acetaminophen IV (Rx)

Brand and Other Names:Ofirmev
  • Print

Dosing & Uses

AdultPediatricGeriatric

Dosage Forms & Strengths

injectable, ready-to-use IV solution

  • 500mg/50mL
  • 1000mg/100mL

Pain & Fever

Indicated for mild-to-moderate pain and moderate-to-severe pain with adjunctive opioid analgesics; also indicated for reduction of fever

<50 kg: 12.5 mg/kg IV q4hr OR 15 mg/kg IV q6hr; not to exceed 750 mg/dose or 3.75 g/day  

≥50 kg: 650 mg IV q4hr OR 1000 mg IV q6hr; not to exceed 4 g/day

Infuse IV over at least 15 minutes (also see Administration)

Dosage Modifications

Severe renal impairment (CrCl <30 mL/min): Longer dosing intervals and a reduced total daily dose may be warranted

Hepatic impairment

  • Severe hepatic impairment or severe active liver disease: Contraindicated
  • Mild-to-moderate hepatic impairment or active liver disease: Use caution; a reduced total daily dose may be warranted

Dosage Forms & Strengths

injectable, ready-to-use IV solution

  • 500mg/50mL
  • 1000mg/100mL

Pain

Indicated for the management of mild-to-moderate pain in pediatric patients aged ≥2 years; also indicated for management of moderate-to-severe pain with adjunctive opioid analgesics in children aged ≥2 years

Also see Administration

<2 years: Safety and efficacy not established

2-12 years: 12.5 mg/kg IV q4hr OR 15 mg/kg IV q6hr; not to exceed 75 mg/kg/day  

≥13 years

  • <50 kg: 12.5 mg/kg IV q4hr OR 15 mg/kg IV q6hr; not to exceed 750 mg/dose or 3.75 g/day
  • ≥50 kg: 650 mg IV q4hr OR 1000 mg IV q6hr; not to exceed 4 g/day

Fever

Indicated for reduction of fever

Also see Administration

Neonates

  • Neonates, including premature neonates born at ≥32 weeks gestational age, up to 28 days chronological age
  • 12.5 mg/kg IV q6hr
  • Maximum daily dose is 50 mg/kg/day, with a minimum dosing interval of 6 hr

Infants

  • 29 days to 2 years
  • 15 mg/kg IV q6hr
  • Maximum daily dose is 60 mg/kg/day, with a minimum dosing interval of 6 hr

Children aged 2-12 years

  • 12.5 mg/kg IV q4hr OR 15 mg/kg IV q6hr; not to exceed 75 mg/kg/day
  • Maximum single dose: 750 mg

Children aged ≥13 years

  • <50 kg: 12.5 mg/kg IV q4hr OR 15 mg/kg IV q6hr; not to exceed 750 mg/dose or 3.75 g/day; maximum single dose is 750 mg
  • ≥50 kg: 650 mg IV q4hr OR 1000 mg IV q6hr; not to exceed 4 g/day

Dosage Modifications

Severe renal impairment (CrCl <30 mL/min): Longer dosing intervals and a reduced total daily dose may be warranted

Hepatic impairment

  • Severe hepatic impairment or severe active liver disease: Contraindicated
  • Mild-to-moderate hepatic impairment or active liver disease: Use caution; a reduced total daily dose may be warranted

Reduced dose and/or dosage interval may be warranted in elderly patients with decreased renal or hepatic function

Next:

Interactions

Interaction Checker

and acetaminophen IV

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

            All Interactions Sort By:
             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (1)

              • lonafarnib

                acetaminophen IV will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown.

              Monitor Closely (21)

              • atogepant

                acetaminophen IV will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • avapritinib

                acetaminophen IV will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • axitinib

                acetaminophen IV increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • busulfan

                acetaminophen IV increases levels of busulfan by decreasing metabolism. Use Caution/Monitor. Use of acetaminophen prior to (< 72 hours) or concurrently with busulfan may result in decreased clearance of busulfan due to acetaminophen-induced decreases in glutathione levels.

              • eltrombopag

                eltrombopag increases levels of acetaminophen IV by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.

