phenylephrine nasal (OTC)

Brand and Other Names:NeoSynephrine Nasal, Neo-Synephrine Cold & Sinus Mild Strength Spray

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

nasal spray

  • 0.25%
  • 0.5%
  • 1%

Nasal Congestion

Instill 2-3 sprays or 2-3 gtt q4hr of 0.25-0.1% solution PRN; not to exceed 3 days

Dosage Forms & Strengths

nasal spray

  • 0.25%
  • 0.5%
  • 1%

Nasal Congestion

<2 years

  • Consult a physician

2-6 years

  • 1-3 gtt intranasally q2-4hr of 0.125% solution PRN; not to exceed 3 days

6-12 years

  • 2-3 gtt intranasally q4hr of 0.25% solution PRN; not to exceed 3 days

>12 years old

  • Instill 1-2 sprays or 1-2 gtt intranasally q4hr of 0.25-0.1% solution PRN; not to exceed 3 days
Next:

Interactions

Interaction Checker

and phenylephrine nasal

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (1)

              • zavegepant intranasal

                phenylephrine nasal will decrease the level or effect of zavegepant intranasal by Other (see comment). Avoid or Use Alternate Drug. Avoid coadministration of intranasal decongestants with zavegepant intranasal. If unavoidable, administer intranasal decongestants at least 1 hr after zavegepant.

              Monitor Closely (2)

              • nicotine intranasal

                phenylephrine nasal decreases levels of nicotine intranasal by Other (see comment). Use Caution/Monitor. Comment: Nasal vasoconstrictors prolong the time to peak concentrations by ~40% and decreases peak concentration by ~20%.

              • safinamide

                phenylephrine nasal and safinamide both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Monitor patients for hypertension if safinamide is prescribed concomitantly with prescription or nonprescription sympathomimetics, including nasal, oral, or ophthalmic decongestants and cold remedies.

              Minor (0)

                Previous
                Next:

                Adverse Effects

                Frequency Not Defined

                Stinging

                Dryness

                Rebound congestion

                Sneezing

                Burning

                Previous
                Next:

                Warnings

                Contraindications

                Hypersensitivity to product or excipients

                Use for >3 days

                Cautions

                Rebound congestion may occur

                Temporary discomfort such as burning, stinging, sneezing, or an increase in nasal discharge may occur

                Use of container by more than one person may spread infection

                Use only as directed; frequent or prolonged use may cause nasal congestion to recur or worsen

                Ask a healthcare professional before in heart disease, high blood pressure, thyroid disease, diabetes, trouble urinating due to an enlarged prostate gland

                Stop use and ask healthcare professional if symptoms persist

                Stop use if symptoms persist

                Previous
                Next:

                Pregnancy & Lactation

                Pregnancy Category: C

                Lactation: not known if excreted in breast milk

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

                Previous
                Next:

                Pharmacology

                Mechanism of Action

                Alpha adrenergic agonist; stimulates alpha-adrenergic receptors in nasal conjunctiva and arterioles to produce vasoconstriction that results in nasal decongestion

                Pharmacokinetics

                Absorption: Minimal systemic

                Duration: 2.5 - 4 hr

                Onset: < 2 min

                Previous
                Next:

                Images

                BRAND FORM. UNIT PRICE PILL IMAGE
                Vazculep injection
                -
                10 mg/mL vial
                Vazculep injection
                -
                10 mg/mL vial
                Vazculep injection
                -
                10 mg/mL vial
                Vazculep injection
                -
                10 mg/mL vial
                Vazculep injection
                -
                10 mg/mL vial
                Wal-Four nasal
                -
                1 % liquid
                Wal-Four nasal
                -
                1 % liquid
                Neo-Synephrine (phenylephrine) nasal
                -
                1 % liquid
                Neo-Synephrine (phenylephrine) nasal
                -
                0.5 % liquid
                Neo-Synephrine (phenylephrine) nasal
                -
                0.25 % liquid
                Neo-Synephrine (phenylephrine) nasal
                -
                1 % liquid
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                phenylephrine injection
                -
                10 mg/mL vial
                Sinus Decongestant (PE) oral
                -
                10 mg tablet
                Sinus Decongestant (PE) oral
                -
                10 mg tablet
                Sinus Decongestant (PE) oral
                -
                10 mg tablet
                Sinus PE Decongestant oral
                -
                10 mg tablet
                Nasal Decongestant (phenylephrine) oral
                -
                10 mg tablet
                Ephrine nasal
                -
                1 % drops
                Nasal Four nasal
                -
                1 % liquid
                Wal-phed PE oral
                -
                10 mg tablet
                4 Way nasal
                -
                1 % liquid
                phenylephrine ophthalmic (eye)
                -
                10 % drops
                phenylephrine ophthalmic (eye)
                -
                2.5 % drops
                phenylephrine ophthalmic (eye)
                -
                2.5 % drops
                phenylephrine ophthalmic (eye)
                -
                10 % drops
                phenylephrine ophthalmic (eye)
                -
                2.5 % drops

                Copyright © 2010 First DataBank, Inc.

                Previous
                Next:

                Patient Handout

                Select a drug:
                Patient Education
                phenylephrine injection

                NO MONOGRAPH AVAILABLE AT THIS TIME

                USES: Consult your pharmacist.

                HOW TO USE: Consult your pharmacist.

                SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                PRECAUTIONS: Consult your pharmacist.

                DRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

                OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

                NOTES: No monograph available at this time.

                MISSED DOSE: Consult your pharmacist.

                STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                Information last revised July 2016. Copyright(c) 2023 First Databank, Inc.

                IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

                Previous
                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.