Dosing & Uses
Desmoid Tumors
Pending FDA approval for treatment of desmoid tumors
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Pharmacology
Mechanism of Action
Gamma secretase cleaves multiple transmembrane proteins, including Notch, that are believed to play a role in activating pathways that contribute to growth of desmoid tumors
Gamma secretase has been shown to cleave B-cell maturation antigen (BCMA), a therapeutic target that is specifically expressed on multiple myeloma cells
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Images
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.
