nystatin (Rx)

Brand and Other Names:Mycostatin, Nilstat, more...Nyamyc, Nystat Rx, Nystatin Systemic, Nystex
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral powder

  • 100,000units/g

oral suspension

  • 100,000units/mL

oral tablet

  • 500,000units

capsule

  • 500,000units
  • 1,000,000units

Oropharyngeal Candidiasis

Oral suspension: 400,000-600,000 units PO q6hr; swish in mouth several minutes and then swallow

Intestinal Candidiasis

Oral tablets: 500,000-1,000,000 units q8hr

Powder: 1/8 to 1/4 teaspoonful in 1/2 cup of water (500,000-1,000,000 units) PO q8hr

Invasive Fungal Infections (Orphan)

Liposomal nystatin: Treatment of invasive fungal infections

Orphan indication sponsor

  • The University of Texas, M.D. Anderson Cancer Center, Unit 038; Houston, TX 77030

Administration

Retain suspension in mouth as long as possible before swallowing

Dosage Forms & Strengths

oral powder

  • 100,000units/g

oral suspension

  • 100,000units/mL

oral tablet

  • 500,000units

capsule

  • 500,000units
  • 1,000,000units

Oropharyngeal Candidiasis

Premature infants

  • 100,000 units PO q6hr; paint suspension into recesses of the mouth

Infants

  • 200,000 units PO q6hr (100,000 units in each side of mouth); paint suspension into recesses of the mouth

Children

  • Oral suspension: 400,000-600,000 units PO q6hr; swish in mouth several minutes and then swallow

Intestinal Candidiasis

Oral tablets: 500,000 units-1,000,000 units q8hr

Powder: 1/8 to 1/4 teaspoonful in 1/2 cup of water (500,000-1,000,000 units) PO q8hr

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Interactions

Interaction Checker

and nystatin

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (1)

            • allogeneic cultured keratinocytes/fibroblasts in bovine collagen

              nystatin decreases effects of allogeneic cultured keratinocytes/fibroblasts in bovine collagen by Other (see comment). Contraindicated. Comment: Exposure to topical antibiotics has been shown to degrade Gintuit; if exposed, irrigate the wound thoroughly with saline and allow a suitable wash-out period to elapse before applying Gintuit.

            Serious - Use Alternative (1)

            • Saccharomyces boulardii

              nystatin decreases effects of Saccharomyces boulardii by unspecified interaction mechanism. Avoid or Use Alternate Drug. Systemic or oral antifungals may decrease activity of probiotic.

            Monitor Closely (0)

              Minor (0)

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                Adverse Effects

                Frequency not defined

                Diarrhea

                Nausea

                Stomach pain

                Vomiting

                Contact dermatitis

                Stevens-Johnson syndrome

                Hypersensitivity reactions

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                Warnings

                Contraindications

                Hypersensitivity

                Cautions

                Not for use in systemic mycoses

                Discontinue therapy if irritation or sensitization observed during use

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                Pregnancy & Lactation

                Pregnancy category: C

                Lactation: Not known if excreted in breast milk; use caution

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Binds sterols in fungal cell membrane, altering permeability and thus causing cellular contents to leak

                Absorption

                Poor PO absorption

                Onset: Symptom relief for oral candidiasis 24-72 hr

                Elimination

                Excretion: Feces (as unchanged drug)

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                Images

                BRAND FORM. UNIT PRICE PILL IMAGE
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram ointment
                nystatin topical
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                100,000 unit/gram ointment
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
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                100,000 unit/gram powder
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
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                100,000 unit/gram cream
                nystatin topical
                -
                100,000 unit/gram ointment
                nystatin topical
                -
                100,000 unit/gram ointment
                nystatin topical
                -
                100,000 unit/gram ointment
                nystatin topical
                -
                100,000 unit/gram cream
                nystatin topical
                -
                100,000 unit/gram ointment
                nystatin topical
                -
                100,000 unit/gram cream
                nystatin topical
                -
                100,000 unit/gram ointment
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram ointment
                nystatin topical
                -
                100,000 unit/gram ointment
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram cream
                nystatin topical
                -
                100,000 unit/gram ointment
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram powder
                nystatin topical
                -
                100,000 unit/gram cream
                nystatin oral
                -
                500,000 unit tablet
                nystatin oral
                -
                500,000 unit tablet
                nystatin oral
                -
                100,000 unit/mL suspension
                nystatin oral
                -
                100,000 unit/mL suspension
                nystatin oral
                -
                500,000 unit tablet
                nystatin oral
                -
                100,000 unit/mL suspension
                nystatin oral
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                100,000 unit/mL suspension
                nystatin oral
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                100,000 unit/mL suspension
                nystatin oral
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                100,000 unit/mL suspension
                nystatin oral
                -
                100,000 unit/mL suspension
                nystatin oral
                -
                100,000 unit/mL suspension
                nystatin oral
                -
                100,000 unit/mL suspension
                Nyamyc topical
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                100,000 unit/gram powder
                Nyamyc topical
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                100,000 unit/gram powder
                Nyamyc topical
                -
                100,000 unit/gram powder
                Nystop topical
                -
                100,000 unit/gram powder
                Nystop topical
                -
                100,000 unit/gram powder
                Nystop topical
                -
                100,000 unit/gram powder

                Copyright © 2010 First DataBank, Inc.

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                Patient Handout

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                Patient Education
                nystatin topical

                NYSTATIN POWDER - TOPICAL

                (NYE-stat-in)

                COMMON BRAND NAME(S): Nystop, Pedi-dri

                USES: Nystatin is used to treat fungal skin infections. Nystatin is an antifungal that works by stopping the growth of fungus.

                HOW TO USE: Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply this medication to the affected skin, usually twice a day or as directed by your doctor. Dosage and length of treatment depends on the type of infection being treated. Do not apply this more often than prescribed.Apply enough powder to lightly coat the affected area and some of the surrounding skin. After applying this medication, wash your hands unless you are using this medication to treat the hands. Do not wrap, cover or bandage the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.Do not apply this medication in the eyes, nose, mouth, or vagina.Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after starting nystatin. Stopping the medication too early may allow the fungus to continue to grow, which may result in a return of the infection.Inform your doctor if your condition persists after 2 weeks of treatment or worsens at any time.

                SIDE EFFECTS: Skin irritation or redness may occur. If either of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                PRECAUTIONS: Before using nystatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

                DRUG INTERACTIONS: Your healthcare professionals (such as your doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

                OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms that may occur after swallowing include: nausea, vomiting or stomach upset.

                NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

                MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

                STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                Information last revised April 2019. Copyright(c) 2021 First Databank, Inc.

                IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                Formulary

                FormularyPatient Discounts

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                The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                Tier Description
                1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                NC NOT COVERED – Drugs that are not covered by the plan.
                Code Definition
                PA Prior Authorization
                Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                QL Quantity Limits
                Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
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                Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.