ethyl alcohol intranasal (OTC)

Brand and Other Names:Nozin Nasal Sanitizer
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

nasal swab

  • 62% (0.5mL prefilled ampule [POPswab])
  • Inactive ingredients: jojoba, orange oil, coconut oil, lauric acid, benzalkonium chloride, and vitamin E

Nasal Bacterial Decolonization

Used for nasal decolonization as part of infection control measures to reduce nasal carriage bacteria (eg, S aureus) to lower the risk of nasal pathogen transmission

Swab nose as directed; not to exceed 4 times/day (see Administration)

Dosing Considerations

Use in healthcare providers

  • Hospital healthcare providers who tested positive for S aureus nasal carriage were treated with 3 applications at 4-hr intervals during the workday
  • Antiseptic use reduced colony forming units from baseline by 99% (median) and 82% (mean) (P <0.001) compared with placebo
  • Total bacterial colony forming units were reduced by 91% (median) and 71% (mean) (P <0.001) compared with placebo
  • Am J Infect Control. 2014 August;42(8):841-846

Use in other populations

  • Part of postoperative/discharge care in patients and caregivers who are carriers
  • Use in S aureus nasal carriers instead of isolation

Dosage Forms & Strengths

nasal swab

  • 62% (0.5mL prefilled ampule [POPswab])
  • Inactive ingredients: jojoba, orange oil, coconut oil, lauric acid, benzalkonium chloride, and vitamin E

Nasal Bacterial Decolonization

Used for nasal decolonization as part of infection control measures to reduce nasal carriage bacteria (eg, S aureus) to lower the risk of nasal pathogen transmission

Swab nose as directed; not to exceed 4 times/day (see Administration)

Dosing Considerations

Use in healthcare providers

  • Hospital healthcare providers who tested positive for S aureus nasal carriage were treated with 3 applications at 4-hr intervals during the workday
  • Antiseptic use reduced colony forming units from baseline by 99% (median) and 82% (mean) (P <0.001) compared with placebo
  • Total bacterial colony forming units were reduced by 91% (median) and 71% (mean) (P <0.001) compared with placebo
  • Am J Infect Control. 2014 August;42(8):841-846

Use in other populations

  • Part of postoperative/discharge care in patients and caregivers who are carriers
  • Use in S aureus nasal carriers instead of isolation
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Adverse Effects

Frequency Not Defined

Irritation

Erythema

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Warnings

Contraindications

Hypersensitivity

Cautions

Do not use in the eyes, on mucous membranes, with history of nasal bleeding or irritation, or if allergic to any of the ingredients

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Unknown if distributed in human breast milk

Pregnant or breastfeeding patients should seek advice of a healthcare professional before using OTC drugs

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Nonantibiotic antiseptic (ie, ethyl alcohol)

Used as part of an overall infection control plan to decolonize Staphylococcus aureus and other bacteria in the nasal cavity

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Administration

Intranasal Administration

1. Flip ampule around in paper sleeve to expose swab tip

2. Shake well

3. With sleeve on ampule, crush at dot to pop, then squeeze to wet swab tip

4. Swab around nostril rims 4 times in each direction

5. Caution: Do not extend in nose beyond swab tip; apply to skin only

6. Discard after single use

Storage

Store in cool, dry place between 59-84°F

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Images

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.