Suggested Dosing
Benzodiazepine Withdrawal in Elderly with Insomnia
2 mg controlled-release PO qHS for up to 6 months; taper dose over 6 weeks
Cancer, Adjunctive Therapy
10-50 mg PO daily
Cluster Headache, Prevention
10 mg PO qHS
Migraine Headache
3 mg PO HS
Insomnia
3-5 mg PO qHS
Difficulty falling asleep
- 5 mg PO 3-4 hour before sleep period x 4 weeks
Difficulty maintaining sleep
- Use controlled release formulation
Thrombocytopenia, Chemo-related
20 mg PO qHS
Jet Lag
0.5-5 mg PO HS
Eastbound
- Preflight, early evening dose followed by HS dosing x 4days
Westbound
- Treat HS x 4days when in new time zone
Chronic Fatique Syndrome
5 mg PO HS
Nicotine Withdrawal
0.3 mg PO 3.5 hours after stopping smoking
Winter Depression
0.125 mg PO twice daily
Premedication for Surgery
0.5 mg/kg SL
Tardive Dyskinesia
10 mg controlled-release PO qDay
Sleep Disorders (Orphan)
Orphan designation for treatment of circadian rhythm sleep disorders in blind people without light perception
Orphan sponsors
- Neurim Pharmaceuticals, Ltd; 8 Hanechoshet St; Tel-Aviv, Israel
- Sack, Robert, M.D.; Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road; Portland, OR 97201
Encephalopathy (Orphan)
Orphan designation for treatment of neonatal hypoxic ischemic encephalopathy
Orphan sponsor
- Scharper S.p.A.; Viale Ortles 12; Milan 20139, Italy
Smith-Magenis Syndrome (Orphan)
Orphan designation for treatment of Smith-Magenis syndrome in combination with a beta-blocker
Orphan sponsor
- Therapicon SrL; 21 Via Malachia Marchesi de Taddei; Milano, Italy
Acetaminophen Overdose (Orphan)
Orphan designation for treatment of acute acetaminophen overdose
Orphan sponsor
- Therapicon SrL; 21 Via Malachia Marchesi de Taddei; Milano, Italy
Short Bowel Syndrome (Orphan)
Orphan designation for treatment of short bowel syndrome
Orphan sponsor
- Therapicon SrL; 21 Via Malachia Marchesi de Taddei; Milano, Italy
Necrotizing Enterocolitis (Orphan)
Orphan designation for treatment of necrotizing enterocolitis
Orphan sponsor
- Therapicon SrL; 21 Via Malachia Marchesi de Taddei; Milano, Italy
Acute Radiation Syndrome (Orphan)
Orphan designation for treatment of acute radiation syndrome
Orphan sponsor
- WORPHMED Srl; Via Malachia Marchesi de Taddei, 21; Milan, Italy
Hepatocellular Carcinoma (Orphan)
Orphan designation for treatment of hepatocellular carcinoma
Orphan sponsor
- Worphmed Srl; Via Malachia Marchesi de Taddei, 21; Milan, Italy
Heat Stroke (Orphan)
Orphan designation for treatment of heat stroke
Orphan sponsor
- Worphmed Srl; Via Malachia Marchesi de Taddei, 21; Milan, Italy
Pancreatic Cancer (Orphan)
Orphan designation for treatment of pancreatic cancer
Sponsor
- WORPHMED Srl; Via Malachia Marchesi de Taddei, 21; Milan, Italy
Suggested Uses
Alzheimer's disease, benzodiazepine or nicotine withdrawal, cancer (adjunctive treatment), headache (prevention), insomnia, jet lag, shift-work disorder, sleep disorders, thrombocytopenia (chemo-induced), winter depression, tardive dyskinesia
Efficacy
Circadian rhythm sleep disorders: FDA orphan drug status
Insomnia: Helpful for sleep-wake cycle disorders
Research is continuing
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (10)
- calcium/magnesium/potassium/sodium oxybates
melatonin, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- fexinidazole
fexinidazole will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of melatonin with strong CYP1A2 inhibitors
- fluvoxamine
fluvoxamine will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of melatonin with strong CYP1A2 inhibitors
- methoxsalen
methoxsalen will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of melatonin with strong CYP1A2 inhibitors
- mexiletine
mexiletine will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of melatonin with strong CYP1A2 inhibitors
- propofol
melatonin and propofol both increase sedation. Avoid or Use Alternate Drug.
