opium tincture (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral liquid: Schedule II

  • 118mL/bottle
  • Each mL contains 10 mg of anhydrous morphine

Diarrhea

Indicated to treat diarrhea

6 mg (0.6 mL) PO q6hr; not to exceed 6 mL/day

Chronic Diarrhea (Orphan)

Orphan designation for treatment of chronic diarrhea in short bowel syndrome patients with an inadequate response to antidiarrheal treatment

Orphan sponsor

  • Marathon Pharmaceuticals, LLC; Nine Parkway Blvd North; Deerfield, IL 60015

Safety and efficacy not established

Next:

Interactions

Interaction Checker

and opium tincture

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            Contraindicated (1)

            • alvimopan

              alvimopan, opium tincture. receptor binding competition. Contraindicated. Contraindicated in opioid tolerant patients (ie, those who have taken therapeutic doses of opioids for >7 consecutive days immediately prior to taking alvimopan). Patients recently exposed to opioids are expected to be more sensitive to the effects of alvimopan and therefore may experience abdominal pain, nausea and vomiting, and diarrhea.

            Serious - Use Alternative (25)

            • buprenorphine

              buprenorphine, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

            • buprenorphine buccal

              buprenorphine buccal, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

            • butorphanol

              butorphanol, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

            • calcium/magnesium/potassium/sodium oxybates

              opium tincture, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

            • cimetidine

              cimetidine increases effects of opium tincture by decreasing metabolism. Avoid or Use Alternate Drug.

            • clonidine

              clonidine, opium tincture. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration enhances CNS depressant effects.

            • desvenlafaxine

              desvenlafaxine and opium tincture both increase serotonin levels. Avoid or Use Alternate Drug. May cause serotonin syndrome

            • eluxadoline

              opium tincture, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions. .

            • fentanyl

              fentanyl, opium tincture. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

            • fentanyl intranasal

              fentanyl intranasal, opium tincture. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

            • fentanyl transdermal

              fentanyl transdermal, opium tincture. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

            • fentanyl transmucosal

              fentanyl transmucosal, opium tincture. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

            • isocarboxazid

              isocarboxazid increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

            • linezolid

              linezolid increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

            • metoclopramide intranasal

              opium tincture, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

            • nalbuphine

              nalbuphine, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

            • pentazocine

              pentazocine, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.

            • phenelzine

              phenelzine increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

            • procarbazine

              procarbazine increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. MAOIs may potentiate CNS depression and hypotension. Do not use within 14 days of MAOI use. .

            • selegiline

              selegiline increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death.

            • selegiline transdermal

              selegiline transdermal increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death.

            • sodium oxybate

              opium tincture, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

            • tramadol

              tramadol, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Tramadol may reinitiate opiate dependence in pts. previously addicted to other opiates; it may also provoke withdrawal Sx. in pts. who are currently opiate dependent.

            • tranylcypromine

              tranylcypromine increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.

            • venlafaxine

              venlafaxine and opium tincture both increase serotonin levels. Avoid or Use Alternate Drug. May cause serotonin syndrome

            Monitor Closely (181)

            • albuterol

              opium tincture increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • alfentanil

              alfentanil and opium tincture both increase sedation. Use Caution/Monitor.

            • alprazolam

              alprazolam and opium tincture both increase sedation. Use Caution/Monitor.

            • amitriptyline

              opium tincture and amitriptyline both increase sedation. Use Caution/Monitor.

            • amobarbital

              amobarbital and opium tincture both increase sedation. Use Caution/Monitor.

            • amoxapine

              opium tincture and amoxapine both increase sedation. Use Caution/Monitor.

            • apomorphine

              opium tincture and apomorphine both increase sedation. Use Caution/Monitor.

            • arformoterol

              opium tincture increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • aripiprazole

              opium tincture and aripiprazole both increase sedation. Use Caution/Monitor.

            • armodafinil

              opium tincture increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • azelastine

              azelastine and opium tincture both increase sedation. Use Caution/Monitor.

            • baclofen

              baclofen and opium tincture both increase sedation. Use Caution/Monitor.

