oxiconazole (Rx)

Brand and Other Names:Oxistat

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

cream/lotion

  • 1%

Fungal Infections

Apply qDay-BID to affected & surrounding area

Tinea pedis: x4 weeks

Tinea cruris & corporis: x2 weeks

Dosage Forms & Strengths

cream/lotion

  • 1%

Fungal Infections

Apply qDay-BID to affected & surrounding area

These infections rarely occur in <12 years old

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Interactions

Interaction Checker

and oxiconazole

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

              Serious - Use Alternative (0)

                Monitor Closely (0)

                  Minor (1)

                  • levoketoconazole

                    oxiconazole will increase the level or effect of levoketoconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown.

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                  Adverse Effects

                  1-10%

                  Pruritus (1-2%)

                  Burning (1-2%)

                  <1%

                  Irritation

                  Stinging

                  Erythema

                  Rash

                  Folliculitis

                  Papules

                  Nodules

                  Maceration

                  Fissuring

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                  Warnings

                  Contraindications

                  Hypersensitivity

                  Not for ophthalmic or intravaginal use

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                  Pregnancy & Lactation

                  Pregnancy Category: B

                  Lactation: distributed into milk; use with caution in nursing women

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Absorption: minimal

                  Excretion: urine (0.3%) within 5 days

                  Enzymes inhibited: hepatic CYP3A4

                  Mechanism of Action

                  Fungistatic in action but may be fungicidal in high concentrations or against very susceptible organisms

                  Presumably exerts its antifungal activity by altering cellular membranes, resulting in increased membrane permeability, secondary metabolic effects, and growth inhibition

                  Appears that the antifungal activity of the drug results from interference with ergosterol synthesis, probably via inhibition of C-14 methylation of sterol intermediates (e.g., lanosterol)

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                  Images

                  BRAND FORM. UNIT PRICE PILL IMAGE
                  Oxistat topical
                  -
                  1 % lotion
                  Oxistat topical
                  -
                  1 % lotion
                  Oxistat topical
                  -
                  1 % cream
                  Oxistat topical
                  -
                  1 % cream
                  Oxistat topical
                  -
                  1 % cream
                  Oxistat topical
                  -
                  1 % lotion
                  Oxistat topical
                  -
                  1 % lotion
                  oxiconazole topical
                  -
                  1 % cream
                  oxiconazole topical
                  -
                  1 % cream
                  oxiconazole topical
                  -
                  1 % cream
                  oxiconazole topical
                  -
                  1 % cream
                  oxiconazole topical
                  -
                  1 % cream
                  oxiconazole topical
                  -
                  1 % cream

                  Copyright © 2010 First DataBank, Inc.

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                  Patient Handout

                  Patient Education
                  oxiconazole topical

                  OXICONAZOLE NITRATE - TOPICAL

                  (ox-ee-CON-uh-zole NYE-trate)

                  COMMON BRAND NAME(S): Oxistat

                  USES: Oxiconazole is used to treat skin infections such as athlete's foot, jock itch and ringworm. This medication is also used to treat a skin condition known as pityriasis (tinea versicolor), a fungal infection that causes a lightening or darkening of the skin of the neck, chest, arms, or legs. Oxiconazole is an azole antifungal that works by preventing the growth of fungus.

                  HOW TO USE: Use this medication on the skin only. Clean and thoroughly dry the area to be treated. Apply this medication to the affected skin, usually once or twice a day or as directed by your doctor. Dosage and length of treatment depends on the type of infection being treated. Do not apply this more often than prescribed. Your condition will not clear faster, but side effects may be increased.Apply enough cream or lotion to cover the affected area and some of the surrounding skin. If using the lotion, shake the bottle well just before applying. Use cotton balls or a soft cloth to apply the lotion. After applying this medication, wash your hands. Do not wrap, cover or bandage the area unless directed to do so by your doctor.Do not apply this medication in the eyes, nose, mouth, or vagina.Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day.Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after starting oxiconazole. Stopping the medication too early may allow the fungus to continue to grow, which may result in a relapse of the infection.Tell your doctor if your condition lasts after 2-4 weeks of treatment or gets worse at any time.

                  SIDE EFFECTS: Burning, stinging, swelling, irritation, redness, pimple-like bumps, tenderness, or flaking of the treated skin may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: blistering, oozing, open sores.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                  PRECAUTIONS: Before using oxiconazole, tell your doctor or pharmacist if you are allergic to it; or to other azole antifungals such as clotrimazole, ketoconazole, or miconazole; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Consult your doctor before breast-feeding.

                  DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

                  OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

                  NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.When treating pityriasis, this medication may not cause an immediate return to normal skin color. It may take several months after treatment is completed for your natural skin color to return.

                  MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

                  STORAGE: Store at room temperature. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

                  Information last revised November 2022. Copyright(c) 2023 First Databank, Inc.

                  IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                  Formulary

                  FormularyPatient Discounts

                  Adding plans allows you to compare formulary status to other drugs in the same class.

                  To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

                  Adding plans allows you to:

                  • View the formulary and any restrictions for each plan.
                  • Manage and view all your plans together – even plans in different states.
                  • Compare formulary status to other drugs in the same class.
                  • Access your plan list on any device – mobile or desktop.

                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.