Dosing & Uses
Dosage Forms & Strengths
oral liquid: Schedule II
- 118mL/bottle
- Each mL contains 10 mg of anhydrous morphine
Diarrhea
Indicated to treat diarrhea
6 mg (0.6 mL) PO q6hr; not to exceed 6 mL/day
Chronic Diarrhea (Orphan)
Orphan designation for treatment of chronic diarrhea in short bowel syndrome patients with an inadequate response to antidiarrheal treatment
Orphan sponsor
- Marathon Pharmaceuticals, LLC; Nine Parkway Blvd North; Deerfield, IL 60015
Safety and efficacy not established
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (1)
- alvimopan
alvimopan, opium tincture. receptor binding competition. Contraindicated. Contraindicated in opioid tolerant patients (ie, those who have taken therapeutic doses of opioids for >7 consecutive days immediately prior to taking alvimopan). Patients recently exposed to opioids are expected to be more sensitive to the effects of alvimopan and therefore may experience abdominal pain, nausea and vomiting, and diarrhea.
Serious - Use Alternative (27)
- buprenorphine
buprenorphine, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.
- buprenorphine buccal
buprenorphine buccal, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.
- butorphanol
butorphanol, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.
- calcium/magnesium/potassium/sodium oxybates
opium tincture, calcium/magnesium/potassium/sodium oxybates. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- cimetidine
cimetidine increases effects of opium tincture by decreasing metabolism. Avoid or Use Alternate Drug.
- clonidine
clonidine, opium tincture. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration enhances CNS depressant effects.
- desvenlafaxine
desvenlafaxine and opium tincture both increase serotonin levels. Avoid or Use Alternate Drug. May cause serotonin syndrome
- eluxadoline
opium tincture, eluxadoline. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid coadministration with other drugs that cause constipation. Increases risk for constipation related serious adverse reactions. .
- fentanyl
fentanyl, opium tincture. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
- fentanyl intranasal
fentanyl intranasal, opium tincture. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
- fentanyl transdermal
fentanyl transdermal, opium tincture. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
- fentanyl transmucosal
fentanyl transmucosal, opium tincture. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.
- isocarboxazid
isocarboxazid increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.
- linezolid
linezolid increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.
- metoclopramide intranasal
opium tincture, metoclopramide intranasal. Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.
- nalbuphine
nalbuphine, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.
- olopatadine intranasal
opium tincture and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- pentazocine
pentazocine, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx.
- phenelzine
phenelzine increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.
- procarbazine
procarbazine increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. MAOIs may potentiate CNS depression and hypotension. Do not use within 14 days of MAOI use. .
- ropeginterferon alfa 2b
ropeginterferon alfa 2b and opium tincture both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.
- selegiline
selegiline increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death.
- selegiline transdermal
selegiline transdermal increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death.
- sodium oxybate
opium tincture, sodium oxybate. Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.
- tramadol
tramadol, opium tincture. Other (see comment). Avoid or Use Alternate Drug. Comment: Tramadol may reinitiate opiate dependence in pts. previously addicted to other opiates; it may also provoke withdrawal Sx. in pts. who are currently opiate dependent.
- tranylcypromine
tranylcypromine increases toxicity of opium tincture by unknown mechanism. Avoid or Use Alternate Drug. Risk of hypotension, hyperpyrexia, somnolence, or death; separate by 14 d.
- venlafaxine
venlafaxine and opium tincture both increase serotonin levels. Avoid or Use Alternate Drug. May cause serotonin syndrome
Monitor Closely (200)
- acrivastine
acrivastine and opium tincture both increase sedation. Use Caution/Monitor.
- albuterol
opium tincture increases and albuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- alfentanil
alfentanil and opium tincture both increase sedation. Use Caution/Monitor.
- alprazolam
alprazolam and opium tincture both increase sedation. Use Caution/Monitor.
- amisulpride
amisulpride and opium tincture both increase sedation. Use Caution/Monitor.
- amitriptyline
opium tincture and amitriptyline both increase sedation. Use Caution/Monitor.
