Dosing & Uses
Hyperoxaluria
Pending FDA approval for primary hyperoxaluria
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Pharmacology
Mechanism of Action
Reduces levels of glycolate oxidase (GO) enzyme by targeting the hydroxyacid oxidase 1 mRNA in hepatocytes through RNA interference
Decreased GO enzyme levels reduce the amount of available glyoxylate, a substrate for oxalate production that increases the risk of kidney stones
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Images
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