            • belladonna and opium

              belladonna and opium and opium tincture both increase sedation. Use Caution/Monitor.

            • benperidol

              opium tincture and benperidol both increase sedation. Use Caution/Monitor.

            • benzphetamine

              opium tincture increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • brexanolone

              brexanolone, opium tincture. Either increases toxicity of the other by sedation. Use Caution/Monitor.

            • brompheniramine

              brompheniramine and opium tincture both increase sedation. Use Caution/Monitor.

            • buprenorphine

              buprenorphine and opium tincture both increase sedation. Use Caution/Monitor.

            • buprenorphine buccal

              buprenorphine buccal and opium tincture both increase sedation. Use Caution/Monitor.

            • butabarbital

              butabarbital and opium tincture both increase sedation. Use Caution/Monitor.

            • butalbital

              butalbital and opium tincture both increase sedation. Use Caution/Monitor.

            • butorphanol

              butorphanol and opium tincture both increase sedation. Use Caution/Monitor.

            • caffeine

              opium tincture increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • carbinoxamine

              carbinoxamine and opium tincture both increase sedation. Use Caution/Monitor.

            • carisoprodol

              carisoprodol and opium tincture both increase sedation. Use Caution/Monitor.

            • cenobamate

              cenobamate, opium tincture. Either increases effects of the other by sedation. Use Caution/Monitor.

            • chloral hydrate

              chloral hydrate and opium tincture both increase sedation. Use Caution/Monitor.

            • chlordiazepoxide

              chlordiazepoxide and opium tincture both increase sedation. Use Caution/Monitor.

            • chlorpheniramine

              chlorpheniramine and opium tincture both increase sedation. Use Caution/Monitor.

            • chlorpromazine

              opium tincture and chlorpromazine both increase sedation. Use Caution/Monitor.

            • chlorzoxazone

              chlorzoxazone and opium tincture both increase sedation. Use Caution/Monitor.

            • cinnarizine

              cinnarizine and opium tincture both increase sedation. Use Caution/Monitor.

            • clemastine

              clemastine and opium tincture both increase sedation. Use Caution/Monitor.

            • clomipramine

              opium tincture and clomipramine both increase sedation. Use Caution/Monitor.

            • clonazepam

              clonazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • clorazepate

              clorazepate and opium tincture both increase sedation. Use Caution/Monitor.

            • clozapine

              opium tincture and clozapine both increase sedation. Use Caution/Monitor.

            • codeine

              codeine and opium tincture both increase sedation. Use Caution/Monitor.

            • cyclizine

              cyclizine and opium tincture both increase sedation. Use Caution/Monitor.

            • cyclobenzaprine

              cyclobenzaprine and opium tincture both increase sedation. Use Caution/Monitor.

            • cyproheptadine

              cyproheptadine and opium tincture both increase sedation. Use Caution/Monitor.

            • dantrolene

              dantrolene and opium tincture both increase sedation. Use Caution/Monitor.

            • desflurane

              desflurane and opium tincture both increase sedation. Use Caution/Monitor. Opioids may decrease MAC requirements, less inhalation anesthetic may be required.

            • desipramine

              opium tincture and desipramine both increase sedation. Use Caution/Monitor.

            • dexchlorpheniramine

              dexchlorpheniramine and opium tincture both increase sedation. Use Caution/Monitor.

            • dexfenfluramine

              opium tincture increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dexmedetomidine

              dexmedetomidine and opium tincture both increase sedation. Use Caution/Monitor.

            • dexmethylphenidate

              opium tincture increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dextroamphetamine

              opium tincture increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dextromoramide

              dextromoramide and opium tincture both increase sedation. Use Caution/Monitor.

            • diamorphine

              diamorphine and opium tincture both increase sedation. Use Caution/Monitor.

            • diazepam

              diazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • diethylpropion

              opium tincture increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • difenoxin hcl

              difenoxin hcl and opium tincture both increase sedation. Use Caution/Monitor.

            • dimenhydrinate

              dimenhydrinate and opium tincture both increase sedation. Use Caution/Monitor.

