Nadh (Herb/Suppl)

Chronic fatigue syndrome, improving mental clarity, alertness, and concentration, depression, jet lag, hypertension

Parkinson's disease, Alzheimer's disease

Efficacy

Insufficient information; positive results only from pilot studies or open-label studies

Dementia: Ineffective for mild to mod dementia from Alzheimer's

None reported

Contraindications

Hypersensitivity to any component of oral product

Pregnancy Category: N/A

Lactation: N/A

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Metabolism: N/A

Excretion: N/A

Mechanism of Action

Coenzyme involved in ATP production (glycolysis, citric acid cycle, electron transport chain)

May increase tyrosine hydroxylase-mediated dopamine production