- amobarbital
amobarbital and opium tincture both increase sedation. Use Caution/Monitor.
- amoxapine
opium tincture and amoxapine both increase sedation. Use Caution/Monitor.
- apomorphine
opium tincture and apomorphine both increase sedation. Use Caution/Monitor.
- arformoterol
opium tincture increases and arformoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- aripiprazole
opium tincture and aripiprazole both increase sedation. Use Caution/Monitor.
- armodafinil
opium tincture increases and armodafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- asenapine
asenapine and opium tincture both increase sedation. Use Caution/Monitor.
- asenapine transdermal
asenapine transdermal and opium tincture both increase sedation. Use Caution/Monitor.
- avapritinib
avapritinib and opium tincture both increase sedation. Use Caution/Monitor.
- azelastine
azelastine and opium tincture both increase sedation. Use Caution/Monitor.
- baclofen
baclofen and opium tincture both increase sedation. Use Caution/Monitor.
- belladonna and opium
belladonna and opium and opium tincture both increase sedation. Use Caution/Monitor.
- benperidol
opium tincture and benperidol both increase sedation. Use Caution/Monitor.
- benzhydrocodone/acetaminophen
benzhydrocodone/acetaminophen and opium tincture both increase sedation. Use Caution/Monitor.
- benzphetamine
opium tincture increases and benzphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- brexanolone
brexanolone, opium tincture. Either increases toxicity of the other by sedation. Use Caution/Monitor.
- brexpiprazole
brexpiprazole and opium tincture both increase sedation. Use Caution/Monitor.
- brimonidine
brimonidine and opium tincture both increase sedation. Use Caution/Monitor.
- brivaracetam
brivaracetam and opium tincture both increase sedation. Use Caution/Monitor.
- brompheniramine
brompheniramine and opium tincture both increase sedation. Use Caution/Monitor.
- buprenorphine
buprenorphine and opium tincture both increase sedation. Use Caution/Monitor.
- buprenorphine buccal
buprenorphine buccal and opium tincture both increase sedation. Use Caution/Monitor.
- buprenorphine subdermal implant
buprenorphine subdermal implant and opium tincture both increase sedation. Use Caution/Monitor.
- buprenorphine transdermal
buprenorphine transdermal and opium tincture both increase sedation. Use Caution/Monitor.
- buprenorphine, long-acting injection
buprenorphine, long-acting injection and opium tincture both increase sedation. Use Caution/Monitor.
- butabarbital
butabarbital and opium tincture both increase sedation. Use Caution/Monitor.
- butalbital
butalbital and opium tincture both increase sedation. Use Caution/Monitor.
- butorphanol
butorphanol and opium tincture both increase sedation. Use Caution/Monitor.
- caffeine
opium tincture increases and caffeine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- carbinoxamine
carbinoxamine and opium tincture both increase sedation. Use Caution/Monitor.
- carisoprodol
carisoprodol and opium tincture both increase sedation. Use Caution/Monitor.
- cenobamate
cenobamate, opium tincture. Either increases effects of the other by sedation. Use Caution/Monitor.
- chloral hydrate
chloral hydrate and opium tincture both increase sedation. Use Caution/Monitor.
- chlordiazepoxide
chlordiazepoxide and opium tincture both increase sedation. Use Caution/Monitor.
- chlorpheniramine
chlorpheniramine and opium tincture both increase sedation. Use Caution/Monitor.
- chlorpromazine
opium tincture and chlorpromazine both increase sedation. Use Caution/Monitor.
- chlorzoxazone
chlorzoxazone and opium tincture both increase sedation. Use Caution/Monitor.
- cinnarizine
cinnarizine and opium tincture both increase sedation. Use Caution/Monitor.
- clemastine
clemastine and opium tincture both increase sedation. Use Caution/Monitor.
- clomipramine
opium tincture and clomipramine both increase sedation. Use Caution/Monitor.
- clonazepam
clonazepam and opium tincture both increase sedation. Use Caution/Monitor.
- clorazepate
clorazepate and opium tincture both increase sedation. Use Caution/Monitor.
