caution/Monitor.

              • risperidone

                risperidone and meprobamate both increase sedation. Use Caution/Monitor.

              • salmeterol

                meprobamate increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • scullcap

                meprobamate and scullcap both increase sedation. Use Caution/Monitor.

              • secobarbital

                secobarbital and meprobamate both increase sedation. Use Caution/Monitor.

              • sevoflurane

                sevoflurane and meprobamate both increase sedation. Use Caution/Monitor.

              • shepherd's purse

                meprobamate and shepherd's purse both increase sedation. Use Caution/Monitor.

              • stiripentol

                stiripentol, meprobamate. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

              • sufentanil

                sufentanil and meprobamate both increase sedation. Use Caution/Monitor.

              • tapentadol

                tapentadol and meprobamate both increase sedation. Use Caution/Monitor.

              • temazepam

                temazepam and meprobamate both increase sedation. Use Caution/Monitor.

              • terbutaline

                meprobamate increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • thioridazine

                thioridazine and meprobamate both increase sedation. Use Caution/Monitor.

              • thiothixene

                thiothixene and meprobamate both increase sedation. Use Caution/Monitor.

              • topiramate

                meprobamate and topiramate both increase sedation. Modify Therapy/Monitor Closely.

              • tramadol

                tramadol and meprobamate both increase sedation. Use Caution/Monitor.

              • trazodone

                trazodone and meprobamate both increase sedation. Use Caution/Monitor.

              • triazolam

                triazolam and meprobamate both increase sedation. Use Caution/Monitor.

              • triclofos

                triclofos and meprobamate both increase sedation. Use Caution/Monitor.

              • trifluoperazine

                trifluoperazine and meprobamate both increase sedation. Use Caution/Monitor.

              • trimipramine

                trimipramine and meprobamate both increase sedation. Use Caution/Monitor.

              • triprolidine

                triprolidine and meprobamate both increase sedation. Use Caution/Monitor.

              • xylometazoline

                meprobamate increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • yohimbine

                meprobamate increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

              • ziconotide

                meprobamate and ziconotide both increase sedation. Use Caution/Monitor.

              • ziprasidone

                ziprasidone and meprobamate both increase sedation. Use Caution/Monitor.

              Minor (3)

              • brimonidine

                brimonidine increases effects of meprobamate by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

              • eucalyptus

                eucalyptus and meprobamate both increase sedation. Minor/Significance Unknown.

              • sage

                meprobamate and sage both increase sedation. Minor/Significance Unknown.

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              Adverse Effects

              Frequency Not Defined

              Common

              • Abnormal ECG, palpitations, tachyarrhythmia
              • Asthenia, ataxia, dizziness, EEG abnormality, euphoria, fast, excitement, paradoxical, headache, paresthesia, slurred speech, somnolence, vertigo
              • Hives, maculopapular eruption, erythematous
              • Diarrhea, nausea, vomiting
              • Disorder of accommodation (ocular)

              Serious

              • Cardiac dysrhythmia, hypotension crisis, syncope
              • Bullous dermatosis (rare), Stevens-Johnson syndrome (rare)
              • Agranulocytosis, aplastic anemia, leukopenia
              • Anaphylaxis (rare)
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              Warnings

              Contraindications

              Hypersensitivity, allergy to related drugs (eg, carisoprodol)

              History of porphyria

              Cautions

              Hypersensitivity may occur

              May impair physical or mental abilities due to CNS depression

              Secreted into breast milk; avoid during breastfeeding

              Caution in patientw with depression or suicidal tendencies

              Caution in hepatic/renal impairment or seizure disorder

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              Pregnancy & Lactation

              Pregnancy Category: D

              Lactation: secreted into breast milk at 2-4x plasma concentration; avoid

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Carbamate derivative; inhibitory effects in thalamus, limbic system; may inhibit multineural spinal reflexes

              Mild sedative, anticonvulsant, muscular relaxant effects

              Pharmacokinetics

              Absorption: well-absorbed from GI tract

              Half-Life: 6-16 hr

              Onset: <1 hr

              Peak plasma time: 1-3hr

              Peak plasma concentration: 5-30 mcg/mL (400 mg dose)

              Protein Bound: 20%

              Metabolism: Liver

              Metabolites: Inactive

              Excretion: Urine (8-20%); feces (10%)

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              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              meprobamate oral
              -
              400 mg tablet
              meprobamate oral
              -
              200 mg tablet
              meprobamate oral
              -
              400 mg tablet
              meprobamate oral
              -
              200 mg tablet

              Copyright © 2010 First DataBank, Inc.

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              Patient Handout

              Patient Education
              meprobamate oral

              MEPROBAMATE - ORAL

              (meh-PRO-buh-mate)

              COMMON BRAND NAME(S): Equanil

              USES: This medication is used short-term to treat symptoms of anxiety and nervousness. It acts on certain centers of the brain to help calm your nervous system.

              HOW TO USE: Take this medication by mouth with or without food, usually 2 to 4 times daily or as directed by your doctor.Dosage is based on your age, medical condition, and response to treatment. Adults should not take more than 2400 milligrams in a 24-hour period.Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased.If you suddenly stop using this medication, you may have withdrawal symptoms (such as vomiting, shakiness, confusion, and rarely seizures). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used meprobamate for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.When this medication is used for a long time, it may not work as well. Your doctor may need to increase your dose or change your medication. Talk with your doctor if this medication stops working well.Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.Tell your doctor if your condition persists or worsens.

              SIDE EFFECTS: Drowsiness, dizziness, headache, excitement, nausea, vomiting, and diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these unlikely but serious side effects occur: numbness/tingling/swelling of arms/legs.Tell your doctor right away if any of these rare but very serious side effects occur: fast/irregular heartbeat, fainting, signs of infection (such as fever, persistent sore throat), easy bruising/bleeding, signs of kidney problems (such as change in the amount of urine), unusual tiredness.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: Before taking meprobamate, tell your doctor or pharmacist if you are allergic to it; or to carisoprodol, mebutamate, tybamate, or carbromal; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain liver/blood disorder (porphyria), kidney disease, liver disease, brain disorders (such as seizures, brain damage), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol).This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Older adults may be more sensitive to the side effects of this drug, especially drowsiness and addiction. Drowsiness can increase the risk of falling.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Tell your doctor or pharmacist if you are taking other products that cause drowsiness, including alcohol, marijuana (cannabis), antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants (such as carisoprodol), and opioid pain relievers (such as codeine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: clumsiness, trouble speaking, severe dizziness/drowsiness, or slow/shallow breathing.

              NOTES: Do not share this medication with others. Sharing it is against the law.Keep all medical appointments. Your doctor will periodically monitor your progress or check for side effects. Consult your doctor for more details.

              MISSED DOSE: If you are taking this on a regular schedule and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

              STORAGE: Store at room temperature away from light and moisture. See packaging or consult your pharmacist for the exact temperature range. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

              Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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              Formulary

              FormularyPatient Discounts

              Adding plans allows you to compare formulary status to other drugs in the same class.

              To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

              Adding plans allows you to:

              • View the formulary and any restrictions for each plan.
              • Manage and view all your plans together – even plans in different states.
              • Compare formulary status to other drugs in the same class.
              • Access your plan list on any device – mobile or desktop.

              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.