ozanimod (Pending FDA Approval)

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Dosing & Uses

AdultPediatric

Multiple Sclerosis

Pending FDA approval for relapsing forms of multiple sclerosis ( MS )

Safety and efficacy not established

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Interactions

Interaction Checker

and ozanimod

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Headache

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            Warnings

            Contraindications

            Hypersensitivity

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            Pregnancy & Lactation

            Pregnancy

            Data are not available

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Oral, sphingosine 1-phosphate (S1P) receptor modulator

            Binds with high affinity selectively to S1P subtypes 1 (S1P1) and 5 (S1P5); blocks lymphocyte egress from lymph nodes, reducing the number of lymphocytes in peripheral blood

            Mechanism by which siponimod exerts therapeutic effects in MS is unknown, but may involve reduction of lymphocyte migration into the central nervous system

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            Administration

            Oral Administration

            For oral administration

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            Images

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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.