              • exenatide injectable solution

                exenatide injectable solution will decrease the level or effect of acetaminophen IV by unspecified interaction mechanism. Use Caution/Monitor. To avoid potential interaction, give acetaminophen at least 1 hour before or 4 hours after exenatide injection.

              • exenatide injectable suspension

                exenatide injectable suspension will decrease the level or effect of acetaminophen IV by unspecified interaction mechanism. Use Caution/Monitor. To avoid potential interaction, give acetaminophen at least 1 hour before or 4 hours after exenatide injection.

              • finerenone

                acetaminophen IV will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor serum potassium during initiation and dosage adjustment of either finererone or moderate CYP3A4 inhibitors. Adjust finererone dosage as needed.

              • flibanserin

                acetaminophen IV will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.

              • imatinib

                imatinib decreases levels of acetaminophen IV by decreasing hepatic clearance. Modify Therapy/Monitor Closely. In vitro, imatinib was found to inhibit acetaminophen O-glucuronidation (Ki value of 58.5 micro-M) at therapeutic levels; avoid chronic acetaminophen therapy with imatinib; if occasional acetaminophen administered, do not exceed 1300 mg/day.

              • isavuconazonium sulfate

                acetaminophen IV will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • isoniazid

                isoniazid will increase the level or effect of acetaminophen IV by affecting hepatic enzyme CYP2E1 metabolism. Use Caution/Monitor.

              • ivacaftor

                acetaminophen IV increases levels of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor when coadministered with weak CYP3A4 inhibitors .

              • lemborexant

                acetaminophen IV will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.

              • levonorgestrel oral/ethinylestradiol/ferrous bisglycinate

                levonorgestrel oral/ethinylestradiol/ferrous bisglycinate will decrease the level or effect of acetaminophen IV by unknown mechanism. Use Caution/Monitor.

              • lomitapide

                acetaminophen IV increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lomitapide dose should not exceed 30 mg/day.

              • midazolam intranasal

                acetaminophen IV will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.

              • mipomersen

                mipomersen, acetaminophen IV. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.

              • tazemetostat

                acetaminophen IV will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              • tetracaine

                tetracaine, acetaminophen IV. Other (see comment). Use Caution/Monitor. Comment: Monitor for signs of methemoglobinemia when methemoglobin-inducing drugs are coadministered.

              • tinidazole

                acetaminophen IV will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

              Minor (51)

              • acetazolamide

                acetazolamide decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • albiglutide

                albiglutide decreases levels of acetaminophen IV by unspecified interaction mechanism. Minor/Significance Unknown.

              • antithrombin alfa

                acetaminophen IV increases effects of antithrombin alfa by unknown mechanism. Minor/Significance Unknown.

              • antithrombin III

                acetaminophen IV increases effects of antithrombin III by unknown mechanism. Minor/Significance Unknown.

              • argatroban

                acetaminophen IV increases effects of argatroban by unknown mechanism. Minor/Significance Unknown.

              • bemiparin

                acetaminophen IV increases effects of bemiparin by unknown mechanism. Minor/Significance Unknown.

              • bivalirudin

                acetaminophen IV increases effects of bivalirudin by unknown mechanism. Minor/Significance Unknown.

              • carbamazepine

                carbamazepine decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • cholestyramine

                cholestyramine decreases levels of acetaminophen IV by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • clonazepam

                clonazepam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • colestipol

                colestipol decreases levels of acetaminophen IV by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • dalteparin

                acetaminophen IV increases effects of dalteparin by unknown mechanism. Minor/Significance Unknown.

              • diazepam

                diazepam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • disulfiram

                disulfiram will increase the level or effect of acetaminophen IV by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.

              • enoxaparin

                acetaminophen IV increases effects of enoxaparin by unknown mechanism. Minor/Significance Unknown.

              • ethanol

                ethanol will decrease the level or effect of acetaminophen IV by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.

                ethanol increases toxicity of acetaminophen IV by decreasing metabolism. Minor/Significance Unknown.