- rucaparib
rucaparib will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of melatonin with strong CYP1A2 inhibitors
- sodium oxybate
melatonin, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- viloxazine
viloxazine will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of melatonin with strong CYP1A2 inhibitors
- zileuton
zileuton will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of melatonin with strong CYP1A2 inhibitors
Monitor Closely (222)
- abciximab
melatonin increases effects of abciximab by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- albuterol
melatonin increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
alfentanil and melatonin both increase sedation. Use Caution/Monitor.
- alprazolam
alprazolam and melatonin both increase sedation. Use Caution/Monitor.
- alteplase
melatonin increases effects of alteplase by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- amitriptyline
amitriptyline and melatonin both increase sedation. Use Caution/Monitor.
- amlodipine
melatonin decreases effects of amlodipine by pharmacodynamic antagonism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- amobarbital
amobarbital and melatonin both increase sedation. Use Caution/Monitor.
- amoxapine
amoxapine and melatonin both increase sedation. Use Caution/Monitor.
- anagrelide
melatonin increases effects of anagrelide by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- antithrombin III
melatonin increases effects of antithrombin III by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- apixaban
melatonin increases effects of apixaban by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- apomorphine
apomorphine and melatonin both increase sedation. Use Caution/Monitor.
- arformoterol
melatonin increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- argatroban
melatonin increases effects of argatroban by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- aripiprazole
aripiprazole and melatonin both increase sedation. Use Caution/Monitor.
- armodafinil
melatonin increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aspirin
melatonin increases effects of aspirin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- azelastine
azelastine and melatonin both increase sedation. Use Caution/Monitor.
- baclofen
baclofen and melatonin both increase sedation. Use Caution/Monitor.
- belladonna and opium
belladonna and opium and melatonin both increase sedation. Use Caution/Monitor.
- benperidol
benperidol and melatonin both increase sedation. Use Caution/Monitor.
- benzphetamine
melatonin increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- bivalirudin
melatonin increases effects of bivalirudin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- brompheniramine
brompheniramine and melatonin both increase sedation. Use Caution/Monitor.
- buprenorphine
buprenorphine and melatonin both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
buprenorphine buccal and melatonin both increase sedation. Use Caution/Monitor.
- butabarbital
butabarbital and melatonin both increase sedation. Use Caution/Monitor.
- butalbital
butalbital and melatonin both increase sedation. Use Caution/Monitor.
- butorphanol
butorphanol and melatonin both increase sedation. Use Caution/Monitor.
- caffeine
melatonin increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- capmatinib
capmatinib will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Monitor melatonin effects if coadministered with moderate CYP1A2 inhibitors
- carbinoxamine
carbinoxamine and melatonin both increase sedation. Use Caution/Monitor.
- carisoprodol
carisoprodol and melatonin both increase sedation. Use Caution/Monitor.
- chloral hydrate
chloral hydrate and melatonin both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
chlordiazepoxide and melatonin both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and melatonin both increase sedation. Use Caution/Monitor.
- chlorpromazine
chlorpromazine and melatonin both increase sedation. Use Caution/Monitor.
- chlorzoxazone
chlorzoxazone and melatonin both increase sedation. Use Caution/Monitor.
- cigarette smoking
cigarette smoking will decrease the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.
- cilostazol
melatonin increases effects of cilostazol by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- cimetidine
cimetidine will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Monitor melatonin effects if coadministered with moderate CYP1A2 inhibitors
- cinnarizine
cinnarizine and melatonin both increase sedation. Use Caution/Monitor.
- ciprofloxacin
ciprofloxacin will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Monitor melatonin effects if coadministered with moderate CYP1A2 inhibitors
- clemastine
clemastine and melatonin both increase sedation. Use Caution/Monitor.
- clevidipine
melatonin decreases effects of clevidipine by pharmacodynamic antagonism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- clomipramine
clomipramine and melatonin both increase sedation. Use Caution/Monitor.
- clonazepam
clonazepam and melatonin both increase sedation. Use Caution/Monitor.
- clopidogrel
melatonin increases effects of clopidogrel by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- clorazepate
clorazepate and melatonin both increase sedation. Use Caution/Monitor.
