mometasone, intranasal (Rx)

Brand and Other Names:Nasonex
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

nasal spray suspension

  • 50mcg/spray

Allergic Rhinitis

Nasal symptoms of allergic rhinitis

2 sprays (100 mcg) in each nostril qDay

Seasonal Allergic Rhinitis

Nasal congestion associated with seasonal allergic rhinitis; also indicated for prophylaxis of seasonal allergic rhinitis

Treatment: 2 sprays (100 mcg) in each nostril qDay

Prophylaxis: 2 sprays (100 mcg) in each nostril qDay; initiate 2-4 weeks prior to pollen season

Nasal Polyps

2 sprays (100 mcg) in each nostril q12hr; qDay dosing may be effective in some patients

Dosage Forms & Strengths

nasal spray suspension

  • 50mcg/spray

Allergic Rhinitis

Nasal symptoms of allergic rhinitis

<2 years: Safety and efficacy not established

2-12 years: 1 spray (50 mcg) in each nostril qDay

≥12 years: 2 sprays (100 mcg) in each nostril qDay

Seasonal Allergic Rhinitis

Nasal congestion associated with seasonal allergic rhinitis; also indicated for prophylaxis of seasonal allergic rhinitis

Treatment

  • <2 years: Safety and efficacy not established
  • 2-12 years: 1 spray (50 mcg) in each nostril qDay
  • >12 years: 2 sprays (100 mcg) in each nostril qDay

Prophylaxis

  • <12 years: Safety and efficacy not established
  • >12 years: 2 sprays (100 mcg) in each nostril qDay; initiate 2-4 weeks prior to allergy season

Nasal Polyps

Safety and efficacy not established

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Interactions

Interaction Checker

and mometasone, intranasal

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Headache

            Pharyngitis

            Cough

            Viral infection

            Epistaxis

            1-10%

            Diarrhea

            Dyspnea

            Vomiting

            Dysmenorrhea

            Musculoskeletal pain

            Myalgia

            Conjunctivitis

            Otitis media

            Flu-like syndrome

            <1%

            Anaphylaxis

            Angioedema

            Growth suppression

            Nasal candidiasis

            Taste disturbance

            Nasal septal perforation

            Nasal burning and irritation

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            Warnings

            Contraindications

            Hypersensitivity

            Recent nasal surgery, nasal trauma, nasal septum ulcers (until healing has occurred)

            Cautions

            Monitor for vision change or, with history of increased IOP, glaucoma, or for cataracts; consider referral to an ophthalmologist in patients who develop ocular symptoms or use therapy long term

            Respiratory tract fungal or bacterial infections, viral/parasitic infections, or ocular herpes simplex may occur

            Potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infections; or ocular herpes simplex

            More serious or fatal course of chickenpox or measles in susceptible patients

            Risk for hypercorticism and adrenal suppression with higher-than-normal doses

            Potential reduction of growth velocity in children

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            Pregnancy & Lactation

            Pregnancy category: C

            Lactation: Unknown whether distributed in breast milk

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Corticosteroid with potent anti-inflammatory properties; elicits effects on various cells, including mast cells and eosinophils; also elicits effects on inflammatory mediators (eg, histamine, eicosanoids, leukotrienes, cytokines)

            Absorption

            Bioavailability: <1%

            Minimal systemic absorption occurs, mostly by small amount swallowed during nasal administration

            Distribution

            Protein bound: 98-99%

            Metabolism

            Metabolism: CYP3A4

            Elimination

            Half-life: 5.8 hr

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.