arbaclofen (Pending FDA Approval)

Brand and Other Names:Ontinua ER
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Dosing & Uses

Spasticity

Pending FDA approval for treatment of spasticity in patients with multiple sclerosis (MS)

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Pharmacology

Mechanism of Action

Prodrug that is converted R-enantiomer of baclofen; allows for oral dosing with higher bioavailability

Inhibits synaptic transmission through spinal reflex arcs via hyperpolarization of primary afferent fiber terminals; this inhibition may decrease in muscle spasticity

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Images

No images available for this drug.
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Patient Handout

A Patient Handout is not currently available for this monograph.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.