              • ethosuximide

                ethosuximide decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • felbamate

                felbamate decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • fondaparinux

                acetaminophen IV increases effects of fondaparinux by unknown mechanism. Minor/Significance Unknown.

              • fosphenytoin

                fosphenytoin decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • gabapentin

                gabapentin decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • gabapentin enacarbil

                gabapentin enacarbil decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • green tea

                green tea increases effects of acetaminophen IV by pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical, due to caffeine content).

              • heparin

                acetaminophen IV increases effects of heparin by unknown mechanism. Minor/Significance Unknown.

              • isoniazid

                isoniazid increases toxicity of acetaminophen IV by unknown mechanism. Minor/Significance Unknown.

              • lacosamide

                lacosamide decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • lamotrigine

                lamotrigine decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • levetiracetam

                levetiracetam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • liraglutide

                liraglutide decreases levels of acetaminophen IV by unspecified interaction mechanism. Minor/Significance Unknown.

              • lorazepam

                lorazepam decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • methsuximide

                methsuximide decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • metoclopramide

                metoclopramide increases levels of acetaminophen IV by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

              • metronidazole

                metronidazole will increase the level or effect of acetaminophen IV by affecting hepatic enzyme CYP2E1 metabolism. Minor/Significance Unknown.

              • oxcarbazepine

                oxcarbazepine decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • oxybutynin

                oxybutynin decreases levels of acetaminophen IV by unspecified interaction mechanism. Minor/Significance Unknown.

              • oxybutynin topical

                oxybutynin topical decreases levels of acetaminophen IV by unspecified interaction mechanism. Minor/Significance Unknown.

              • oxybutynin transdermal

                oxybutynin transdermal decreases levels of acetaminophen IV by unspecified interaction mechanism. Minor/Significance Unknown.

              • phenindione

                acetaminophen IV increases effects of phenindione by unknown mechanism. Minor/Significance Unknown.

              • phenobarbital

                phenobarbital decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • phenytoin

                phenytoin decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • primidone

                primidone decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • protamine

                acetaminophen IV increases effects of protamine by unknown mechanism. Minor/Significance Unknown.

              • rifabutin

                rifabutin decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • rifampin

                rifampin decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • rufinamide

                rufinamide decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • ruxolitinib

                acetaminophen IV will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

              • tiagabine

                tiagabine decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • topiramate

                topiramate decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • valproic acid

                valproic acid decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              • warfarin

                acetaminophen IV increases effects of warfarin by unknown mechanism. Minor/Significance Unknown.

              • zonisamide

                zonisamide decreases levels of acetaminophen IV by increasing metabolism. Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

              Previous
              Next:

              Adverse Effects

              >10%

              Nausea (34%)

              Vomiting (15%)

              1-10%

              Headache (10%)

              Insomnia (7%)

              Pediatrics

              • Nausea (≥ 5%)
              • Vomiting (≥ 5%)
              • Constipation (≥ 5%)
              • Pruritus (≥ 5%)
              • Agitation (≥ 5%)
              • Atelectasis (≥ 5%)
              • Headache (≥ 1%)
              • Postmarketing Reports
                • Pleural effusion
                • Pulmonary edema
                • Stridor
                • Wheezing

              Frequency Not Defined

              Edema

              Hypervolemia

              Fatigue

              Hypokalemia

              Hypophosphatemia

              Hypomagnesemia

              Hypoalbuminemia

              Increased transaminase levels

              Anemia

              Infusion site pain

              Previous
              Next:

              Warnings

              Black Box Warnings

              Medication errors and hepatotoxicity

              • Take care when prescribing, preparing, and administering acetaminophen IV to avoid dosing errors which could result in accidental overdose and death
              • In particular, be careful to ensure that
                • The dose in milligrams (mg) and milliliters (mL) is not confused
                • The dosing is based on weight for patients <50 kg
                • Infusion pumps are properly programmed
                • The total daily dose of acetaminophen from all sources does not exceed maximum daily limits
              • Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death
              • Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed the maximum daily limits, and often involve more than one acetaminophen-containing product

