methotrexate intravitreal (Pending FDA Approval)

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Dosing & Uses

Vitreoretinal Lymphoma

Pending FDA approval for primary vitreoretinal lymphoma

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Pharmacology

Mechanism of Action

Inhibits dihydrofolic acid reductase; inhibits purine and thymidylic acid synthesis, which in turn interferes with DNA synthesis, repair, and cellular replication; cell cycle specific for S phase of cycle

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.