Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 200mg/mL
tablet extended release
- 535mg (64mg elemental)
RDA (Elemental Magnesium)
Males: 400-420 mg PO qDay
18-30 (Females)
- 310 mg PO qDay
- Pregnancy: 350 mg PO qDay
- Lactation: 310 mg PO qDay
>30 years (Females)
- 320mg/day
- Pregnant women: 360 mg/day
- Lactating women: 320 mg/day
Hypomagnesemia
4 g (in 250 mL D5W) IV infusion; no more than 3 mL/min
Usual Range: 1- 40 g IV qDay
Use serum levels as guide to continue therapy
Dosage Forms & Strengths
injectable solution
- 200mg/mL
tablet extended release
- 535mg (64mg elemental)
RDA
<6 months: 30 mg/day
6-12 months: 75 mg/day
1-3 years: 80 mg/day
3-8 years: 130 mg/day
8-13 years: 240 mg/day
13-18 years: 410 mg/day (men); 360 mg/day (women); 400 mg/day (pregnant women); 360 mg/day (lactating women)
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (0)
Serious - Use Alternative (7)
- baloxavir marboxil
magnesium chloride will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Avoid or Use Alternate Drug. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Human studies not conducted.
- demeclocycline
magnesium chloride decreases levels of demeclocycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.
- doxycycline
magnesium chloride decreases levels of doxycycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.
- eltrombopag
magnesium chloride decreases levels of eltrombopag by inhibition of GI absorption. Applies only to oral form of both agents. Contraindicated. Separate by at least 4 hours.
- minocycline
magnesium chloride decreases levels of minocycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.
- oxytetracycline
magnesium chloride decreases levels of oxytetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.
- tetracycline
magnesium chloride decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.
Monitor Closely (13)
- cabotegravir
magnesium chloride will decrease the level or effect of cabotegravir by cation binding in GI tract. Modify Therapy/Monitor Closely. Administer polyvalent cation products at least 2 hr before or 4 hr after taking oral cabotegravir.
- ciprofloxacin
magnesium chloride decreases levels of ciprofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Use alternatives if available.
- deferiprone
magnesium chloride decreases levels of deferiprone by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations.
- delafloxacin
magnesium chloride will decrease the level or effect of delafloxacin by cation binding in GI tract. Modify Therapy/Monitor Closely. Oral delafloxacin form chelates with alkaline earth and transition metal cations. Administer oral delafloxacin at least 2 hr before or 6 hr after these agents.
- fleroxacin
magnesium chloride decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
- gemifloxacin
magnesium chloride decreases levels of gemifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
- levofloxacin
magnesium chloride decreases levels of levofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
- moxifloxacin
magnesium chloride decreases levels of moxifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
- ofloxacin
magnesium chloride decreases levels of ofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
- omadacycline
magnesium chloride will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.
- penicillamine
magnesium chloride decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.
- rilpivirine
magnesium chloride decreases levels of rilpivirine by increasing gastric pH. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Coadministration of antacids with rilpivirine may cause significant decreases in rilpivirine plasma concentrations because of increased gastric pH. If antacids must be administered, they should given at least 2 hr before or at least 4 hr after rilpivirine.
- sarecycline
magnesium chloride will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.
Minor (42)
- amikacin
amikacin decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- amiloride
amiloride increases levels of magnesium chloride by decreasing renal clearance. Minor/Significance Unknown.
- amphotericin B deoxycholate
amphotericin B deoxycholate decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- bazedoxifene/conjugated estrogens
bazedoxifene/conjugated estrogens decreases levels of magnesium chloride by Other (see comment). Minor/Significance Unknown. Comment: Magnesium shifted from blood to tissue storage.
- bendroflumethiazide
bendroflumethiazide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- bumetanide
bumetanide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- calcitonin salmon
calcitonin salmon increases levels of magnesium chloride by decreasing renal clearance. Minor/Significance Unknown.
- chlorothiazide
chlorothiazide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- chlorthalidone
chlorthalidone decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- conjugated estrogens
conjugated estrogens decreases levels of magnesium chloride by Other (see comment). Minor/Significance Unknown. Comment: Magnesium shifted from blood to tissue storage.
- conjugated estrogens, vaginal
conjugated estrogens, vaginal decreases levels of magnesium chloride by Other (see comment). Minor/Significance Unknown. Comment: Magnesium shifted from blood to tissue storage.
