nirogacestat (Pending FDA Approval)

Brand and Other Names:
  • Print

Dosing & Uses

Desmoid Tumors

Pending FDA approval for treatment of desmoid tumors

Next:

Pharmacology

Mechanism of Action

Gamma secretase cleaves multiple transmembrane proteins, including Notch, that are believed to play a role in activating pathways that contribute to growth of desmoid tumors

Gamma secretase has been shown to cleave B-cell maturation antigen (BCMA), a therapeutic target that is specifically expressed on multiple myeloma cells

Previous
Next:

Images

Pricing & Images are not currently available for this monograph.
Previous
Next:

Patient Handout

A Patient Handout is not currently available for this monograph.
Previous
Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.