molybdenum (Rx)

Brand and Other Names:Molypen

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

injection solution

  • 25mcg/mL

RDA

Males or females: 45 mcg/day

Pregnancy: 50 mcg/day

Lactating: 50 mcg/day

Supplementation in Patients Receiving TPN

20-120 mcg/day administered in TPN

Molybdenum Deficiency from Prolonged TPN Support

163 mcg/day added to TPN for 21 days shown to be effective

Dosage Forms & Strengths

injection solution

  • 25mcg/mL

RDA

<6 months: 2 mcg/day

6-12 months: 3 mcg/day

1-3 years: 17 mcg/day

3-8 years: 22 mcg/day

8-13 years: 34 mcg/day

>13 years: 43 mcg/day

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Interactions

Interaction Checker

and molybdenum

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (1)

              • baloxavir marboxil

                molybdenum will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Avoid or Use Alternate Drug. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Human studies not conducted.

              Monitor Closely (2)

              • omadacycline

                molybdenum will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

              • sarecycline

                molybdenum will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

              Minor (1)

              • fluoride

                fluoride, molybdenum. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Enhanced dental caries protection.

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              Adverse Effects

              Frequency Not Defined

              Gout-like symptoms (high dose)

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              Warnings

              Contraindications

              Copper deficient patients

              Undiluted injection into peripheral vein (risk of infusion phlebitis)

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              Pregnancy & Lactation

              Pregnancy Category: C

              Lactation: Detected in milk; use caution

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Cofactor in xanthine oxidase (uric acid formation), aldehyde oxidase (EtOH detoxification), sulfite oxidase (sulfite detoxification)

              Tetrathiomolybdate complexes with copper in GI tract & blood to decrease toxicity

              Pharmacokinetics

              Excretion: Urine (primarily); bile (minimal)

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              Patient Handout

              A Patient Handout is not currently available for this monograph.
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              Formulary

              FormularyPatient Discounts

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              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.