- cyclopenthiazide
cyclopenthiazide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- cyclosporine
cyclosporine decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- dextrose
dextrose decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- dextrose (Antidote)
dextrose (Antidote) decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- digoxin
digoxin decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- doxercalciferol
doxercalciferol increases levels of magnesium chloride by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- drospirenone
drospirenone increases levels of magnesium chloride by decreasing renal clearance. Minor/Significance Unknown.
- estradiol
estradiol decreases levels of magnesium chloride by Other (see comment). Minor/Significance Unknown. Comment: Magnesium shifted from blood to tissue storage.
- estrogens conjugated synthetic
estrogens conjugated synthetic decreases levels of magnesium chloride by Other (see comment). Minor/Significance Unknown. Comment: Magnesium shifted from blood to tissue storage.
- estrogens esterified
estrogens esterified decreases levels of magnesium chloride by Other (see comment). Minor/Significance Unknown. Comment: Magnesium shifted from blood to tissue storage.
- estropipate
estropipate decreases levels of magnesium chloride by Other (see comment). Minor/Significance Unknown. Comment: Magnesium shifted from blood to tissue storage.
- ethacrynic acid
ethacrynic acid decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- furosemide
furosemide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- gentamicin
gentamicin decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- glucagon intranasal
glucagon intranasal increases levels of magnesium chloride by decreasing renal clearance. Minor/Significance Unknown.
- hydrochlorothiazide
hydrochlorothiazide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- ibandronate
magnesium chloride decreases levels of ibandronate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- indapamide
indapamide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- mannitol
mannitol decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- mestranol
mestranol decreases levels of magnesium chloride by Other (see comment). Minor/Significance Unknown. Comment: Magnesium shifted from blood to tissue storage.
- methyclothiazide
methyclothiazide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- metolazone
metolazone decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- neomycin PO
neomycin PO decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- nitrofurantoin
magnesium chloride decreases levels of nitrofurantoin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.
- paromomycin
paromomycin decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- sodium polystyrene sulfonate
sodium polystyrene sulfonate increases levels of magnesium chloride by decreasing renal clearance. Minor/Significance Unknown. Risk of alkalosis.
- spironolactone
spironolactone increases levels of magnesium chloride by decreasing renal clearance. Minor/Significance Unknown.
- streptomycin
streptomycin decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- tobramycin
tobramycin decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- torsemide
torsemide decreases levels of magnesium chloride by increasing renal clearance. Minor/Significance Unknown.
- triamterene
triamterene increases levels of magnesium chloride by decreasing renal clearance. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Respiratory depression
Hypothermia
Flushing
Significant decrease in blood pressure
Stupor
Sweating
Warnings
Contraindications
Renal impairment
Significant myocardial disease
Comatose patients
Cautions
Administer with caution if flushing and sweating occurs
A preparation of a calcium salt should be readily available for intravenous injection to counteract potential serious signs of magnesium intoxication
As long as deep tendon reflexes are active it is probable that the patient will not develop respiratory paralysis
Carefully monitor respiration and blood pressure during and after administration of magnesium chloride injection
Contains benzyl alcohol (toxic in children)
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Excreted in breast milk; use caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Acts as cofactor in numerous enzymatic reactions involving protein synthesis and carbohydrate metabolism; depresses CNS, blocks peripheral neuromuscular transmission, produces anticonvulsant effects
Pharmacokinetics
Distribution: 50-60% (Bone ); 1-2% (extracellular fluid)
Protein binding: 30% (albumin)
Excretion: Urine (as magnesium)
Absorption: Inversely proportional to amount ingested (15-36% at thigh doses and 40-60% at controlled dietary levels)
Administration
IV Preparation
4 g diluted in 250 mL D5W
10 g multidose vial
IV Administration
Do not use if precipitate present
NMT 3 mL/min
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| magnesium chloride injection - | 200 mg/mL (20 %) vial |  | |
| Mag 64 oral - | 64 mg tablet |  | |
| Slow-Mag oral - | 71.5 mg tablet |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
magnesium chloride injection
NO MONOGRAPH AVAILABLE AT THIS TIME
USES: Consult your pharmacist.
HOW TO USE: Consult your pharmacist.
SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Consult your pharmacist.
DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: No monograph available at this time.
MISSED DOSE: Consult your pharmacist.
STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
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