hydrocortisone-ophthalmic dosing, indications, interactions, adverse effects, and more

Sections

Sections neomycin/polymyxin B/hydrocortisone/bacitracin ophthalmic
Dosing & Uses
Adverse Effects
Warnings
Pregnancy
Pharmacology
Images
Patient Handout
Formulary

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

bacitracin ophthalmic/neomycin/polymyxin B/hydrocortisone

ophthalmic ointment

400units/0.35%/10,000units/1%

Ocular Inflammation/Infection

Apply thin ribbon of ointment to conjunctival sac of affected eye(s) q3-4hr, depending on severity

Safety and efficacy not established

Frequency Not Defined

Allergies

Glaucoma

Rash

Superinfection (herpes)

Contraindications

Hypersensivity to neomycin

Glaucoma

Viral diseases of cornea and conjunctiva (epithelial herpes simplex keratitis, vaccinia, varicella)

Mycobacterial infection of eye & fungal diseases of ocular structures

Cautions

Not used much, because of hypersensitivity reactions to neomycin; also, because of steroid component, adequate follow up is essential

Prolonged use or misuse of ocular corticosteroid may result in glaucoma, superinfection (herpes) etc

Newer agents have better steroid & antibiotic coverage

Pregnancy & Lactation

Pregnancy Category: C

Lacation: Unknown

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Bacitracin: Inhibits bacterial cell wall synthesis by preventing the incorporation of amino acids and nucleotides into the cell wall

Neomycin: Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits

Polymyxin B: Bactericidal; causes leakage of bacterial membrane

Hydrocortisone: Decrease inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes

Images

No images available for this drug.

Patient Handout

A Patient Handout is not currently available for this monograph.

Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

View explanations for tiers and restrictions

Tier	Description
1	This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2	This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6	This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC	NOT COVERED – Drugs that are not covered by the plan.

Code	Definition
PA	Prior Authorization Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL	Quantity Limits Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST	Step Therapy Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR	Other Restrictions Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.

Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.

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