Dosing & Uses
Dosage Forms & Strengths
spray
- 0.4mg/spray
Angina
1-2 spray(s) PRN for angina, may repeat q3-5min, not to exceed 3 sprays in 15 minutes
Spray onto or under tongue; do not inhale, expectorate or rinse mouth for 5-10 minutes
Seek medical attention if pain persists after 3 doses in 15 minutes
Angina, Prophylaxis
1-2 sprays 5-10 minutes before activities likely to cause angina
Renal Failure
CrCl: 10-50 mg/min: Administer q24-72hr
CrCl<10 mL/min: Administer q72-96hr
Not approved
Angina
Angina1-2 spray(s) PRN for angina, may repeat q3-5min, not to exceed 3 sprays in 15 minutes
Spray onto or under tongue; do not inhale, expectorate or rinse mouth for 5-10 minutes
Seek medical attention if pain persists after 3 doses in 15 minutes
Angina, prophylaxis
1-2 sprays 5-10 minutes before activities likely to cause angina
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Contraindicated (12)
- avanafil
nitroglycerin translingual, avanafil. Mechanism: additive vasodilation. Contraindicated. Potentially fatal hypotension.
- bromocriptine
bromocriptine decreases effects of nitroglycerin translingual by pharmacodynamic antagonism. Contraindicated.
- cabergoline
cabergoline decreases effects of nitroglycerin translingual by pharmacodynamic antagonism. Contraindicated.
- dihydroergotamine
dihydroergotamine decreases effects of nitroglycerin translingual by pharmacodynamic antagonism. Contraindicated.
- dihydroergotamine intranasal
dihydroergotamine intranasal decreases effects of nitroglycerin translingual by pharmacodynamic antagonism. Contraindicated.
- ergoloid mesylates
ergoloid mesylates decreases effects of nitroglycerin translingual by pharmacodynamic antagonism. Contraindicated.
- ergotamine
ergotamine decreases effects of nitroglycerin translingual by pharmacodynamic antagonism. Contraindicated.
- methylergonovine
methylergonovine decreases effects of nitroglycerin translingual by pharmacodynamic antagonism. Contraindicated.
- riociguat
nitroglycerin translingual, riociguat. Either increases effects of the other by additive vasodilation. Contraindicated. Coadministration of nitrates or nitric oxide donors is contraindicated due to risk of hypotension.
- sildenafil
nitroglycerin translingual, sildenafil. Mechanism: additive vasodilation. Contraindicated. Potentially fatal hypotension.
- tadalafil
nitroglycerin translingual, tadalafil. Mechanism: additive vasodilation. Contraindicated. Potentially fatal hypotension.
- vardenafil
nitroglycerin translingual, vardenafil. Mechanism: additive vasodilation. Contraindicated. Potentially fatal hypotension.
Serious - Use Alternative (5)
- cabergoline
nitroglycerin translingual increases effects of cabergoline by decreasing metabolism. Avoid or Use Alternate Drug. Risk of increased SBP, angina pectoris.
- ergoloid mesylates
nitroglycerin translingual increases effects of ergoloid mesylates by decreasing metabolism. Avoid or Use Alternate Drug. Risk of increased SBP, angina pectoris.
- ergotamine
nitroglycerin translingual increases effects of ergotamine by decreasing metabolism. Avoid or Use Alternate Drug. Risk of increased SBP, angina pectoris.
- lofexidine
lofexidine, nitroglycerin translingual. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension.
- methylergonovine
nitroglycerin translingual increases effects of methylergonovine by decreasing metabolism. Avoid or Use Alternate Drug. Risk of increased SBP, angina pectoris.
Monitor Closely (5)
- arginine
nitroglycerin translingual, arginine. Mechanism: additive vasodilation. Use Caution/Monitor. Possible hypotension.
- bretylium
nitroglycerin translingual, bretylium. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Each drug may cause hypotension.
- bupivacaine implant
nitroglycerin translingual, bupivacaine implant. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Local anesthetics may increase the risk of developing methemoglobinemia when concurrently exposed to drugs that also cause methemoglobinemia.
- dapsone topical
nitroglycerin translingual increases toxicity of dapsone topical by altering metabolism. Modify Therapy/Monitor Closely. May induce methemoglobinemia.
- tetracaine
tetracaine, nitroglycerin translingual. Other (see comment). Use Caution/Monitor. Comment: Monitor for signs of methemoglobinemia when methemoglobin-inducing drugs are coadministered.
Minor (3)
- acetylcysteine
acetylcysteine increases effects of nitroglycerin translingual by Other (see comment). Minor/Significance Unknown. Comment: Acetylcysteine may enhance vasodilatory effects of nitroglycerin.
- acetylcysteine (Antidote)
acetylcysteine (Antidote) increases effects of nitroglycerin translingual by Other (see comment). Minor/Significance Unknown. Comment: Acetylcysteine may enhance vasodilatory effects of nitroglycerin.
