Dosing & Uses
Dosage Forms & Strengths
lotion
- 0.5%
Head Lice
Hair: Apply to dry hair, leave in 8-12 hours
May repeat if lice are present after 7-9 days
Dosage Forms & Strengths
lotion
- 0.5%
Head Lice
< 6 years
- Safety & efficacy not established
> 6 years
- Hair: Apply to dry hair, leave in 8-12 hours
- May repeat if lice are present after 7-9 days
Adverse Effects
Frequency Not Defined
Stinging sensation
Contact hypersensitivity reaction
Chemical burns, including second-degree burns
Skin and scalp irritation
Conjunctivitis, accidental contact with eyes (mild)
Warnings
Contraindications
Hypersensitivity, neonates (<28 days) and infants
Cautions
Lotion is flammable; the lotion and wet hair should not be exposed to open flames or electric heat sources, including hair dryers and electric curlers; do not smoke while applying lotion or while hair is wet; allow hair to dry naturally and to remain uncovered after application
Only used on children under the direct supervision of an adult
If lotion comes into contact with eyes, flush immediately with water; consult a physician if eye irritation persists
If skin irritation occurs, discontinue use of product until irritation clears; reapply lotion, and if irritation reoccurs, consult a physician
Chemical burns including second-degree burns and stinging sensations may occur with use
Keep out of reach of children; close eyes tightly during product application; if accidentally placed in the eye, flush immediately with water; use only on scalp hair
Pregnancy & Lactation
Pregnancy
There was no evidence of teratogenicity in studies in rats and rabbits at doses up to 900 mg/kg/day and 100 mg/kg/day malathion, respectively. A study in rats failed to show any gross fetal abnormalities attributable to feeding malathion up to 2,500 ppm (~ 200 mg/kg/day) in diet during a three-generation evaluation period; these doses were approximately 40 to 180 times higher than the dose anticipated in 60 kg adult (based on body surface area and assuming 100% bioavailability); because animal reproduction studies are not always predictive of human responses, this drug should be used (or handled) during pregnancy only if clearly needed
Lactation
Malathion in an acetone vehicle has been reported to be absorbed through human skin to the extent of 8% of the applied dose; however, percutaneous absorption from the formulation has not been studied, and it is not known whether malathion is excreted in human milk; because many drugs are excreted in human milk, caution should be exercised when therapy is administered to (or handled by) a nursing mother
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Inhibits cholinesterase
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| Ovide topical - | 0.5 % lotion |  | |
| malathion topical - | 0.5 % lotion |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
malathion topical
MALATHION - TOPICAL
(mal-uh-THIGH-on)
COMMON BRAND NAME(S): Ovide
USES: This medication is used to treat head lice, tiny insects that infest and irritate your scalp. Malathion belongs to a class of drugs known as organophosphates. It works by paralyzing and killing lice and their eggs (nits).This drug is not recommended for use in newborns or infants younger than 1 year.
HOW TO USE: Learn all preparation and usage instructions in the product package. If you have any questions, ask your doctor or pharmacist.This medication is for use on hair and scalp only. Do not swallow. Be careful to avoid getting malathion in your nose, ears, mouth, vagina, or eyes. Protect eyes during application by keeping them tightly closed and covered with a cloth or towel. If the medication accidentally comes in contact with your eyes, flush them with water to reduce irritation. If irritation continues or you experience vision changes, talk to your doctor.Apply this medication onto dry hair and scalp. Use enough medication to make the hair and scalp wet, especially the back of the head and neck. Allow the hair to air-dry, uncovered. Wash hands after applying this medication. Leave malathion on the hair and scalp for 8-12 hours. Then shampoo and rinse well, especially the back of the head and neck.Run a fine-toothed comb (nit comb) through your wet hair to remove the dead lice and lice eggs. The infected person should be checked by another person for lice and nits. Please see the instructions in the product package for more details about nit removal. Consult your doctor if lice are still present after 7-9 days. Repeat treatment with this or other medication may be necessary.This medication may cause a slight stinging feeling on the scalp. This is normal. However, if skin irritation occurs, wash the scalp and hair right away, allow the irritation to clear, and try using the medication again. If the irritation returns, consult your doctor.This medication contains an ingredient that could easily catch fire (flammable). Avoid smoking, being around open flames (such as fireplaces, stoves, campfires), or electric heat sources such as heaters, hair dryers, and curlers/hair irons while using malathion.
SIDE EFFECTS: Burning, stinging, dry hair, or a temporary increase in dandruff may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using malathion, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, skin infections, skin or scalp problems (such as psoriasis, eczema), open sores/wounds on the scalp (such as minor cuts, scrapes).Constant or forceful scratching of the scalp may lead to a bacterial skin infection. Tell your doctor right away if you develop worsening redness or pus.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. If you are pregnant and applying this medication on another person, handle it with care.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: breathing problems, muscle weakness/paralysis, shaking, increased sweating/saliva/tears, increased urine, nausea, vomiting, diarrhea, anxiety, headache, confusion, dizziness, drowsiness, slow or fast heartbeat.
NOTES: Do not share this medication unless directed to do so by your doctor.One application is usually all that is needed. To avoid giving lice to another person or getting them again, all headwear, scarves, coats, and bed linens should be machine-washed with hot water and dried in a dryer (at high setting) for at least 20 minutes, dry cleaned, sealed in a plastic bag for 2 weeks, or sprayed with a disinfectant that kills lice. Brushes and combs should be soaked in hot water (hotter than 130 degrees F/54 degrees C) for 10 minutes, soaked in alcohol for 1 hour, or thrown away. Furniture and floors should be thoroughly vacuumed.People who are in close contact with the infected person, such as members of the same household, should also be checked for lice and nits. Treatment may be considered to prevent infestation even if live lice are not found on them.
MISSED DOSE: Not applicable.
STORAGE: Store at room temperature away from open flame. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised May 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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