              Contraindications

              Hypersensitivity

              Severe hepatic impairment or severe active liver disease

              Cautions

              Doses higher than recommended may result in hepatic injury, including risk of severe hepatotoxicity and death

              Do not exceed the maximum recommended daily dose

              Caution with the following conditions: hepatic impairment or active hepatic disease, in cases of alcoholism, chronic malnutrition, severe hypovolemia, G6PD deficiency, hypovolemia, or severe renal impairment (CrCl <30 mL/min)

              Discontinue immediately if symptoms associated with allergy or hypersensitivity occur

              Rare serious skin reactions reported including acute generalized exanthematous pustulosis (AGEP), Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal; discontinued at the first appearance of skin rash or any other sign of hypersensitivity

              Based on animal data use of acetaminophen may cause reduced fertility in males and females of reproductive potential; it is not known whether effects on fertility are reversible

              Previous
              Next:

              Pregnancy & Lactation

              Pregnancy

              Prolonged experience with acetaminophen in pregnant women over several decades, based on published observational epidemiological studies and case reports, did not identify a drug associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes

              Animal data

              • Animal reproduction studies have not been conducted with IV acetaminophen; reproductive and developmental studies in rats and mice from published literature identified adverse events at clinically relevant doses with acetaminophen;
              • Treatment of pregnant rats with doses of acetaminophen approximately equal to maximum human daily dose (MHDD) showed evidence of fetotoxicity and increases in bone variations in the fetuses; in another study, necrosis was observed in liver and kidney of both pregnant rats and fetuses at doses approximately equal to MHDD
              • In mice and rats treated with acetaminophen at doses within clinical dosing range, cumulative adverse effects on reproductive capacity were reported; in mice, a reduction in number of litters of parental mating pair was observed as well as retarded growth, abnormal sperm in their offspring and reduced birth weight in next generation
              • In rats, female fertility was decreased following in utero exposure to acetaminophen

              Reproductive potential

              • Based on animal data use of acetaminophen may cause reduced fertility in males and females of reproductive potential; not known whether effects on fertility are reversible
              • Published animal studies reported that oral acetaminophen treatment of male animals at doses that are 1.2 times MHDD and greater (based on body surface area comparison) result in decreased testicular weights, reduced spermatogenesis, and reduced fertility
              • In female animals given same doses, reduced implantation sites were reported; additional published animal studies indicate that acetaminophen exposure in utero adversely impacts reproductive capacity of both male and female offspring at clinically relevant exposures

              Lactation

              There is no information regarding presence of acetaminophen in human milk, effects on breastfed infant, or on milk production; however, limited published studies report that acetaminophen passes rapidly into human milk with similar levels in milk and plasma

              Average and maximum neonatal doses of 1% and 2%, respectively, of weight-adjusted maternal dose are reported after single oral administration of 1 gram APAP

              There is one well-documented report of a rash in a breast-fed infant that resolved when mother stopped acetaminophen use and recurred when she resumed acetaminophen use

              Developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for acetaminophen injection and any potential adverse effects on breastfed infant from acetaminophen injection or from underlying maternal condition

              Pregnancy Categories

              A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

              B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

              C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

              D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

              X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

              NA: Information not available.

              Previous
              Next:

              Pharmacology

              Mechanism of Action

              Inhibits prostaglandin synthesis in the CNS and works peripherally to block pain impulse generation; acts on hypothalamus to produce antipyresis

              Pharmacokinetics

              Half-Life: 2.4 hr (adolescents); 2-3 hr (adults); 2-5 hr (children); 4-10 hr (neonates)

              Vd: 0.8 L/kg

              Peak plasma time: 0.25 hr (at end of infusion)

              Peak plasma concentration: 28 mcg/mL

              Metabolism: by conjugation with glucuronide, conjugation with sulfate, and oxidation via the cytochrome P450 enzyme pathway, primarily CYP2E1, to form a reactive intermediate metabolite (N-acetyl-p-benzoquinone imine or NAPQI)

              Clearance: 0.27 L/hr/kg

              Protein binding: 10-25% (therapeutic concentrations); 8-43% (toxic concentrations)