            • diphenhydramine

              diphenhydramine and opium tincture both increase sedation. Use Caution/Monitor.

            • diphenoxylate hcl

              diphenoxylate hcl and opium tincture both increase sedation. Use Caution/Monitor.

            • dipipanone

              dipipanone and opium tincture both increase sedation. Use Caution/Monitor.

            • dobutamine

              opium tincture increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dopamine

              opium tincture increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dopexamine

              opium tincture increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • dosulepin

              opium tincture and dosulepin both increase sedation. Use Caution/Monitor.

            • doxepin

              opium tincture and doxepin both increase sedation. Use Caution/Monitor.

            • doxylamine

              doxylamine and opium tincture both increase sedation. Use Caution/Monitor.

            • droperidol

              opium tincture and droperidol both increase sedation. Use Caution/Monitor.

            • eltrombopag

              eltrombopag increases levels of opium tincture by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.

            • ephedrine

              opium tincture increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • epinephrine

              opium tincture increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • epinephrine racemic

              opium tincture increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • estazolam

              estazolam and opium tincture both increase sedation. Use Caution/Monitor.

            • ethanol

              opium tincture and ethanol both increase sedation. Use Caution/Monitor.

            • etomidate

              etomidate and opium tincture both increase sedation. Use Caution/Monitor.

            • fenfluramine

              opium tincture increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • fluphenazine

              opium tincture and fluphenazine both increase sedation. Use Caution/Monitor.

            • flurazepam

              flurazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • formoterol

              opium tincture increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • haloperidol

              opium tincture and haloperidol both increase sedation. Use Caution/Monitor.

            • hydromorphone

              hydromorphone and opium tincture both increase sedation. Use Caution/Monitor.

            • hydroxyzine

              hydroxyzine and opium tincture both increase sedation. Use Caution/Monitor.

            • iloperidone

              opium tincture and iloperidone both increase sedation. Use Caution/Monitor.

            • imipramine

              opium tincture and imipramine both increase sedation. Use Caution/Monitor.

            • isocarboxazid

              opium tincture, isocarboxazid. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.

            • isoproterenol

              opium tincture increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • ketamine

              ketamine and opium tincture both increase sedation. Use Caution/Monitor.

            • ketotifen, ophthalmic

              opium tincture and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

            • lasmiditan

              lasmiditan, opium tincture. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

            • lemborexant

              lemborexant, opium tincture. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

            • levalbuterol

              opium tincture increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • levorphanol

              levorphanol and opium tincture both increase sedation. Use Caution/Monitor.

            • linezolid

              opium tincture, linezolid. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.

            • lisdexamfetamine

              opium tincture increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • lofepramine

              opium tincture and lofepramine both increase sedation. Use Caution/Monitor.

            • lofexidine

              opium tincture and lofexidine both increase sedation. Use Caution/Monitor.

            • loprazolam

              loprazolam and opium tincture both increase sedation. Use Caution/Monitor.

            • lorazepam

              lorazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • lormetazepam

              lormetazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • loxapine

              opium tincture and loxapine both increase sedation. Use Caution/Monitor.

            • loxapine inhaled

              opium tincture and loxapine inhaled both increase sedation. Use Caution/Monitor.

            • lurasidone

              lurasidone, opium tincture. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.

            • maprotiline

              opium tincture and maprotiline both increase sedation. Use Caution/Monitor.

            • marijuana

              opium tincture and marijuana both increase sedation. Use Caution/Monitor.

            • melatonin

              opium tincture and melatonin both increase sedation. Use Caution/Monitor.

            • meperidine

              meperidine and opium tincture both increase sedation. Use Caution/Monitor.

            • meprobamate

              opium tincture and meprobamate both increase sedation. Use Caution/Monitor.

            • metaproterenol

              opium tincture increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • metaxalone

              metaxalone and opium tincture both increase sedation. Use Caution/Monitor.

            • methadone

              methadone and opium tincture both increase sedation. Use Caution/Monitor.

