Dosing & Uses
Dosage Forms & Strengths
powder for reconstitution
- 3g/packet
Urinary Tract Infection (Acute Cystitis)
Acute cystitis caused by E. coli, E. faecalis
Women >18 years: 3 g PO once
Males >18 years: 3 g every 2-3 days for 3 doses
Preparation: Dissolve 1 packet (3 g) in 3-4 oz water
Prostatitis
3 g PO every 3 days for 21 days
Safety & efficacy not established
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Adverse Effects
1-10%
Anorexia
Diarrhea
Epigastric
Discomfort
Headache
Nausea
Rash
Vomiting
<1%
Dizziness
Drowsiness
Fatigue
Pruritus
Warnings
Contraindications
Hypersensitivity
Pregnancy & Lactation
Pregnancy Category: B
Lactation: excreted in breast milk; not recommended
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Absorption: well absorbed
Distribution: Vd: 2 L/kg; high concentrations in urine; well into other tissues; crosses maximally into CSF with inflamed meninges
Protein binding: < 3%
Bioavailability: 34-58%
Half-life Elimination
Normal renal function: 4-8 hr
CrCl <10 mL/min: 50 hr
Other Information
Time to peak, serum: 2 hr
Excretion: urine (38% as unchanged drug); high urinary levels (100 mcg/mL) persist for >48 hr
Mechanism of Action
Blocks bacterial cell wall synthesis by inactivating enolpyruvyl transferase; also reduces bacterial adherence to uroepithelial cells
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Patient Handout
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