- ethanol
nitroglycerin translingual, ethanol. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Possible hypotension.
Adverse Effects
Common
Headache
Hypotension
Tachycardia
Dizziness
Lightheadedness
Blurred vision
Flushing
N/V
Nervousness
Xerostomia
Serious
Methemoglobinemia (rare)
Syncope
Prolonged bleeding time
Exfoliative dermatitis
Unstable angina
Rebound hypertension
Thrombocytopenia
Hypersensitivity
Warnings
Contraindications
Hypersensitivity
AMI, severe anemia
Recent use (within several days) of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, or vardenafil) may cause dangerously low hypotension; the time course of the interaction appears to be related to the PDE-5 inhibitor half-life
Soluble guanylate cyclase (sGC) stimulator, riociguat; coadministration may cause hypotension
Narrow angle glaucoma (controversial: may not be clinically significant)
Increased intracranial pressure
Circulatory failure or shock
Cautions
CHF, alcohol use, glaucoma, hyperthyroidism, hypertrophic cardiomyopathy, increased ICP (eg, head trauma, cerebral hemorrhage; potential contraindication), increased IOP, postural hypotension, volume depletion, low systolic BP
Severe hypotension may occur with small doses especially in patients with constrictive pericarditis, aortic or mitral stenosis, volume depleted patients or that are already hypotensive; hypotension may be accompanied by paradoxical bradycardia and/or increased angina pectoris
Do not change brands unintentionally as not all are bioequivalent
Treat drug-induced headache with aspirin or acetaminophen
Provide nitrate-free interval (10-12 hr or overnight) to avoid development of tolerance; excessive use my lead to development of tolerance
Inability to relieve chest pain after 3 doses may mean AMI-rush to ER if possible
Discontinue if blurred vision develops
Prime pump prior to first use or after prolonged nonuse
Use supportive treatment in overdose
May aggravate the angina caused by hypertrophic obstructive cardiomyopathy
Nitroglycerin produces dose-related headaches, especially at the start of nitroglycerin therapy, which may be severe and persistent but usually subside with continued use
Dose selection for elderly should start at low end of dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy
Pregnancy & Lactation
Pregnancy
Limited published data on the use of nitroglycerin are insufficient to determine a drug-associated risk of major birth defects or miscarriage; in animal reproduction studies, there were no adverse developmental effects when nitroglycerin was administered intravenously to rabbits or intraperitoneally to rats during organogenesis at doses greater than 64-times the human dose
Lactation
Sublingual nitroglycerin has not been studied in lactating women; not known if drug is present in human milk, or if nitroglycerin has effects on milk production or the breastfed child; therefore, the developmental and health benefits of breastfeeding should be considered along with the mother’s need for nitroglycerin and any potential adverse effects on breastfed child from nitroglycerin or from underlying maternal condition
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Organic nitrate which causes systemic venodilation, decreasing preload
Cellular mechanism: nitrate enters vascular smooth muscle & converted to nitric oxide (NO) leading to production of cGMP & vasodilation
Relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both preload and afterload, and myocardial O2 demand
Also improves coronary collateral circulation. Lower BP, increase HR, occasional paradoxical bradycardia
Pharmacokinetics
Half-Life: 1-4 min
Onset: 2 min
Duration: Up to 1 hr
Protein Bound: 11-60%
Vd: 3 L/kg
Metabolism: Mainly in liver, extrahepatic sites: vascular wall, RBC
Metabolites: 1,3-glyceryl dinitrate, 1,2-glyceryl dinitrate, & glyceryl mononitrate (inactive)
Clearance: 5.5-11 L/min
Excretion: Urine
Dialyzable: No
Images
BRAND | FORM. | UNIT PRICE | PILL IMAGE |
---|---|---|---|
nitroglycerin translingual - | 400 mcg/spray solution | ![]() | |
nitroglycerin translingual - | 400 mcg/spray solution | ![]() | |
nitroglycerin translingual - | 400 mcg/spray solution | ![]() | |
nitroglycerin translingual - | 400 mcg/spray solution | ![]() | |
nitroglycerin oral - | 2.5 mg capsule | ![]() | |
nitroglycerin oral - | 9 mg capsule | ![]() | |
nitroglycerin oral - | 6.5 mg capsule | ![]() | |
Nitro-Bid transdermal - | 2 % ointment | ![]() | |
Nitro-Bid transdermal - | 2 % ointment | ![]() | |
Nitro-Bid transdermal - | 2 % ointment | ![]() | |
nitroglycerin intravenous - | 50 mg/10 mL (5 mg/mL) vial | ![]() | |
nitroglycerin transdermal - | 0.6 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.4 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.4 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.2 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.1 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.6 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.4 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.2 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.4 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.6 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.2 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.2 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.6 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.4 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.2 mg/hr transdermal system | ![]() | |
nitroglycerin transdermal - | 0.1 mg/hr transdermal system | ![]() | |
Nitro-Dur transdermal - | 0.3 mg/hr transdermal system | ![]() | |
Nitromist translingual - | 400 mcg/spray aerosol | ![]() | |