            • methamphetamine

              opium tincture increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • methocarbamol

              methocarbamol and opium tincture both increase sedation. Use Caution/Monitor.

            • methylenedioxymethamphetamine

              opium tincture increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • midazolam

              midazolam and opium tincture both increase sedation. Use Caution/Monitor.

            • midazolam intranasal

              midazolam intranasal, opium tincture. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

            • midodrine

              opium tincture increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • mirtazapine

              opium tincture and mirtazapine both increase sedation. Use Caution/Monitor.

            • modafinil

              opium tincture increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • morphine

              morphine and opium tincture both increase sedation. Use Caution/Monitor.

            • motherwort

              opium tincture and motherwort both increase sedation. Use Caution/Monitor.

            • moxonidine

              opium tincture and moxonidine both increase sedation. Use Caution/Monitor.

            • nabilone

              opium tincture and nabilone both increase sedation. Use Caution/Monitor.

            • nalbuphine

              nalbuphine and opium tincture both increase sedation. Use Caution/Monitor.

            • norepinephrine

              opium tincture increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • nortriptyline

              opium tincture and nortriptyline both increase sedation. Use Caution/Monitor.

            • olanzapine

              opium tincture and olanzapine both increase sedation. Use Caution/Monitor.

            • orphenadrine

              orphenadrine and opium tincture both increase sedation. Use Caution/Monitor.

            • oxazepam

              oxazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • oxycodone

              opium tincture and oxycodone both increase sedation. Use Caution/Monitor.

            • oxymorphone

              opium tincture and oxymorphone both increase sedation. Use Caution/Monitor.

            • paliperidone

              opium tincture and paliperidone both increase sedation. Use Caution/Monitor.

            • papaveretum

              opium tincture and papaveretum both increase sedation. Use Caution/Monitor.

            • papaverine

              opium tincture and papaverine both increase sedation. Use Caution/Monitor.

            • pegvisomant

              opium tincture decreases effects of pegvisomant by unknown mechanism. Use Caution/Monitor.

            • pentazocine

              opium tincture and pentazocine both increase sedation. Use Caution/Monitor.

            • pentobarbital

              pentobarbital and opium tincture both increase sedation. Use Caution/Monitor.

            • perphenazine

              opium tincture and perphenazine both increase sedation. Use Caution/Monitor.

            • phendimetrazine

              opium tincture increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • phenelzine

              opium tincture, phenelzine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.

            • phenobarbital

              phenobarbital and opium tincture both increase sedation. Use Caution/Monitor.

            • phentermine

              opium tincture increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • phenylephrine

              opium tincture increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • phenylephrine PO

              opium tincture increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

            • pholcodine

              opium tincture and pholcodine both increase sedation. Use Caution/Monitor.

            • pimozide

              opium tincture and pimozide both increase sedation. Use Caution/Monitor.

            • pirbuterol

              opium tincture increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • primidone

              primidone and opium tincture both increase sedation. Use Caution/Monitor.

            • prochlorperazine

              opium tincture and prochlorperazine both increase sedation. Use Caution/Monitor.

            • promethazine

              promethazine and opium tincture both increase sedation. Use Caution/Monitor.

            • propofol

              propofol and opium tincture both increase sedation. Use Caution/Monitor.

            • propylhexedrine

              opium tincture increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • protriptyline

              opium tincture and protriptyline both increase sedation. Use Caution/Monitor.

            • quazepam

              quazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • quetiapine

              opium tincture and quetiapine both increase sedation. Use Caution/Monitor.

            • ramelteon

              opium tincture and ramelteon both increase sedation. Use Caution/Monitor.

            • rasagiline

              rasagiline increases toxicity of opium tincture by unknown mechanism. Use Caution/Monitor. Risk of hypotension, hyperpyrexia, somnolence, or death.

            • risperidone

              opium tincture and risperidone both increase sedation. Use Caution/Monitor.

            • salmeterol

              opium tincture increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • scullcap

              opium tincture and scullcap both increase sedation. Use Caution/Monitor.

