oliceridine (Rx)

>10%

Nausea (56-75%)

Vomiting (22-43%)

Dizziness (9-35%)

Hypoxia (5-20%

Somnolence (5-19%)

Pruritus (11-17%)

Constipation (11-17%)

Sedation (9-14%)

Back pain (11-13%)

1-10%

Decreased oxygen saturation (4-5%)

Contraindications

Significant respiratory depression

Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment

Known or suspected GI obstruction, including paralytic ileus

Known hypersensitivity (eg, anaphylaxis)

Cautions

Opioids expose users to risks of addiction, abuse, and misuse; assess patient risk

Serious life-threatening respiratory depression reported, even when used as recommended

Increased risk for life-threatening respiratory depression in patients with chronic pulmonary disease, geriatric patients, or those who are cachectic or debilitated

Prolonged use of opioids during pregnancy can result in withdrawal in the neonate; observe newborns for signs of neonatal opioid withdrawal syndrome and manage accordingly

QT prolongation may occur with doses exceeding 27 mg/day; if 27-mg cumulative daily dose reached and analgesia is still required, an alternative analgesic regimen should be administered until oliceridine can be resumed the next day

Cases of adrenal insufficiency reported with opioid use, more often following >1 month of use; symptoms may include nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood pressure; if adrenal insufficiency is diagnosed, treat with physiologic replacement doses of corticosteroids; wean patient off opioid to allow adrenal function to recover and continue corticosteroid treatment until adrenal function recovers; other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency

Avoid use in patients susceptible to carbon dioxide retention (eg, increased ICP, brain tumors, head injury, impaired consciousness, coma); oliceridine may reduce respiratory drive

May increase seizure frequency in patients with seizure disorders or in other clinical settings associated with seizures

Do not abruptly discontinue in patient physically dependent on opioids; abrupt discontinuation following prolonged therapy may lead to withdrawal symptoms; taper gradually

May impair mental or physical abilities to perform potentially hazardous actives (eg, driving, operating machinery)

Monitor patients on PCA for episodes of respiratory depression

GI conditions

• Contraindicated with known or suspected GI obstruction, including paralytic ileus
• Opioids may cause spasm of the sphincter of Oddi and may increase serum amylase
• Monitor patients with biliary tract disease, including acute pancreatitis, for worsening symptoms

Drug interaction overview

Opioids may reduce efficacy of diuretics by inducing release of antidiuretic hormone

Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus; monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics

Oliceridine may enhance neuromuscular blocking action of skeletal muscle relaxants and produce increased respiratory depression

• Benzodiazepines or other CNS depressants

  • Additive pharmacologic effect; increases risk of hypotension, respiratory depression, profound sedation, coma, and death
  • Reserve coadministration for patients whom alternative treatment options are inadequate; limit dosages and durations to minimum required
  • If decision is made to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analgesic, prescribe lowest effective dosages and minimum duration of concomitant use
  • If opioid analgesic initiated in a patient already taking a benzodiazepine or other CNS depressant, prescribe lower initial dose of opioid analgesic, and titrate based on clinical response
  • Coadministration with benzodiazepines or other CNS depressants (including alcohol) increases risk of adverse reactions, including overdose and death

• Moderate-to-strong CYP2D6 and/or CYP3A4 inhibitors

  • Caution; monitor closely for respiratory depression and sedation
  • If administered with both a CYP2D6 and CYP3A4 inhibitor, may require less frequent oliceridine dosing
  • Coadministration with moderate-to-strong CYP2D6 and/or CYP3A4 inhibitors can increase oliceridine plasma concentration, resulting in increased or prolonged opioid adverse reactions

• CYP3A4 inducers

  • Monitor for signs of opioid withdrawal
  • If coadministration with a CYP3A4 inducer is necessary, consider increasing oliceridine dose until stable drug effects are achieved
  • If a CYP3A4 inducer is discontinued, consider oliceridine dosage reduction and monitor for signs of respiratory depression

• Serotonergic drugs

  • Monitor if concomitant use is warranted; discontinue oliceridine if serotonin syndrome suspected
  • Opioids may enhance serotonergic effect of drugs (eg, SSRIs, SNRIs, MAOIs, TCAs, triptans, 5-HT3 antagonists, linezolid, IV methylene blue) that affect the serotonergic neurotransmitter system

• Mixed agonist/antagonist and partial agonist opioids

  • Avoid coadministration
  • May reduce oliceridine analgesic effects and/or precipitate withdrawal

Pregnancy

Prolonged use of opioid analgesics during pregnancy may result in neonatal opioid withdrawal syndrome

Animal studies

• Reduced live litter size at birth and increased postnatal pup mortality between birth and Postnatal Day 4 when oliceridine was administered IV to rats from organogenesis through weaning at doses producing clinically relevant plasma exposure
• Oliceridine had no effect on embryofetal development in rats and rabbits when administered IV during organogenesis at doses producing plasma exposures 7 and 8 times the estimated plasma exposure at the maximum recommended human dose

Clinical considerations

• Opioids cross the placenta and may produce respiratory depression and psychophysiologic effects in neonates
• Not recommended for use in pregnant females during and immediately prior to labor, when other analgesic techniques are more appropriate

Infertility

• Long-term opioid use may cause reduced fertility in females and males of reproductive potential
• Unknown whether these effects on fertility are reversible

Lactation

• Unknown if present in human milk
• Monitor infants exposed through breast milk for excess sedation and respiratory depression
• Withdrawal symptoms can occur in breastfed infants when maternal administration of an opioid analgesic is stopped or when breastfeeding is stopped

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Mu-opioid receptor agonist

Precise mechanism of action unknown; however, specific CNS opioid receptors for endogenous compounds with opioidlike activity have been identified throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug

Absorption

Onset of analgesia: 2-5 minutes (after initial dose)

Distribution

Protein bound: 77%

Vd: 90-120 L

Metabolism

Primarily metabolized to inactive metabolites by CYP3A4 and CYP2D6; minor contributions from CYP2C9 and CYP2C19

Elimination

Half-life: 1.3-3 hr; ~44 hr (metabolites)

Excretion: Urine ~70% (as metabolites), 0.97-6.75% (unchanged); remainder eliminated in feces

Pharmacogenomics

CYP2D6 poor metabolizers

• Approximately 3-10% of Whites, 2-7% of African Americans, and <2% of Asians generally lack the capacity to metabolize CYP2D6 substrates and are classified as poor metabolizers
• In healthy individuals who are CYP2D6 poor metabolizers, AUC was ~2-fold higher than in nonpoor CYP2D6 metabolizers

IV Preparation

Visually inspect parenteral drug products for particulate matter and discoloration before administration

Solution is a clear, colorless, preservative-free solution for IV use

If visibly opaque particles, discoloration, or other foreign particles are observed, do not use

IV Administration

For short-term IV use only in hospital or healthcare facility

Dose titration and maintenance

• Individually titrate dose to provide adequate analgesia and minimizes adverse reactions; continually reevaluate to assess the maintenance of pain relief
• If level of pain increases after dosage stabilization, attempt to identify the source of increased pain before increasing dosage
• If unacceptable opioid-related adverse reactions observed, consider reducing the dosage
• Adjust dosage to obtain appropriate balance between management of pain and opioid-related adverse reactions

Discontinuation

• Do not abruptly discontinue in physically dependent patient
• If patient shows signs of physical dependence, raise dose to previous level and taper more slowly, either by increasing interval between decreases, decreasing amount of dosage change, or both

Storage

Store at controlled room temperature 20-25ºC (68-77ºF); excursions permitted to 15-30ºC (59-86ºF)

Protect from freezing

Protect from light