              Excretion: <5% is excreted in the urine as unconjugated (free) acetaminophen and 60-80% as glucuronide metabolites

              Previous
              Next:

              Administration

              IV Incompatibilities

              Additive: chlorpromazine, diazepam

              Syringe: chlorpromazine, diazepam

              Y-site: chlorpromazine, diazepam

              IV Preparation

              1 gram dose: Insert a vented IV set through septum of the 100 mL vial; may be administered without further dilution

              Dose <1 gram: Using aseptic technique, withdraw the appropriate dose (650 mg or weight-based) from the intact sealed vial and place the measured dose in a separate empty, sterile container (eg, glass bottle, plastic IV container, or syringe) to avoid inadvertent delivery and administration of the total volume of the commercially available container

              Place small volume pediatric doses up to 60 mL in volume in a syringe and administer over 15 minutes

              Vial is for single use; discard any unused portion

              IV Administration

              Administer by IV infusion over 15 minutes

              Storage

              Store at room temperature 20-25°C (68-77°F); do not refrigerate or freeze

              For single use only; discard any unused portion

              Once the vacuum seal of the glass vial has been penetrated, or the contents transferred to another container, administer the dose within 6 hr

              Previous
              Next:

              Images

              BRAND FORM. UNIT PRICE PILL IMAGE
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              160 mg/5 mL (5 mL) solution
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              160 mg/5 mL liquid
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              650 mg tablet
              acetaminophen oral
              -
              650 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              160 mg/5 mL liquid
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              650 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              acetaminophen oral
              -
              500 mg tablet
              acetaminophen oral
              -
              80 mg tablet
              acetaminophen oral
              -
              325 mg tablet
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief (acetaminophen) oral
              -
              500 mg tablet
              Pain Relief (acetaminophen) oral
              -
              160 mg/5 mL liquid
              Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Pain Relief (acetaminophen) oral
              -
              160 mg/5 mL liquid
              Pain Reliever Extra Strength oral
              -
              500 mg tablet
              Pain Reliever Extra Strength oral
              -
              500 mg tablet
              Pain Reliever Extra Strength oral
              -
              500 mg tablet
              Pain Reliever Extra Strength oral
              -
              500 mg tablet
              Non-Aspirin Extra Strength oral
              -
              500 mg tablet
              Non-Aspirin Extra Strength oral
              -
              500 mg tablet
              Non-Aspirin Extra Strength oral
              -
              500 mg tablet
              Non-Aspirin Extra Strength oral
              -
              500 mg tablet
              Pain Relief Extra Strength oral
              -
              500 mg tablet
              Pain Relief Extra Strength oral
              -
              500 mg tablet
              Pain Relief Extra Strength oral
              -
              500 mg tablet
              Pain Relief Extra Strength oral
              -
              500 mg tablet
              Pain Relief Extra Strength oral
              -
              500 mg tablet
              Pain Relief Extra Strength oral
              -
              500 mg tablet
              Pain Relief Extra Strength oral
              -
              500 mg tablet
              Pain Reliever (acetaminophen) oral
              -
              325 mg tablet
              Pain Reliever (acetaminophen) oral
              -
              325 mg tablet
              Pain Reliever (acetaminophen) oral
              -
              500 mg tablet
              Pain Reliever (acetaminophen) oral
              -
              325 mg tablet
              Non-Aspirin oral
              -
              325 mg tablet
              Non-Aspirin oral
              -
              325 mg tablet
              Non-Aspirin oral
              -
              325 mg tablet
              Non-Aspirin oral
              -
              325 mg tablet
              Mapap (acetaminophen) oral
              -
              325 mg tablet
              Mapap (acetaminophen) oral
              -
              160 mg/5 mL liquid
              Mapap (acetaminophen) oral
              -
              500 mg capsule
              Mapap (acetaminophen) oral
              -
              160 mg/5 mL liquid
              PediaCare Fever Reducer oral
              -
              160 mg/5 mL suspension
              Pain Relief Adult oral
              -
              500 mg/15 mL liquid
              Children's Fever Reducing rectal
              -
