COVID-19 vaccine, subunit-Novavax (Investigational)

Brand and Other Names:NVX-CoV2373 (Novavax)
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Dosing & Uses

COVID-19 Disease Prevention

Pending FDA approval for prevention of coronavirus disease 2019 (COVID-19) infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Several vaccines are in late phase 3 clinical trials in the United States

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Pharmacology

Mechanism of Action

The goal of vaccination is to elicit long-term antigen-specific antibody responses by plasma cells and to develop persistent T-cell and B-cell memory of the antigen (ie, humoral and cellular immune response)

A portion of the viral antigen from the spike (S) protein is used to create the vaccine; once vaccinated, an immune response is elicited to the protein subunit

Vaccine contains an adjuvant (ie, saponin-based Matrix-MTM) to enhance immune response and stimulate high levels of neutralizing antibodies

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.