Dosing & Uses
Dosage Forms & Strengths
gel
- 0.1%
AIDS-Related Kaposi's Sarcoma
Initially apply q12hr to lesions; may increase to q6-8hr depending on individual lesion tolerance; frequency may be reduced if toxicity occurs
T-Cell Lymphomas (Off-label)
Apply q12 hr to cutaneous lesions
Safety & efficacy not established
Adverse Effects
>10%
Rash (25-77%)
Pruritus (8-11%)
Paresthesia (3-22%)
Pain (<34%)
Pruritus (11%)
1-10%
Exfoliative dermatitis (3-9%)
Edema (3-8%)
Skin disorders (8%)
Paresthesia (3%)
Warnings
Contraindications
Hypersensitivity to retinoids
Concomitant systemic anti-Kaposi's sarcoma treatment
Pregnancy
Cautions
Minimize treated area exposure to sun or other sources of UV
Not for concurrent use with DEET products
Use precautions for handling and disoposal
Safety not established in children or the elderly
Handle with caution and dispose appropriately
Pregnancy & Lactation
Pregnancy Category: D
Lactation: excretion in milk unknown/not recommended
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Binds to retinoid receptors, which in turn promotes cellular differentiation and inhibits growth of Kaposi's sarcoma
Pharmacokinetics
Onset: 2-14 wk
Absorption: Negligible
Metabolism: In vitro data unlikely relevant since little absorption
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Formulary
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