            • secobarbital

              secobarbital and opium tincture both increase sedation. Use Caution/Monitor.

            • selegiline transdermal

              opium tincture, selegiline transdermal. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.

            • sevoflurane

              sevoflurane and opium tincture both increase sedation. Use Caution/Monitor.

            • shepherd's purse

              opium tincture and shepherd's purse both increase sedation. Use Caution/Monitor.

            • stiripentol

              stiripentol, opium tincture. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

            • sufentanil

              opium tincture and sufentanil both increase sedation. Use Caution/Monitor.

            • tapentadol

              opium tincture and tapentadol both increase sedation. Use Caution/Monitor.

            • temazepam

              temazepam and opium tincture both increase sedation. Use Caution/Monitor.

            • terbutaline

              opium tincture increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • thioridazine

              opium tincture and thioridazine both increase sedation. Use Caution/Monitor.

            • thiothixene

              opium tincture and thiothixene both increase sedation. Use Caution/Monitor.

            • topiramate

              opium tincture and topiramate both increase sedation. Modify Therapy/Monitor Closely.

            • tramadol

              opium tincture and tramadol both increase sedation. Use Caution/Monitor.

            • tranylcypromine

              opium tincture, tranylcypromine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.

            • trazodone

              opium tincture and trazodone both increase sedation. Use Caution/Monitor.

            • triazolam

              triazolam and opium tincture both increase sedation. Use Caution/Monitor.

            • triclofos

              triclofos and opium tincture both increase sedation. Use Caution/Monitor.

            • trifluoperazine

              opium tincture and trifluoperazine both increase sedation. Use Caution/Monitor.

            • trimipramine

              opium tincture and trimipramine both increase sedation. Use Caution/Monitor.

            • triprolidine

              triprolidine and opium tincture both increase sedation. Use Caution/Monitor.

            • xylometazoline

              opium tincture increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • yohimbine

              opium tincture increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

            • ziconotide

              opium tincture and ziconotide both increase sedation. Use Caution/Monitor.

            • ziprasidone

              opium tincture and ziprasidone both increase sedation. Use Caution/Monitor.

            • zotepine

              opium tincture and zotepine both increase sedation. Use Caution/Monitor.

            Minor (7)

            • brimonidine

              brimonidine increases effects of opium tincture by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.

            • dextroamphetamine

              dextroamphetamine increases effects of opium tincture by unspecified interaction mechanism. Minor/Significance Unknown.

            • eucalyptus

              opium tincture and eucalyptus both increase sedation. Minor/Significance Unknown.

            • lidocaine

              lidocaine increases toxicity of opium tincture by pharmacodynamic synergism. Minor/Significance Unknown. Risk of increased CNS depression.

            • rifampin

              rifampin decreases levels of opium tincture by increasing metabolism. Minor/Significance Unknown.

            • sage

              opium tincture and sage both increase sedation. Minor/Significance Unknown.

            • ziconotide

              ziconotide, opium tincture. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Additive decreased GI motility. Additive analgesia. Ziconotide does NOT potentiate opioid induced respiratory depression.

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            Adverse Effects

            Frequency Not Defined

            Constipation

            Nausea

            Vomiting

            Pruritus

            Urticaria

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            Warnings

            Contraindications

            Hypersensitivity

            Respiratory disease/depression, diarrhea due to poison, pseudomembranous colitis, glaucoma, severe hepatic disease, convulsive disorders

            Cautions

            Caution in asthma, severe prostatic hypertrophy, thyroid dysfunction, hepatic disease, history of opioid dependence, patients morbidly obese, and concurrent CNS depressants

            Caution in patients with head trauma

            Opium tincture contains 25 times more morphine than paregoric & should never be confused with the latter

            Caution in patients with acute adrenal insufficiency (eg, Addison's disease)

            Caution in patients with biliary tract dysfunction

            Caution in patients with GI hemorrhage

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            Pregnancy & Lactation

            Pregnancy

            Unknown whether drug may cause fetal harm when administered to pregnant females or can affect reproduction capacity

