olanzapine/samidorphan (Pending FDA Approval)

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Dosing & Uses

Schizophrenia

Pending FDA approval for schizophrenia

Bipolar 1 Disorder

Pending FDA approval for bipolar I disorder

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Pharmacology

Mechanism of Action

Olanzapine: May act through combination of dopamine and serotonin type 2 receptor site antagonism

Samidorphan: Opioid antagonist; mitigates weight gain associated with olanzapine

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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.