Dosing & Uses
Dosage Forms & Strengths
nasal spray
- 0.25%
- 0.5%
- 1%
Nasal Congestion
Instill 2-3 sprays or 2-3 gtt q4hr of 0.25-0.1% solution PRN; not to exceed 3 days
Dosage Forms & Strengths
nasal spray
- 0.25%
- 0.5%
- 1%
Nasal Congestion
<2 years
- Consult a physician
2-6 years
- 1-3 gtt intranasally q2-4hr of 0.125% solution PRN; not to exceed 3 days
6-12 years
- 2-3 gtt intranasally q4hr of 0.25% solution PRN; not to exceed 3 days
>12 years old
- Instill 1-2 sprays or 1-2 gtt intranasally q4hr of 0.25-0.1% solution PRN; not to exceed 3 days
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (0)
Serious - Use Alternative (0)
Monitor Closely (2)
- nicotine intranasal
phenylephrine nasal decreases levels of nicotine intranasal by Other (see comment). Use Caution/Monitor. Comment: Nasal vasoconstrictors prolong the time to peak concentrations by ~40% and decreases peak concentration by ~20%.
- safinamide
phenylephrine nasal and safinamide both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor patients for hypertension if safinamide is prescribed concomitantly with prescription or nonprescription sympathomimetics, including nasal, oral, or ophthalmic decongestants and cold remedies.
Minor (0)
Adverse Effects
Frequency Not Defined
Stinging
Dryness
Rebound congestion
Sneezing
Burning
Warnings
Contraindications
Hypersensitivity to product or excipients
Use for >3 days
Cautions
Rebound congestion may occur
Temporary discomfort such as burning, stinging, sneezing, or an increase in nasal discharge may occur
Use of container by more than one person may spread infection
Use only as directed; frequent or prolonged use may cause nasal congestion to recur or worsen
Ask a healthcare professional before in heart disease, high blood pressure, thyroid disease, diabetes, trouble urinating due to an enlarged prostate gland
Stop use and ask healthcare professional if symptoms persist
Stop use if symptoms persist
Pregnancy & Lactation
Pregnancy Category: C
Lactation: not known if excreted in breast milk
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Alpha adrenergic agonist; stimulates alpha-adrenergic receptors in nasal conjunctiva and arterioles to produce vasoconstriction that results in nasal decongestion
Pharmacokinetics
Absorption: Minimal systemic
Duration: 2.5 - 4 hr
Onset: < 2 min
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
Neo-Synephrine (phenylephrine) nasal - | 1 % liquid | ![]() | |
Neo-Synephrine (phenylephrine) nasal - | 0.5 % liquid | ![]() | |
Neo-Synephrine (phenylephrine) nasal - | 0.25 % liquid | ![]() | |
Neo-Synephrine (phenylephrine) nasal - | 1 % liquid | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
phenylephrine injection - | 10 mg/mL vial | ![]() | |
Nasal Four nasal - | 1 % liquid | ![]() | |
4 Way nasal - | 1 % liquid | ![]() | |
Ephrine nasal - | 1 % drops | ![]() | |
Sinus PE Decongestant oral - | 10 mg tablet | ![]() | |
Nasal Decongestant (phenylephrine) oral - | 10 mg tablet | ![]() | |
Sinus Decongestant (PE) oral - | 10 mg tablet | ![]() | |
Sinus Decongestant (PE) oral - | 10 mg tablet | ![]() | |
Sinus Decongestant (PE) oral - | 10 mg tablet | ![]() | |
Wal-Four nasal - | 1 % liquid | ![]() | |
Wal-Four nasal - | 1 % liquid | ![]() | |
Vazculep injection - | 10 mg/mL vial | ![]() | |
Vazculep injection - | 10 mg/mL vial | ![]() | |
Vazculep injection - | 10 mg/mL vial | ![]() | |
Vazculep injection - | 10 mg/mL vial | ![]() | |
Vazculep injection - | 10 mg/mL vial | ![]() | |
Wal-phed PE oral - | 10 mg tablet | ![]() | |
phenylephrine ophthalmic (eye) - | 10 % drops | ![]() | |
phenylephrine ophthalmic (eye) - | 2.5 % drops | ![]() | |
phenylephrine ophthalmic (eye) - | 10 % drops | ![]() | |
phenylephrine ophthalmic (eye) - | 2.5 % drops | ![]() | |
phenylephrine ophthalmic (eye) - | 2.5 % drops | ![]() |
Copyright © 2010 First DataBank, Inc.
Patient Handout
phenylephrine nasal
DECONGESTANT DROPS - NASAL
USES: This medication is used for temporary relief of congestion in the nose caused by various conditions including the common cold, sinusitis, hay fever, and allergies. It works by narrowing the blood vessels in the nose area, reducing swelling and congestion.
HOW TO USE: Use this medication in the nose as directed. Follow all directions on the product package, or use as directed by your doctor. If you have any questions, ask your doctor or pharmacist.To apply nasal drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your nose or any other surface. If needed, have another person place the drops in your nose.Gently blow your nose before using this drug. Tilt your head back while sitting on a chair or lying down. Hold the dropper over the affected nostril and apply the directed number of drops. Keep your head tilted for a few minutes. Repeat these steps with the other nostril if needed. Do not swallow the medication if it drips into the throat.This medication provides only temporary relief. Do not use more medication or use it more often or for longer than directed because doing so may increase the risk of side effects. Also, do not use this medication for more than 3 days because doing so may cause a condition called rebound congestion. Symptoms of rebound congestion include long-term redness and swelling inside the nose and increased runny nose. If this occurs, stop using this medication and consult your doctor or pharmacist.Inform your doctor if your condition gets worse or lasts after 3 days.
SIDE EFFECTS: Temporary burning, stinging, dryness in the nose, runny nose, and sneezing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: slow/fast/pounding heartbeat, dizziness, nausea, headache, mental/mood changes, trouble sleeping, shaking (tremors), unusual sweating, unusual weakness.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using this nasal decongestant, tell your doctor or pharmacist if you are allergic to it; or to other sympathomimetics (such as pseudoephedrine); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.If you have any of the following health problems, consult your doctor or pharmacist before using this product: heart/blood vessel disease (such as coronary artery disease), overactive thyroid (hyperthyroidism), diabetes, high blood pressure, difficulty urinating (due to enlarged prostate).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Children may be more sensitive to the side effects of this drug. Check the product package or consult with your doctor or pharmacist about whether these nasal drops can be used by children.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.Some products have ingredients that could raise your heart rate or blood pressure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products or diet aids).
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: drowsiness, slow heartbeat, dizziness, fainting.
NOTES: Do not share this medication with others. Use of this container by more than one person may spread infection.There are many nasal decongestants available, many without a prescription. Talk with your doctor or pharmacist about which product is best for you.
MISSED DOSE: Not applicable.
STORAGE: Refer to storage information printed on the package. Protect from heat and light. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised November 2022. Copyright(c) 2022 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.