metipranolol ophthalmic (Discontinued)

Brand and Other Names:OptiPranolol (DSC)
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.3%

Open-Angle Glaucoma

1 gtt in affected eye(s) q12hr

Safety & efficacy not established

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Interactions

Interaction Checker

and metipranolol ophthalmic

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    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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             activity indicator 

            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (2)

                • digoxin

                  metipranolol ophthalmic increases effects of digoxin by pharmacodynamic synergism. Use Caution/Monitor.

                • fingolimod

                  metipranolol ophthalmic increases effects of fingolimod by pharmacodynamic synergism. Use Caution/Monitor. Both medications decrease heart rate. Monitor patients on concomitant therapy, particularly in the first 6 hours after fingolimod is initiated or after a treatment interruption of at least two weeks, for bradycardia and atrioventricular block. To identify underlying risk factors of bradycardia and AV block, obtain a new or recent ECG in patients using beta-blockers prior to starting fingolimod.

                Minor (25)

                • acebutolol

                  metipranolol ophthalmic increases effects of acebutolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • amlodipine

                  metipranolol ophthalmic increases effects of amlodipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • atenolol

                  metipranolol ophthalmic increases effects of atenolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • betaxolol

                  metipranolol ophthalmic increases effects of betaxolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • bisoprolol

                  metipranolol ophthalmic increases effects of bisoprolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • carvedilol

                  metipranolol ophthalmic increases effects of carvedilol by pharmacodynamic synergism. Minor/Significance Unknown.

                • celiprolol

                  metipranolol ophthalmic increases effects of celiprolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • clevidipine

                  metipranolol ophthalmic increases effects of clevidipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • diltiazem

                  metipranolol ophthalmic increases effects of diltiazem by pharmacodynamic synergism. Minor/Significance Unknown.

                • esmolol

                  metipranolol ophthalmic increases effects of esmolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • felodipine

                  metipranolol ophthalmic increases effects of felodipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • isradipine

                  metipranolol ophthalmic increases effects of isradipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • labetalol

                  metipranolol ophthalmic increases effects of labetalol by pharmacodynamic synergism. Minor/Significance Unknown.

                • metoprolol

                  metipranolol ophthalmic increases effects of metoprolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • nadolol

                  metipranolol ophthalmic increases effects of nadolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • nebivolol

                  metipranolol ophthalmic increases effects of nebivolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • nicardipine

                  metipranolol ophthalmic increases effects of nicardipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • nifedipine

                  metipranolol ophthalmic increases effects of nifedipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • nisoldipine

                  metipranolol ophthalmic increases effects of nisoldipine by pharmacodynamic synergism. Minor/Significance Unknown.

                • penbutolol

                  metipranolol ophthalmic increases effects of penbutolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • pindolol

                  metipranolol ophthalmic increases effects of pindolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • propranolol

                  metipranolol ophthalmic increases effects of propranolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • sotalol

                  metipranolol ophthalmic increases effects of sotalol by pharmacodynamic synergism. Minor/Significance Unknown.

                • timolol

                  metipranolol ophthalmic increases effects of timolol by pharmacodynamic synergism. Minor/Significance Unknown.

                • verapamil

                  metipranolol ophthalmic increases effects of verapamil by pharmacodynamic synergism. Minor/Significance Unknown.

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                Adverse Effects

                Frequency Not Defined

                Ocular

                • Burning sensation in eye
                • Blepharitis
                • Blurred vision
                • Light intolerance
                • Uveitis
                • Tearing
                • Eyelid dermatitis
                • Browache

                Systemic

                • Similar to systemic beta-blockers including bradycardia, aggravation of CHF, nausea, asthma, nightmares, impotence, tiredness, cough, dyspnea, epistaxis, rhinitis, myalgia, arthritis, rash
                • Reduction of systemic side effects by putting finger in corner of eye (occluding punctum) or by gentle eyelid closure (without opening & closing lid) for 3 min
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                Warnings

                Contraindications

                Hypersensitivity

                Asthma, uncompensated CHF, severe COPD, symptomatic sinus bradycardia, 2nd or 3rd degree AV block, cardiogenic shock

                Cautions

                Caution in diabetes (may mask signs of hypoglycemia)

