azelastine ophthalmic (Rx)

Brand and Other Names:Optivar
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

ophthalmic solution

  • 0.05%

Allergic Conjunctivitis

Instill 1 gtt in affected eye(s) q12hr

Dosage Forms & Strengths

ophthalmic solution

  • 0.05%

Allergic Conjunctivitis

<3 years: Safety and efficacy not established

>3 years: As adults; instill 1 gtt in affected eye(s) q12hr

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Adverse Effects

>10%

Transient burning/stinging (30%)

Headache (15%)

Bitter taste (10%)

Frequency Not Defined

Asthma

Temporary blurring

Bitter taste

Conjunctivitis

Dyspnea

Eye pain

Fatigue

Influenza-like symptoms

Pharyngitis

Pruritus

Rhinitis

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Warnings

Contraindications

Hypersensitivity

Contact lens-related irritation

Cautions

Do not wear contact lenses if eyes are red; wait 10 min after azelastine to insert contacts

Take care not to touch any surface, the eyelids, or surrounding areas with the dropper tip of the bottle or single-use container to prevent contaminating the dropper tip and solution; discard single-use container immediately after use; product is sterile when packaged

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Pregnancy & Lactation

Pregnancy Category: C

Lactation: Excretion in milk unknown; use with caution

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Histamine H1 antagonist, inhibits vascular permeability and release of histamine and other mediators involved in allergic response

Pharmacokinetics

Half-Life: 22 hr

Onset of action: 3 min (peak effect)

Duration: 8 hr

Absorption: Extremely low systemic exposure

Protein Bound: 88-97%

Metabolism: Liver

Excretion: Feces

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Images

BRAND FORM. UNIT PRICE PILL IMAGE
azelastine ophthalmic (eye)
-
0.05 % drops
azelastine ophthalmic (eye)
-
0.05 % drops
azelastine ophthalmic (eye)
-
0.05 % drops
azelastine ophthalmic (eye)
-
0.05 % drops
azelastine nasal
-
205.5 mcg (0.15 %) aerosol
azelastine nasal
-
137 mcg (0.1 %) aerosol
azelastine nasal
-
205.5 mcg (0.15 %) aerosol
azelastine nasal
-
205.5 mcg (0.15 %) aerosol
azelastine nasal
-
137 mcg (0.1 %) aerosol
azelastine nasal
-
137 mcg (0.1 %) aerosol
azelastine nasal
-
137 mcg (0.1 %) aerosol
azelastine nasal
-
137 mcg (0.1 %) aerosol
azelastine nasal
-
137 mcg (0.1 %) aerosol
azelastine nasal
-
205.5 mcg (0.15 %) aerosol
azelastine nasal
-
137 mcg (0.1 %) aerosol
azelastine nasal
-
205.5 mcg (0.15 %) aerosol

Copyright © 2010 First DataBank, Inc.

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Patient Handout

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Patient Education
azelastine ophthalmic (eye)

AZELASTINE DROPS - OPHTHALMIC

(AY-ze-LAS-teen)

COMMON BRAND NAME(S): Optivar

USES: This medication is used to treat itching eyes caused by allergies (allergic conjunctivitis). Azelastine belongs to a class of drugs known as antihistamines. It works by blocking certain natural substances called histamines that are responsible for allergic symptoms.Do not use this medication to treat redness and irritation due to wearing contact lenses.

HOW TO USE: Use this medication in the affected eye(s) as directed by your doctor, usually twice daily.To apply eye drops, wash hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.If you are wearing contact lenses, remove them before using eye drops. Wait at least 10 minutes before replacing your contact lenses. Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward, gently close your eyes, and place one finger at the corner of your eye (near the nose). Apply gentle pressure for 1 to 2 minutes before opening your eyes. This will prevent the medication from draining out. Try not to blink or rub your eye. Repeat these steps if your dose is for more than one drop. If directed to use this medication in both eyes, repeat these steps for your other eye. Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (such as drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day.Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.Tell your doctor if you do not get better or if you get worse.

SIDE EFFECTS: This medication may temporarily sting or burn your eyes for a minute or two after use. Temporary blurred vision, headache, or a bitter taste in your mouth may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: eye pain.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

PRECAUTIONS: Before using azelastine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

NOTES: Do not share this medication with others.Ask your doctor for ways to reduce your exposure to substances (such as pollen, pet dander, dust mites, mold, smoke) that can worsen allergy symptoms.

MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

STORAGE: Keep the bottle upright and tightly closed. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
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Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
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Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.