oxiconazole (Rx)

Brand and Other Names:Oxistat
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream/lotion

  • 1%

Fungal Infections

Apply qDay-BID to affected & surrounding area

Tinea pedis: x4 weeks

Tinea cruris & corporis: x2 weeks

Dosage Forms & Strengths

cream/lotion

  • 1%

Fungal Infections

Apply qDay-BID to affected & surrounding area

These infections rarely occur in <12 years old

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Interactions

Interaction Checker

and oxiconazole

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

              Serious - Use Alternative (0)

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                  Minor (0)

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                    Adverse Effects

                    1-10%

                    Pruritus (1-2%)

                    Burning (1-2%)

                    <1%

                    Irritation

                    Stinging

                    Erythema

                    Rash

                    Folliculitis

                    Papules

                    Nodules

                    Maceration

                    Fissuring

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                    Warnings

                    Contraindications

                    Hypersensitivity

                    Not for ophthalmic or intravaginal use

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                    Pregnancy & Lactation

                    Pregnancy Category: B

                    Lactation: distributed into milk; use with caution in nursing women

                    Pregnancy Categories

                    A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                    B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                    C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                    D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                    X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                    NA: Information not available.

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                    Pharmacology

                    Absorption: minimal

                    Excretion: urine (0.3%) within 5 days

                    Enzymes inhibited: hepatic CYP3A4

                    Mechanism of Action

                    Fungistatic in action but may be fungicidal in high concentrations or against very susceptible organisms

                    Presumably exerts its antifungal activity by altering cellular membranes, resulting in increased membrane permeability, secondary metabolic effects, and growth inhibition

                    Appears that the antifungal activity of the drug results from interference with ergosterol synthesis, probably via inhibition of C-14 methylation of sterol intermediates (e.g., lanosterol)

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                    Images

                    BRAND FORM. UNIT PRICE PILL IMAGE
                    Oxistat topical
                    -
                    1 % cream
                    Oxistat topical
                    -
                    1 % cream
                    Oxistat topical
                    -
                    1 % cream
                    Oxistat topical
                    -
                    1 % lotion
                    Oxistat topical
                    -
                    1 % lotion
                    oxiconazole topical
                    -
                    1 % cream
                    oxiconazole topical
                    -
                    1 % cream
                    oxiconazole topical
                    -
                    1 % cream
                    oxiconazole topical
                    -
                    1 % cream
                    oxiconazole topical
                    -
                    1 % cream
                    oxiconazole topical
                    -
                    1 % cream

                    Copyright © 2010 First DataBank, Inc.

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                    Patient Handout

                    Patient Education
                    oxiconazole topical

                    OXICONAZOLE NITRATE - TOPICAL

                    (ox-ee-CON-uh-zole NYE-trate)

                    COMMON BRAND NAME(S): Oxistat

                    USES: Oxiconazole is used to treat skin infections such as athlete's foot, jock itch and ringworm. This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. Oxiconazole is an azole antifungal that works by preventing the growth of fungus.

                    HOW TO USE: Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply this medication to the affected skin, usually once or twice a day or as directed by your doctor. Dosage and length of treatment depends on the type of infection being treated. Do not apply this more often than prescribed. Your condition will not clear faster, but side effects may be increased.Apply enough cream or lotion to cover the affected area and some of the surrounding skin. If using the lotion, shake the bottle well just before applying. Use cotton balls or a soft cloth to apply the lotion. After applying this medication, wash your hands. Do not wrap, cover or bandage the area unless directed to do so by your doctor.Do not apply this medication in the eyes, nose, mouth, or vagina.Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day.Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after starting oxiconazole. Stopping the medication too early may allow the fungus to continue to grow, which may result in a relapse of the infection.Inform your doctor if your condition persists after 2-4 weeks of treatment or worsens at any time.

                    SIDE EFFECTS: Burning, stinging, swelling, irritation, redness, pimple-like bumps, tenderness, or flaking of the treated skin may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if any of these unlikely but serious side effects occur: blistering, oozing, open sores.A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                    PRECAUTIONS: Before using oxiconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals such as clotrimazole, ketoconazole, or miconazole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Consult your doctor before breast-feeding.

                    DRUG INTERACTIONS: Your healthcare professionals (such as your doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use.Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

                    OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

                    NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.When treating pityriasis, this medication may not cause an immediate return to normal skin color. It may take several months after treatment is completed for your natural skin color to return.

                    MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

                    STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from heat and light. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                    Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

                    IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                    Formulary

                    FormularyPatient Discounts

                    Adding plans allows you to compare formulary status to other drugs in the same class.

                    To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

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                    The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                    Tier Description
                    1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                    2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                    3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                    4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                    5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                    6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                    NC NOT COVERED – Drugs that are not covered by the plan.
                    Code Definition
                    PA Prior Authorization
                    Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                    QL Quantity Limits
                    Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                    ST Step Therapy
                    Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                    OR Other Restrictions
                    Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                    Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.