              120 mg suppos
              Ofirmev intravenous
              -
              1,000 mg/100 mL (10 mg/mL) vial
              M-PAP oral
              -
              160 mg/5 mL liquid
              8HR Muscle Aches-Pain oral
              -
              650 mg tablet
              Infants' Pain Relief oral
              -
              160 mg/5 mL suspension
              Infants' Pain Relief oral
              -
              160 mg/5 mL suspension
              Tylenol 8 Hour oral
              -
              650 mg tablet
              Infants' Pain and Fever oral
              -
              160 mg/5 mL suspension
              Little Remedies Fever and Pain Reliever oral
              -
              160 mg/5 mL liquid
              Silapap oral
              -
              160 mg/5 mL liquid
              Silapap oral
              -
              160 mg/5 mL liquid
              Tylenol oral
              -
              325 mg tablet
              Tylenol oral
              -
              325 mg tablet
              Pharbetol oral
              -
              325 mg tablet
              Pharbetol oral
              -
              500 mg tablet
              Tylenol Arthritis Pain oral
              -
              650 mg tablet
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL liquid
              Children's Pain and Fever Relief oral
              -
              160 mg/5 mL liquid
              Children's Non-Aspirin oral
              -
              160 mg/5 mL suspension
              Children's Non-Aspirin oral
              -
              160 mg/5 mL suspension
              Children's Non-Aspirin oral
              -
              160 mg/5 mL suspension
              Arthritis Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Arthritis Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Arthritis Pain Relief (acetaminophen) oral
              -
              650 mg tablet
              Children's Acetaminophen oral
              -
              160 mg/5 mL suspension
              Children's Acetaminophen oral
              -
              32 mg/mL solution
              Children's Acetaminophen oral
              -
              160 mg/5 mL (5 mL) suspension
              Children's Acetaminophen oral
              -
              160 mg/5 mL suspension
              Children's Acetaminophen oral
              -
              160 mg/5 mL suspension
              Children's Acetaminophen oral
              -
              160 mg/5 mL suspension
              Children's Pain Relief oral
              -
              160 mg/5 mL suspension
              Children's Pain Relief oral
              -
              160 mg/5 mL suspension
              Children's Tylenol oral
              -
              160 mg chewable tablet
              Children's Tylenol oral
              -
              160 mg chewable tablet
              Children's Tylenol oral
              -
              160 mg/5 mL suspension
              Children's Tylenol oral
              -
              160 mg/5 mL suspension
              Infant's Tylenol oral
              -
              160 mg/5 mL suspension
              Tylenol Extra Strength oral
              -
              500 mg tablet
              8 Hour Pain Reliever oral
              -
              650 mg tablet
              8 Hour Pain Reliever oral
              -
              650 mg tablet
              Pain Relief Regular Strength oral
              -
              325 mg tablet
              Pain Relief Regular Strength oral
              -
              325 mg tablet
              Tactinal oral
              -
              325 mg tablet
              Mapap Arthritis Pain oral
              -
              650 mg tablet
              Mapap Arthritis Pain oral
              -
              650 mg tablet
              acetaminophen rectal
              -
              120 mg suppos
              acetaminophen rectal
              -
              120 mg suppos
              acetaminophen rectal
              -
              650 mg suppos
              acetaminophen rectal
              -
              650 mg suppos
              acetaminophen rectal
              -
              650 mg suppos
              Children's Mapap oral
              -
              80 mg chewable tablet
              Children's Mapap oral
              -
              80 mg chewable tablet
              Feverall rectal
              -
              80 mg suppos
              Feverall rectal
              -
              650 mg suppos
              Feverall rectal
              -
              325 mg suppos
              Feverall rectal
              -
              120 mg suppos
              Feverall rectal
              -
              80 mg suppos
              Feverall rectal
              -
              325 mg suppos
              Feverall rectal
              -
              120 mg suppos
              acetaminophen intravenous
              -
              1,000 mg/100 mL (10 mg/mL) vial
              acetaminophen intravenous
              -
              1,000 mg/100 mL (10 mg/mL) vial
              Acetaminophen Extra Strength oral
              -
              500 mg tablet
              Acetaminophen Extra Strength oral
              -
              500 mg tablet

              Copyright © 2010 First DataBank, Inc.

