orphenadrine/aspirin/caffeine (Rx)

Brand and Other Names:Orphengesic Forte
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

orphenadrine/aspirin/caffeine

tablet

  • 50mg/770mg/60mg

Musculoskeletal Pain

Indicated for symptomatic relief of mild-to-moderate pain caused by acute musculoskeletal disorders as an adjunct to rest, physical therapy, and other measures

0.5-1 tablet (25mg/385mg/30mg to 50mg/770mg/60mg) PO TID/QID

Dosage Forms & Strengths

orphenadrine/aspirin/caffeine

tablet

  • 50mg/770mg/60mg

Musculoskeletal Pain

Indicated for symptomatic relief of mild-to-moderate pain caused by acute musculoskeletal disorders as an adjunct to rest, physical therapy, and other measures

<12 years: Safety and efficacy not established

≥12 years: 0.5-1 tablet (25mg/385mg/30mg to 50mg/770mg/60mg) PO TID/QID

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Interactions

Interaction Checker

and orphenadrine/aspirin/caffeine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Tachycardia

            Palpitation

            Urinary hesitancy or retention

            Dry mouth

            Blurred vision

            Dilated pupils

            Increased intraocular tension

            Weakness

            Nausea

            Vomiting

            Headache

            Dizziness

            Constipation

            Drowsiness

            Urticaria (rare)

            Other dermatosis (rare)

            Confusion in elderly individuals (infrequent)

            Mild central excitation and occasional hallucinations

            Aplastic anemia (single case)

            Gastrointestinal hemorrhage (rare)

            Transient episodes of light-headedness, dizziness, or syncope

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            Warnings

            Contraindications

            Glaucoma

            Pyloric or duodenal obstruction

            Achalasia

            Prostatic hypertrophy or bladder neck obstructions

            Myasthenia gravis

            Hypersensitivity to orphenadrine, aspirin, or caffeine

            Cautions

            Not recommended for use in patients with chicken pox, influenza, or flu symptoms; Reye syndrome may develop in individuals who have chicken pox, influenza, or flu symptoms; studies suggest association between Reye syndrome and use of medicines containing salicylate or aspirin

            May impair patient’s ability to engage in potentially hazardous activities (eg, operating machinery, driving a motor vehicle)

            Aspirin should be used with extreme caution in the presence of peptic ulcers and coagulation abnormalities

            Safety of continuous long term therapy has not been established; therefore, if prescribed for prolonged use, periodic monitoring recommended of blood, urine, and liver function values

            Mild adverse effects may respond to dose reduction

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            Pregnancy & Lactation

            Pregnancy

            Safety during pregnancy has not been established

            Lactation

            Safety during lactation has not been established

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Orphenadrine: Indirect skeletal muscle relaxant; exact mechanism unknown, but may antagonize N-methyl-D-aspartate (NMDA) receptors

            Aspirin: Inhibits synthesis of prostaglandin by cyclooxygenase; has antiinflammatory and analgesic activity

            Caffeine: Mild, direct stimulant effect of the CNS, heart, and cardiovascular system; stimulates the respiratory center of the medulla

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            Administration

            Oral Administration

            May take with or without food

            Storage

            Store below 30ºC (86ºF)

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            Images

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.