- clozapine
clozapine and melatonin both increase sedation. Use Caution/Monitor.
- codeine
codeine and melatonin both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and melatonin both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
cyclobenzaprine and melatonin both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and melatonin both increase sedation. Use Caution/Monitor.
- dabigatran
melatonin increases effects of dabigatran by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- dalteparin
melatonin increases effects of dalteparin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- dantrolene
dantrolene and melatonin both increase sedation. Use Caution/Monitor.
- desipramine
desipramine and melatonin both increase sedation. Use Caution/Monitor.
- desirudin
melatonin increases effects of desirudin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- dexchlorpheniramine
dexchlorpheniramine and melatonin both increase sedation. Use Caution/Monitor.
- dexfenfluramine
melatonin increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
dexmedetomidine and melatonin both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
melatonin increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
melatonin increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
dextromoramide and melatonin both increase sedation. Use Caution/Monitor.
- diamorphine
diamorphine and melatonin both increase sedation. Use Caution/Monitor.
- diazepam
diazepam and melatonin both increase sedation. Use Caution/Monitor.
- diclofenac
melatonin increases effects of diclofenac by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- diethylpropion
melatonin increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difenoxin hcl
difenoxin hcl and melatonin both increase sedation. Use Caution/Monitor.
- diflunisal
melatonin increases effects of diflunisal by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- dimenhydrinate
dimenhydrinate and melatonin both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and melatonin both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
diphenoxylate hcl and melatonin both increase sedation. Use Caution/Monitor.
- dipipanone
dipipanone and melatonin both increase sedation. Use Caution/Monitor.
- dipyridamole
melatonin increases effects of dipyridamole by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- dobutamine
melatonin increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopamine
melatonin increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
melatonin increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- doxepin
doxepin and melatonin both increase sedation. Use Caution/Monitor.
- doxylamine
doxylamine and melatonin both increase sedation. Use Caution/Monitor.
- droperidol
droperidol and melatonin both increase sedation. Use Caution/Monitor.
- enoxaparin
melatonin increases effects of enoxaparin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- ephedrine
melatonin increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
melatonin increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
melatonin increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- eptifibatide
melatonin increases effects of eptifibatide by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- estazolam
estazolam and melatonin both increase sedation. Use Caution/Monitor.
- ethanol
ethanol and melatonin both increase sedation. Use Caution/Monitor.
- etodolac
melatonin increases effects of etodolac by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- felodipine
melatonin decreases effects of felodipine by pharmacodynamic antagonism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers vMelatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- fenfluramine
melatonin increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fenoprofen
melatonin increases effects of fenoprofen by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- fluoxetine
fluoxetine will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Monitor melatonin effects if coadministered with moderate CYP1A2 inhibitors
- fluphenazine
fluphenazine and melatonin both increase sedation. Use Caution/Monitor.
- flurazepam
flurazepam and melatonin both increase sedation. Use Caution/Monitor.
- flurbiprofen
melatonin increases effects of flurbiprofen by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- fondaparinux
melatonin increases effects of fondaparinux by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- formoterol
melatonin increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- givosiran
givosiran will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Monitor melatonin effects if coadministered with moderate CYP1A2 inhibitors
- haloperidol
haloperidol and melatonin both increase sedation. Use Caution/Monitor.
- heparin
melatonin increases effects of heparin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- hydromorphone
hydromorphone and melatonin both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and melatonin both increase sedation. Use Caution/Monitor.
- ibuprofen
melatonin increases effects of ibuprofen by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- ibuprofen IV
melatonin increases effects of ibuprofen IV by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- iloperidone
iloperidone and melatonin both increase sedation. Use Caution/Monitor.
- imipramine
imipramine and melatonin both increase sedation. Use Caution/Monitor.
- indomethacin
melatonin increases effects of indomethacin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- isoproterenol
melatonin increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- isradipine
melatonin decreases effects of isradipine by pharmacodynamic antagonism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- ketamine
ketamine and melatonin both increase sedation. Use Caution/Monitor.
- ketoprofen
melatonin increases effects of ketoprofen by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- ketorolac
melatonin increases effects of ketorolac by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- ketotifen, ophthalmic
ketotifen, ophthalmic and melatonin both increase sedation. Use Caution/Monitor.
