Methazolamide dosing, indications, interactions, adverse effects, and more

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Sections methazolamide
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
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Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

tablet

25mg
50mg

Glaucoma

50-100 mg PO BID/TID

Other Indications & Uses

Off-label: Altitude sickness

Safety and effecacy not established

Interaction Checker

Enter a drug name and methazolamide

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No Interactions Found

Interactions Found

Contraindicated

Serious - Use Alternative

Significant - Monitor Closely

Minor

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>10%

Drowsiness

Paresthesias

Anorexia

Nausea

Vomiting

Frequency Not Defined

Sulfonamide-type rxns

Acidosis

Electrolyte imbalance

Glycosuria

Hematuria

Thrombocytopenia

Hepatic dysfunction

Tinnitus

Contraindications

Hypokalemia, hyponatremia, hyperchloremic acidosis, cirrhosis, severe liver or renal impairment, adrenal gland failure

Cautions

COPD, emphysema, concomitant high-dose aspirin or steroid therapy, or hepatic insufficiency

ADRs common to sulfonamide derivatives

Stevens-Johnson syndrome and toxic epidermal necrolysis may occur

Pregnancy & Lactation

Pregnancy Category: C

Lactation: not known if crosses in to breast milk, avoid

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Carbonic anhydrase inhibitor, decr rate of aqueous humor formation and decreased IOP

Pharmacokinetics

Half-life: 14 d

Onset: 2-4 hr

Max Effect: 6-8 hr

Duration: 10-18 hr

Bioavailability: absorbed more slowly than acetazolamide

Excretion: urine 15%

Images

Patient Handout

Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Create Your List of Plans

Adding plans allows you to:

View the formulary and any restrictions for each plan.
Manage and view all your plans together – even plans in different states.
Compare formulary status to other drugs in the same class.
Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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Sections methazolamide
Dosing & Uses
Interactions
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

methazolamide (Rx)