phenylephrine nasal (OTC)

Brand and Other Names:NeoSynephrine Nasal, Neo-Synephrine Cold & Sinus Mild Strength Spray
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

nasal spray

  • 0.125%
  • 0.25%
  • 0.5%
  • 1%

Nasal Congestion

Instill 2-3 sprays or 2-3 gtt q4hr of 0.25-0.1% solution PRN; not to exceed 3 days

Dosage Forms & Strengths

nasal spray

  • 0.125%
  • 0.25%
  • 0.5%
  • 1%

Nasal Congestion

<2 years

  • Consult a physician

2-6 years

  • 1-3 gtt intranasally q2-4hr of 0.125% solution PRN; not to exceed 3 days

6-12 years

  • 2-3 gtt intranasally q4hr of 0.25% solution PRN; not to exceed 3 days

>12 years old

  • Instill 1-2 sprays or 1-2 gtt intranasally q4hr of 0.25-0.1% solution PRN; not to exceed 3 days
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Interactions

Interaction Checker

and phenylephrine nasal

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (2)

                • nicotine intranasal

                  phenylephrine nasal decreases levels of nicotine intranasal by Other (see comment). Use Caution/Monitor. Comment: Nasal vasoconstrictors prolong the time to peak concentrations by ~40% and decreases peak concentration by ~20%.

                • safinamide

                  phenylephrine nasal and safinamide both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor patients for hypertension if safinamide is prescribed concomitantly with prescription or nonprescription sympathomimetics, including nasal, oral, or ophthalmic decongestants and cold remedies.

                Minor (0)

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                  Adverse Effects

                  Frequency Not Defined

                  Stinging

                  Dryness

                  Rebound congestion

                  Sneezing

                  Burning

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                  Warnings

                  Contraindications

                  Cardiac disease (hypertension, HR, palpitations)

                  Nonselective MAO inhibitors: Risk of hypertensive reaction

                  Cautions

                  Rebound congestion may occur

                  Use caution in DM and hypertension

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                  Pregnancy & Lactation

                  Pregnancy Category: C

                  Lactation: not known if excreted in breast milk

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Alpha adrenergic agonist; stimulates alpha-adrenergic receptors in nasal conjunctiva and arterioles to produce vasoconstriction that results in nasal decongestion

                  Pharmacokinetics

                  Absorption: Minimal systemic

                  Duration: 2.5 - 4 hr

                  Onset: < 2 min

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                  Images

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                  Patient Handout

                  A Patient Handout is not currently available for this monograph.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.