- leniolisib
leniolisib will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Monitor melatonin effects if coadministered with moderate CYP1A2 inhibitors
- levalbuterol
melatonin increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levamlodipine
melatonin decreases effects of levamlodipine by pharmacodynamic antagonism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- levorphanol
levorphanol and melatonin both increase sedation. Use Caution/Monitor.
- lisdexamfetamine
melatonin increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
lofepramine and melatonin both increase sedation. Use Caution/Monitor.
- lofexidine
lofexidine and melatonin both increase sedation. Use Caution/Monitor.
- loprazolam
loprazolam and melatonin both increase sedation. Use Caution/Monitor.
- lorazepam
lorazepam and melatonin both increase sedation. Use Caution/Monitor.
- lormetazepam
lormetazepam and melatonin both increase sedation. Use Caution/Monitor.
- loxapine
loxapine and melatonin both increase sedation. Use Caution/Monitor.
- loxapine inhaled
loxapine inhaled and melatonin both increase sedation. Use Caution/Monitor.
- maprotiline
maprotiline and melatonin both increase sedation. Use Caution/Monitor.
- marijuana
marijuana and melatonin both increase sedation. Use Caution/Monitor.
- meclofenamate
melatonin increases effects of meclofenamate by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- mefenamic acid
melatonin increases effects of mefenamic acid by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- meperidine
meperidine and melatonin both increase sedation. Use Caution/Monitor.
- meprobamate
melatonin and meprobamate both increase sedation. Use Caution/Monitor.
- metaproterenol
melatonin increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
metaxalone and melatonin both increase sedation. Use Caution/Monitor.
- methadone
methadone and melatonin both increase sedation. Use Caution/Monitor.
- methamphetamine
melatonin increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
methocarbamol and melatonin both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
melatonin increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
midazolam and melatonin both increase sedation. Use Caution/Monitor.
- midodrine
melatonin increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
melatonin and mirtazapine both increase sedation. Use Caution/Monitor.
- modafinil
melatonin increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
morphine and melatonin both increase sedation. Use Caution/Monitor.
- motherwort
melatonin and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
melatonin and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
melatonin and nabilone both increase sedation. Use Caution/Monitor.
- nabumetone
melatonin increases effects of nabumetone by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- nalbuphine
nalbuphine and melatonin both increase sedation. Use Caution/Monitor.
- naproxen
melatonin increases effects of naproxen by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- nicardipine
melatonin decreases effects of nicardipine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- nifedipine
melatonin decreases effects of nifedipine by pharmacodynamic antagonism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- nimodipine
melatonin decreases effects of nimodipine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- nisoldipine
melatonin decreases effects of nisoldipine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Melatonin may diminish the antihypertensive effect of dihydropyridine calcium channel blockers .
- norepinephrine
melatonin increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
nortriptyline and melatonin both increase sedation. Use Caution/Monitor.
- olanzapine
olanzapine and melatonin both increase sedation. Use Caution/Monitor.
- opium tincture
opium tincture and melatonin both increase sedation. Use Caution/Monitor.
- orphenadrine
orphenadrine and melatonin both increase sedation. Use Caution/Monitor.
- oxaprozin
melatonin increases effects of oxaprozin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- oxazepam
oxazepam and melatonin both increase sedation. Use Caution/Monitor.
- oxycodone
oxycodone and melatonin both increase sedation. Use Caution/Monitor.
- oxymorphone
oxymorphone and melatonin both increase sedation. Use Caution/Monitor.
- paliperidone
paliperidone and melatonin both increase sedation. Use Caution/Monitor.
- papaveretum
papaveretum and melatonin both increase sedation. Use Caution/Monitor.
- pentazocine
pentazocine and melatonin both increase sedation. Use Caution/Monitor.
- pentobarbital
pentobarbital and melatonin both increase sedation. Use Caution/Monitor.
- perphenazine
perphenazine and melatonin both increase sedation. Use Caution/Monitor.
- phendimetrazine
melatonin increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenobarbital
phenobarbital and melatonin both increase sedation. Use Caution/Monitor.
phenobarbital will decrease the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. - phentermine
melatonin increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
melatonin increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
melatonin increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
melatonin and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
pimozide and melatonin both increase sedation. Use Caution/Monitor.
