Dosing & Uses
Dosage Forms & Strengths
powder for injection
- 20mg
Miosis During Ocular Surgery
0.5-2 mL of 1% solution intraocular instillation during surgery
Miosis occurs promptly and persists for approximately 10 minutes
Administration
Reconstitute vial with 2 mL supplied diluent to obtain 1% solution; use immediately
Instill gently into anterior chamber of eye with suitable atraumatic cannula
May use 2% pilocarpine or 0.25% physostigmine topically immediately after surgery before application of dressing to maintain miosis
For cataract surgery, instill only after delivery of lens
Safety & efficacy not established
Adverse Effects
Frequency Not Defined
Ocular
- Corneal edema
- Corneal clouding
- Corneal decompensation
Systemic (Rare)
- Bradycardia
- Flushing
- Hypotension
- Breathing difficulty
- Sweating
Warnings
Cautions
Use reconstituted solution immediately; aqueous solution unstable
Instill gently; forceful jet may rupture the hyaloid, cause vitreous loss, or traumatize/perforate iris
Systemic effects (rare) can cause problems for patients with asthma, acute heart failure, GI spasm, peptic ulcer disease, urinary tract obstruction, acute heart failure, and hyperthyroidism
Pregnancy & Lactation
Pregnancy Category: C
Lactation: Excretion in milk unknown; use with caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Direct-acting parasympathomimetic neurotransmitter; causes contraction of sphincter muscles of the iris, which results in miosis and contraction of ciliary muscle and leads to accomodation spasm
Pharmacokinetics
Onset of action: Rapid
Duration: 6 hr
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Miochol-E intraocular - | 1 % (10 mg/mL) kit |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
acetylcholine chloride intraocular
NO MONOGRAPH AVAILABLE AT THIS TIME
USES: Consult your pharmacist.
HOW TO USE: Consult your pharmacist.
SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Consult your pharmacist.
DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: No monograph available at this time.
MISSED DOSE: Consult your pharmacist.
STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.
Information last revised July 2016. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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