Dosing & Uses
Dosage Forms & Strengths
powder for reconstitution
- 3g/packet
Urinary Tract Infection (Acute Cystitis)
Acute cystitis caused by E. coli, E. faecalis
Women >18 years: 3 g PO once
Males >18 years: 3 g every 2-3 days for 3 doses
Preparation: Dissolve 1 packet (3 g) in 3-4 oz water
Prostatitis
3 g PO every 3 days for 21 days
Safety & efficacy not established
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
1-10%
Anorexia
Diarrhea
Epigastric
Discomfort
Headache
Nausea
Rash
Vomiting
<1%
Dizziness
Drowsiness
Fatigue
Pruritus
Warnings
Contraindications
Hypersensitivity
Pregnancy & Lactation
Pregnancy Category: B
Lactation: excreted in breast milk; not recommended
Pregnancy Categories
A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.
C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.
D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.
X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.
NA:Information not available.
Pharmacology
Absorption: well absorbed
Distribution: Vd: 2 L/kg; high concentrations in urine; well into other tissues; crosses maximally into CSF with inflamed meninges
Protein binding: < 3%
Bioavailability: 34-58%
Half-life Elimination
Normal renal function: 4-8 hr
CrCl <10 mL/min: 50 hr
Other Information
Time to peak, serum: 2 hr
Excretion: urine (38% as unchanged drug); high urinary levels (100 mcg/mL) persist for >48 hr
Mechanism of Action
Blocks bacterial cell wall synthesis by inactivating enolpyruvyl transferase; also reduces bacterial adherence to uroepithelial cells
Images
Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
