nystatin (Rx)

Brand and Other Names:Mycostatin, Nilstat, more...Nyamyc, Nystat Rx, Nystatin Systemic, Nystex
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral powder

  • 100,000units/g

oral suspension

  • 100,000units/mL

oral tablet

  • 500,000units

capsule

  • 500,000units
  • 1,000,000units

Oropharyngeal Candidiasis

Oral suspension: 400,000-600,000 units PO q6hr; swish in mouth several minutes and then swallow

Intestinal Candidiasis

Oral tablets: 500,000-1,000,000 units q8hr

Powder: 1/8 to 1/4 teaspoonful in 1/2 cup of water (500,000-1,000,000 units) PO q8hr

Invasive Fungal Infections (Orphan)

Liposomal nystatin: Treatment of invasive fungal infections

Orphan indication sponsor

  • The University of Texas, M.D. Anderson Cancer Center, Unit 038; Houston, TX 77030

Administration

Retain suspension in mouth as long as possible before swallowing

Dosage Forms & Strengths

oral powder

  • 100,000units/g

oral suspension

  • 100,000units/mL

oral tablet

  • 500,000units

capsule

  • 500,000units
  • 1,000,000units

Oropharyngeal Candidiasis

Premature infants

  • 100,000 units PO q6hr; paint suspension into recesses of the mouth

Infants

  • 200,000 units PO q6hr (100,000 units in each side of mouth); paint suspension into recesses of the mouth

Children

  • Oral suspension: 400,000-600,000 units PO q6hr; swish in mouth several minutes and then swallow

Intestinal Candidiasis

Oral tablets: 500,000 units-1,000,000 units q8hr

Powder: 1/8 to 1/4 teaspoonful in 1/2 cup of water (500,000-1,000,000 units) PO q8hr

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Interactions

Interaction Checker

and nystatin

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (1)

            • allogeneic cultured keratinocytes/fibroblasts in bovine collagen

              nystatin decreases effects of allogeneic cultured keratinocytes/fibroblasts in bovine collagen by Other (see comment). Contraindicated. Comment: Exposure to topical antibiotics has been shown to degrade Gintuit; if exposed, irrigate the wound thoroughly with saline and allow a suitable wash-out period to elapse before applying Gintuit.

            Serious - Use Alternative (1)

            • Saccharomyces boulardii

              nystatin decreases effects of Saccharomyces boulardii by unspecified interaction mechanism. Avoid or Use Alternate Drug. Systemic or oral antifungals may decrease activity of probiotic.

            Monitor Closely (1)

            • voclosporin

              voclosporin, nystatin. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.

            Minor (0)

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              Adverse Effects

              Frequency not defined

              Diarrhea

              Nausea

              Stomach pain

              Vomiting

              Contact dermatitis

              Stevens-Johnson syndrome

              Hypersensitivity reactions

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              Warnings

              Contraindications

              Hypersensitivity

              Cautions

              Not for use in systemic mycoses

              Discontinue therapy if irritation or sensitization observed during use

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              Pregnancy & Lactation

              Pregnancy category: C

              Lactation: Not known if excreted in breast milk; use caution

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

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              Pharmacology

              Mechanism of Action

              Binds sterols in fungal cell membrane, altering permeability and thus causing cellular contents to leak

              Absorption

              Poor PO absorption

              Onset: Symptom relief for oral candidiasis 24-72 hr

              Elimination

              Excretion: Feces (as unchanged drug)

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              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin oral
              -
              500,000 unit tablet
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin oral
              -
              500,000 unit tablet
              nystatin oral
              -
              500,000 unit tablet
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin oral
              -
              100,000 unit/mL suspension
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
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              100,000 unit/gram powder
              nystatin topical
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              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
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              100,000 unit/gram powder
              nystatin topical
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              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
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              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram cream
              nystatin topical
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              100,000 unit/gram cream
              nystatin topical
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              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram powder
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram ointment
              nystatin topical
              -
              100,000 unit/gram cream
              nystatin topical
              -
              100,000 unit/gram ointment
              Nyamyc topical
              -
              100,000 unit/gram powder
              Nyamyc topical
              -
              100,000 unit/gram powder
              Nyamyc topical
              -
              100,000 unit/gram powder
              Nystop topical
              -
              100,000 unit/gram powder
              Nystop topical
              -
              100,000 unit/gram powder
              Nystop topical
              -
              100,000 unit/gram powder

              Copyright © 2010 First DataBank, Inc.

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              Patient Handout

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              Patient Education
              nystatin oral

              NYSTATIN TABLET - ORAL

              (NYE-stat-in)

              COMMON BRAND NAME(S): Mycostatin

              USES: This medication is used to treat fungal infections in the stomach or intestines. Nystatin is an antifungal that works by stopping the growth of fungus.Nystatin tablets should not be used to treat fungal infections of the blood.

              HOW TO USE: Take this medication by mouth 3 times a day or as directed by your doctor. It may take from several days to several months to complete treatment. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day. Dosage is based on your medical condition and response to therapy.Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow the infection to continue, resulting in a return of the infection.Tell your doctor if your condition lasts after several days of treatment or gets worse at any time.

              SIDE EFFECTS: Diarrhea, nausea, vomiting, or stomach upset may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including fast heartbeat, shortness of breath, muscle pain.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: Before taking nystatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: HIV disease, diabetes, kidney disease.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

              NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

              MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

              STORAGE: Store at room temperature away from heat and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

              Information last revised April 2022. Copyright(c) 2022 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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              Formulary

              FormularyPatient Discounts

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              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
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              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
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              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
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              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
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              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.