- pirbuterol
melatonin increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- piroxicam
melatonin increases effects of piroxicam by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- prasugrel
melatonin increases effects of prasugrel by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- primidone
primidone and melatonin both increase sedation. Use Caution/Monitor.
primidone will decrease the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. - prochlorperazine
prochlorperazine and melatonin both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and melatonin both increase sedation. Use Caution/Monitor.
- propylhexedrine
melatonin increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protein C concentrate
melatonin increases effects of protein C concentrate by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- protriptyline
protriptyline and melatonin both increase sedation. Use Caution/Monitor.
- quazepam
quazepam and melatonin both increase sedation. Use Caution/Monitor.
- quetiapine
quetiapine and melatonin both increase sedation. Use Caution/Monitor.
- ramelteon
melatonin and ramelteon both increase sedation. Use Caution/Monitor.
- reteplase
melatonin increases effects of reteplase by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- rifampin
rifampin will decrease the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor.
- risperidone
risperidone and melatonin both increase sedation. Use Caution/Monitor.
- ritlecitinib
ritlecitinib will increase the level or effect of melatonin by additive vasodilation. Use Caution/Monitor. Monitor melatonin effects if coadministered with moderate CYP1A2 inhibitors
- rivaroxaban
melatonin increases effects of rivaroxaban by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- salmeterol
melatonin increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
melatonin and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
secobarbital and melatonin both increase sedation. Use Caution/Monitor.
- shepherd's purse
melatonin and shepherd's purse both increase sedation. Use Caution/Monitor.
- stiripentol
stiripentol, melatonin. affecting hepatic enzyme CYP1A2 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP1A2 inhibitor and inducer. Monitor CYP1A2 substrates coadministered with stiripentol for increased or decreased effects. CYP1A2 substrates may require dosage adjustment.
- sufentanil
sufentanil and melatonin both increase sedation. Use Caution/Monitor.
- sulindac
melatonin increases effects of sulindac by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- tapentadol
tapentadol and melatonin both increase sedation. Use Caution/Monitor.
- temazepam
temazepam and melatonin both increase sedation. Use Caution/Monitor.
- tenecteplase
melatonin increases effects of tenecteplase by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- terbutaline
melatonin increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
thioridazine and melatonin both increase sedation. Use Caution/Monitor.
- thiothixene
thiothixene and melatonin both increase sedation. Use Caution/Monitor.
- ticlopidine
melatonin increases effects of ticlopidine by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- tirofiban
melatonin increases effects of tirofiban by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- tolmetin
melatonin increases effects of tolmetin by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
- topiramate
melatonin and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
tramadol and melatonin both increase sedation. Use Caution/Monitor.
- trazodone
trazodone and melatonin both increase sedation. Use Caution/Monitor.
- triazolam
triazolam and melatonin both increase sedation. Use Caution/Monitor.
- triclofos
triclofos and melatonin both increase sedation. Use Caution/Monitor.
- trifluoperazine
trifluoperazine and melatonin both increase sedation. Use Caution/Monitor.
- trimipramine
trimipramine and melatonin both increase sedation. Use Caution/Monitor.
- triprolidine
triprolidine and melatonin both increase sedation. Use Caution/Monitor.
- vemurafenib
vemurafenib will increase the level or effect of melatonin by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Monitor melatonin effects if coadministered with moderate CYP1A2 inhibitors
- xylometazoline
melatonin increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
melatonin increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
melatonin and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
ziprasidone and melatonin both increase sedation. Use Caution/Monitor.
Minor (2)
- eucalyptus
eucalyptus and melatonin both increase sedation. Minor/Significance Unknown.
- sage
melatonin and sage both increase sedation. Minor/Significance Unknown.
Adverse Effects
Frequency Not Defined
Abdominal cramps
Alertness decreased
Circadian rhythm disruption
Daytime fatigue
Depression (transient)
Dizziness
Drowsiness
Dysphoria in depressed patients
Headache
Irritability
Warnings
Contraindications
Concurrent immunosuppressive treatment
Cautions
Age <20 years old, depression, hypertension, impaired liver function, seizure disorder
Pregnancy & Lactation
Pregnancy: avoid use
Lactation: avoid use
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Hormone produced by pineal gland; regulates sleep cycle
Pharmacokinetics
Not studied