Dosing & Uses
Dosage Forms & Strengths
acetaminophen/pamabrom
caplet
- 500mg/25mg
tablet
- 325mg/25mg
Analgesia/Menstrual Cramps
1-2 caplets or tablets PO q4-6hr PRN; not to exceed 8 caplets/tablets for 24 hr
Dosage Forms & Strengths
acetaminophen/pamabrom
caplet
- 500mg/25mg
tablet
- 325mg/25mg
Analgesia/Menstrual Cramps
<12 years: Safety and efficacy not established
≥12 years: 1-2 caplets or tablets PO q4-6hr PRN; not to exceed 8 caplets/tablets per 24 hr
Adverse Effects
Frequency Not Defined
Angioedema
Laryngeal edema
Pruritic maculopapular rash
Urticaria
Agranulocytosis
Leukopenia
Neutropenia
Pancytopenia
Thrombocytopenia
Thrombocytopenic purpura
Hepatotoxicity
Anaphylactoid reaction
May increase uric acid, chloride, glucose
May decrease sodium, calcium, bicarbonate
Warnings
Contraindications
Hypersensitivity
Hepatitis or severe hepatic/renal impairment
Cautions
Risk of hepatotoxicity; higher in alcoholics, or w/ use of more than one acetaminophen-containing product
Caution in G6PD deficiency
Hepatic impairment or consumption of 3 or more alcoholic beverages/day may increase risk for liver damage (associated with acetaminophen)
Acetaminophen: Risk for rare, but serious skin reactions that can be fatal; these reactions include Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP); symptoms may include skin redness, blisters and rash
Pregnancy & Lactation
Pregnancy category: C
Lactation: excreted in breast milk
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Acetaminophen: Inhibitis prostaglandin sythesis in CNS and may block peripheral pain impulse generation; acts on hypothalamus as antipyretic
Pamabrom: Weak diuretic action