GoNitro sublingual - | 400 mcg powder | ![]() | |
GoNitro sublingual - | 400 mcg powder | ![]() | |
Rectiv rectal - | 0.4 % (w/w) ointment | ![]() | |
nitroglycerin sublingual - | 0.4 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.4 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.3 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.6 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.6 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.6 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.3 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.4 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.4 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.4 mg tablet | ![]() | |
nitroglycerin sublingual - | 0.4 mg tablet | ![]() | |
Nitrostat sublingual - | 0.4 mg tablet | ![]() | |
Nitrostat sublingual - | 0.6 mg tablet | ![]() | |
Nitrostat sublingual - | 0.4 mg tablet | ![]() | |
Nitrostat sublingual - | 0.3 mg tablet | ![]() | |
Nitro-Time oral - | 9 mg capsule | ![]() | |
Nitro-Time oral - | 6.5 mg capsule | ![]() | |
Nitro-Time oral - | 2.5 mg capsule | ![]() | |
Nitrolingual translingual - | 400 mcg/spray solution | ![]() | |
Nitrolingual translingual - | 400 mcg/spray solution | ![]() |
Copyright © 2010 First DataBank, Inc.
Patient Handout
nitroglycerin translingual
NITROGLYCERIN SPRAY - LINGUAL
(NYE-troe-GLIS-er-in)
COMMON BRAND NAME(S): Nitrolingual
USES: This medication is used to relieve chest pain (angina) in people that have a certain heart condition (coronary artery disease). It may also be used before physical activities (such as exercise, sexual activity) to help prevent chest pain.Nitroglycerin belongs to a class of drugs known as nitrates. Angina occurs when the heart muscle is not getting enough blood. This drug works by relaxing and widening blood vessels so blood can flow more easily to the heart.
HOW TO USE: Ask your doctor now for exact instructions on how to use your nitroglycerin and when to call for emergency medical help (911).Read the Patient Information Leaflet available from your pharmacist. Consult your doctor or pharmacist if you have any questions.Before using this medication for the first time, spray the pump into the air away from yourself, others, or open flame. This is known as priming the pump. The number of times you need to spray the pump to prime it depends on your brand. If you have not used this medication for 6 weeks or more, you will need to prime it again before use. Do not shake the container.Sit down before using this medication. Remove the plastic cover. Hold the container upright with your finger on top of the grooved button. Open your mouth, and bring the container as close to your mouth as possible. Press the button to spray the medication onto or under your tongue. Use 1 to 2 sprays as directed by your doctor, then close your mouth. Do not inhale or swallow the spray. Avoid eating, spitting, or rinsing your mouth for 5 to 10 minutes after spraying.If you are using this medication to prevent chest pain before physical activities, use it 5 to 10 minutes before the activity.If you are using this medication to relieve chest pain once it occurs, use it as soon as possible. If your chest pain has not improved or if it has worsened 5 minutes after you use this drug, call emergency medical help (911). After calling the emergency number, use another spray. Five minutes after the second spray, if you still have chest pain and the ambulance has not arrived, use a third spray. If your chest pain is not gone after 15 minutes and 3 doses of nitroglycerin, call emergency medical help (911) if you have not called already. Do not use more than 3 sprays during an attack unless directed by your doctor.Periodically check the level of medication in the container so you know when you need to order more medication.
SIDE EFFECTS: Headache, dizziness, lightheadedness, nausea, and flushing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Headache is often a sign that this medication is working. Your doctor may recommend treating headaches with an over-the-counter pain reliever (such as acetaminophen, aspirin). If the headaches continue or become severe, tell your doctor promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: fainting, fast/irregular/pounding heartbeat.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as isosorbide mononitrate); or to nitrites; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: recent head injury, anemia, low blood pressure, dehydration, other heart problems (such as recent heart attack).This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Older adults may be more sensitive to the side effects of this medication, especially dizziness and lightheadedness which could increase the risk of falls.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this medication passes into breast milk or if it may harm a nursing infant. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: drugs used to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), certain drugs to treat migraine headaches (ergot alkaloids such as ergotamine), riociguat, vericiguat.This medication may interfere with certain laboratory tests (including blood cholesterol levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slow heartbeat, vision changes, severe nausea/vomiting, sweating, cold/clammy skin, bluish fingers/toes/lips.
NOTES: Do not share this medication with others.
MISSED DOSE: Not applicable.
STORAGE: Store at room temperature away from light, heat and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).
Information last revised October 2022. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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