            No animal studies conducted

            Lactation

            Exercise caution when administering to nursing females

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Opium, because of its morphine content, inhibits GI motility and propulsion, diminishes digestive secretion; increases GI muscle tone

            Absorption

            Well absorbed from the gastrointestinal tract

            Metabolism

            Extensively metabolized in liver, undergoes conjugation with glucuronic acid

            Metabolites: Morphine-3-glucuronide, morphine-3-6-diglucuronide

            Elimination

            Excretion: Urine (~75% [unchanged])

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            Administration

            Oral Administration

            May take with or without food

            Storage

            Store 20-25ºC (68-77ºF)

            Protect from light

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            Images

            BRAND FORM. UNIT PRICE PILL IMAGE
            opium tincture oral
            -
            10 mg/mL (morphine) liquid

            Copyright © 2010 First DataBank, Inc.

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            Patient Handout

            Patient Education
            opium tincture oral

            OPIUM TINCTURE - ORAL

            (OH-pee-um)

            USES: This medication is used to treat diarrhea. It helps to decrease how often you have bowel movements. It works by slowing the movement of the intestines. Opium belongs to a class of drugs known as opioid pain relievers, but this medication acts mainly to slow the gut.

            HOW TO USE: Take this medication by mouth as directed by your doctor, usually 4 times daily. It may be taken with food or meals if stomach upset occurs.Carefully measure each dose using the dropper provided. If your medication comes in an oral dosing syringe, use the syringe to measure the dose. Do not use a household spoon because you may not get the correct dose. Do not inject the medication. The dose may be mixed with a small amount of water just before taking.The dosage is based on your medical condition and response to treatment.If you suddenly stop using this medication, you may have withdrawal symptoms (such as sweating, nausea, vomiting, restlessness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used opium for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Do not increase your dose, take it more often, or use it for a longer time than prescribed. Properly stop the medication when so directed.When used for a long time, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.Diarrhea can sometimes cause dehydration. It is important that you drink the proper amount of fluids and electrolytes to prevent this effect. Tell your doctor right away if you develop signs of dehydration (such as unusual decreased urination, unusual dry mouth/thirst, fast heartbeat, or dizziness/lightheadedness). You may also need to change to a bland diet during this time to reduce irritation to your stomach/intestines. Consult your doctor or pharmacist for more information.Tell your doctor if your condition lasts or gets worse after 2 to 3 days of treatment.

            SIDE EFFECTS: Nausea, vomiting, lightheadedness, dizziness, drowsiness, or constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as agitation, confusion, hallucinations), severe stomach/abdominal pain, difficulty urinating.Get medical help right away if you have any very serious side effects, including: fainting, seizure, slow/shallow breathing, severe drowsiness/difficulty waking up.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

            PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other opioids (such as codeine, morphine); or to papaverine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Since this medication slows the gut, it should not be used to treat diarrhea caused by poisoning until the toxin is removed from your gut.Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), kidney disease, liver disease, mental/mood disorders (such as confusion, depression), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), difficulty urinating (such as due to enlarged prostate), disease of the pancreas (pancreatitis), gallbladder disease.This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).This product also contains alcohol. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid alcohol in your diet. Ask your doctor or pharmacist about using this product safely.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Children may be more sensitive to the side effects of this drug, especially slow/shallow breathing.Older adults may be more sensitive to side effects of this drug, especially slow/shallow breathing and drowsiness.Before using this medication, women of childbearing age should talk with their doctor(s) about the risks and benefits. Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It may slightly increase the risk of birth defects if used during the first two months of pregnancy. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, take the smallest effective dose for the shortest possible time. Tell the doctor right away if you notice any symptoms in your newborn baby such as slow/shallow breathing, irritability, crying that is unusual or doesn't stop, vomiting, or diarrhea.This drug passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding.

            DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: certain pain medications (mixed opioid agonist/antagonists such as pentazocine, nalbuphine, butorphanol), naltrexone.The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

            OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slowed breathing, slow heartbeat, severe dizziness/drowsiness, fainting, muscle weakness.

            NOTES: Do not share this medication with others. Sharing it is against the law.

            MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

            STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

            Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

            IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.