                Caution on inadequate cardiac function, latent cardiac insufficiency, cerebrovascular insufficiency, sick sinus syndrome, peripheral vascular disease, history of psychiatric illness, heart failure, diminished pulmonary function, nonallergic bronchospasm, diabetes mellitus, myasthenia gravis

                Patients receiving topical levobunolol & a systemic ß-adrenergic blocking agent concomitantly should be observed carefully for potential additive effects on IOP &/or systemic effects of ß-adrenergic blockade

                May mask signs of hyperthyroidism (ie, tachycardia)

                Remove contact lens prior to administration

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                Pregnancy & Lactation

                Pregnancy Category: C

                Lactation: Excretion in breast milk unknown; use caution

                Pregnancy Categories

                A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                NA: Information not available.

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                Pharmacology

                Mechanism of Action

                Nonselective beta-adrenergic receptor blocker; lacks intrinsic sympathomimetic activity and membrane stabilizing effects; reduces IOP by reducing production of aqueous humor

                Pharmacokinetics

                Onset of action: <30 min

                Peak effect: ~2 hr

                Half-life: 3 hr

                Duration: Up to 24 hr (intraocular pressure reduction)

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                Images

                BRAND FORM. UNIT PRICE PILL IMAGE
                metipranolol ophthalmic (eye)
                -
                0.3 % drops

                Copyright © 2010 First DataBank, Inc.

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                Patient Handout

                Patient Education
                metipranolol ophthalmic (eye)

                METIPRANOLOL - OPHTHALMIC

                (met-eh-PRAN-oh-lol)

                COMMON BRAND NAME(S): Optipranolol

                USES: This medication is used alone or with other medications to treat high pressure inside the eye due to glaucoma (open-angle type) or other eye diseases (e.g., ocular hypertension). Lowering high pressure inside the eye helps to prevent blindness. Metipranolol belongs to a class of drugs known as beta blockers and works by decreasing the amount of fluid production within the eye.

                HOW TO USE: To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.If you are wearing contact lenses, remove them before using eye drops. Wait at least 15 minutes before replacing your contact lenses.Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch, usually twice daily or as directed by your doctor. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed.Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 to 10 minutes before using the other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. Keep using this medication even if you feel well. Most people with glaucoma or high pressure in the eyes do not feel sick.

                SIDE EFFECTS: Temporary discomfort of the eye, blurred vision, watery eyes, headache, drowsiness, or dizziness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these unlikely but serious side effects occur: eye pain/swelling/discharge, increased eye sensitivity to light, vision changes, slow/irregular heartbeat, muscle weakness, mental/mood changes, tiredness, swelling of the ankles/feet, sudden/unexplained weight gain.Seek immediate medical attention if any of these rare but very serious side effects occur: trouble breathing, chest/jaw/left arm pain, weakness on one side of the body, trouble speaking, confusion.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                PRECAUTIONS: Before using metipranolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers (e.g., timolol, levobunolol); or if you have any other allergies. This product may contain inactive ingredients (such as preservatives like benzalkonium chloride), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problems (e.g., asthma or a history of asthma, chronic obstructive pulmonary disease-COPD), certain types of heart rhythm problems (e.g., sinus bradycardia, second- or third-degree atrioventricular block), certain serious heart conditions (e.g., cardiogenic shock, severe heart failure).Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., bronchitis, emphysema), diabetes, heart failure (treated, stable type), blood circulation problems (e.g., cerebrovascular insufficiency), overactive thyroid (hyperthyroidism), muscle weakness disorders (e.g., myasthenia gravis).Before having surgery, tell your doctor or dentist that you are using this medication.This drug may make you dizzy or drowsy or blur your vision. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).If you have diabetes, this product may mask the fast/pounding heartbeat you would usually feel when your blood sugar level falls too low (hypoglycemia). Other symptoms of a low blood sugar level, such as dizziness/sweating, are unaffected by this drug.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

                DRUG INTERACTIONS: Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: digoxin, drugs for high blood pressure (including clonidine, oral beta blockers such as propranolol, calcium channel blockers such as diltiazem), epinephrine, fingolimod.This document does not contain all possible interactions. Before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

                OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. If this product is accidentally swallowed, you may experience symptoms such as trouble breathing, slow/irregular heartbeat.

                NOTES: Do not share this medication with others.Laboratory and/or medical tests (e.g., eye exams) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

                MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

                STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

                IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.