              Previous
              Next:

              Patient Handout

              Select a drug:
              Patient Education
              acetaminophen oral

              ACETAMINOPHEN - ORAL

              (a-SEET-a-MIN-oh-fen)

              COMMON BRAND NAME(S): Panadol, Tylenol

              WARNING: Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

              USES: This drug is used to treat mild to moderate pain (from headaches, menstrual periods, toothaches, backaches, osteoarthritis, or cold/flu aches and pains) and to reduce fever.

              HOW TO USE: Take this product by mouth as directed. Follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.There are many brands and forms of acetaminophen available. Read the dosing instructions carefully for each product because the amount of acetaminophen may be different between products. Do not take more acetaminophen than recommended. (See also Warning section.)If you are giving acetaminophen to a child, be sure you use a product that is meant for children. Use your child's weight to find the right dose on the product package. If you don't know your child's weight, you can use their age.For suspensions, shake the medication well before each dose. Some liquids do not need to be shaken before use. Follow all directions on the product package. Measure the liquid medication with the provided dose-measuring spoon/dropper/syringe to make sure you have the correct dose. Do not use a household spoon.For rapidly-dissolving tablets, chew or allow to dissolve on the tongue, then swallow with or without water. For chewable tablets, chew thoroughly before swallowing.Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.For effervescent tablets, dissolve the dose in the recommended amount of water, then drink.Pain medications work best if they are used as the first signs of pain occur. If you wait until the symptoms have worsened, the medication may not work as well.Do not take this medication for fever for more than 3 days unless directed by your doctor. For adults, do not take this product for pain for more than 10 days (5 days in children) unless directed by your doctor. If the child has a sore throat (especially with high fever, headache, or nausea/vomiting), consult the doctor promptly.Tell your doctor if your condition persists or worsens or if you develop new symptoms. If you think you may have a serious medical problem, get medical help right away.

              SIDE EFFECTS: See also Warning section.This drug usually has no side effects. If you have any unusual effects, contact your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

              PRECAUTIONS: See also Warning section.Before taking acetaminophen, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this product, tell your doctor or pharmacist your medical history, especially of: liver disease, regular use/abuse of alcohol.Liquid products, chewable tablets, or dissolving/effervescent tablets and powders may contain sugar or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. If you have any of these conditions, ask your doctor or pharmacist about using these products safely.Tell your doctor if you are pregnant before using this medication.Acetaminophen passes into breast milk. Consult your doctor before breast-feeding.

              DRUG INTERACTIONS: See also Warning section.Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.A product that may interact with this drug is: ketoconazole.This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

              OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, dark urine.

              NOTES: Acetaminophen does not cause the stomach and intestinal ulcers that NSAIDs such as aspirin, ibuprofen, and naproxen may cause. However, acetaminophen does not reduce swelling (inflammation) like the NSAIDs do. Consult your doctor for more details and to see which medication might be right for you.

              MISSED DOSE: If you are taking this medication on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

              STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

              Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

              IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

              Previous
              Next:

              Formulary

              FormularyPatient Discounts

              Adding plans allows you to compare formulary status to other drugs in the same class.

              To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

              Adding plans allows you to:

              • View the formulary and any restrictions for each plan.
              • Manage and view all your plans together – even plans in different states.
              • Compare formulary status to other drugs in the same class.
              • Access your plan list on any device – mobile or desktop.

              The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

              Tier Description
              1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
              2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
              3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
              4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
              NC NOT COVERED – Drugs that are not covered by the plan.
              Code Definition
              PA Prior Authorization
              Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
              QL Quantity Limits
              Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
              ST Step Therapy
              Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
              OR Other Restrictions
              Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
              Additional Offers
              Email to Patient

              From:

              To:

              The recipient will receive more details and instructions to access this offer.

              By clicking send, you acknowledge that you have permission to email the recipient with this information.

              Email Forms to Patient

              From:

              To:

              The recipient will receive more details and instructions to access this offer.

              By clicking send, you acknowledge that you have permission to email the recipient with this information.

              Previous
              Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.