- clozapine
opium tincture and clozapine both increase sedation. Use Caution/Monitor.
- codeine
codeine and opium tincture both increase sedation. Use Caution/Monitor.
- cyclizine
cyclizine and opium tincture both increase sedation. Use Caution/Monitor.
- cyclobenzaprine
cyclobenzaprine and opium tincture both increase sedation. Use Caution/Monitor.
- cyproheptadine
cyproheptadine and opium tincture both increase sedation. Use Caution/Monitor.
- dantrolene
dantrolene and opium tincture both increase sedation. Use Caution/Monitor.
- daridorexant
opium tincture and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.
- desflurane
desflurane and opium tincture both increase sedation. Use Caution/Monitor. Opioids may decrease MAC requirements, less inhalation anesthetic may be required.
- desipramine
opium tincture and desipramine both increase sedation. Use Caution/Monitor.
- dexchlorpheniramine
dexchlorpheniramine and opium tincture both increase sedation. Use Caution/Monitor.
- dexfenfluramine
opium tincture increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dexmedetomidine
dexmedetomidine and opium tincture both increase sedation. Use Caution/Monitor.
- dexmethylphenidate
opium tincture increases and dexmethylphenidate decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextroamphetamine
opium tincture increases and dextroamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dextromoramide
dextromoramide and opium tincture both increase sedation. Use Caution/Monitor.
- diamorphine
diamorphine and opium tincture both increase sedation. Use Caution/Monitor.
- diazepam
diazepam and opium tincture both increase sedation. Use Caution/Monitor.
- diethylpropion
opium tincture increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- difelikefalin
difelikefalin and opium tincture both increase sedation. Use Caution/Monitor.
- difenoxin hcl
difenoxin hcl and opium tincture both increase sedation. Use Caution/Monitor.
- dimenhydrinate
dimenhydrinate and opium tincture both increase sedation. Use Caution/Monitor.
- diphenhydramine
diphenhydramine and opium tincture both increase sedation. Use Caution/Monitor.
- diphenoxylate hcl
diphenoxylate hcl and opium tincture both increase sedation. Use Caution/Monitor.
- dipipanone
dipipanone and opium tincture both increase sedation. Use Caution/Monitor.
- dobutamine
opium tincture increases and dobutamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopamine
opium tincture increases and dopamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dopexamine
opium tincture increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- dosulepin
opium tincture and dosulepin both increase sedation. Use Caution/Monitor.
- doxepin
opium tincture and doxepin both increase sedation. Use Caution/Monitor.
- doxylamine
doxylamine and opium tincture both increase sedation. Use Caution/Monitor.
- droperidol
opium tincture and droperidol both increase sedation. Use Caution/Monitor.
- eltrombopag
eltrombopag increases levels of opium tincture by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.
- ephedrine
opium tincture increases and ephedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine
opium tincture increases and epinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- epinephrine racemic
opium tincture increases and epinephrine racemic decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- estazolam
estazolam and opium tincture both increase sedation. Use Caution/Monitor.
- ethanol
opium tincture and ethanol both increase sedation. Use Caution/Monitor.
- etomidate
etomidate and opium tincture both increase sedation. Use Caution/Monitor.
- fenfluramine
opium tincture increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- fentanyl
fentanyl and opium tincture both increase sedation. Use Caution/Monitor.
- fentanyl intranasal
fentanyl intranasal and opium tincture both increase sedation. Use Caution/Monitor.
- fentanyl iontophoretic transdermal system
fentanyl iontophoretic transdermal system and opium tincture both increase sedation. Use Caution/Monitor.
- fentanyl transdermal
fentanyl transdermal and opium tincture both increase sedation. Use Caution/Monitor.
- fluphenazine
opium tincture and fluphenazine both increase sedation. Use Caution/Monitor.
- flurazepam
flurazepam and opium tincture both increase sedation. Use Caution/Monitor.
- formoterol
opium tincture increases and formoterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ganaxolone
opium tincture and ganaxolone both increase sedation. Use Caution/Monitor.
- haloperidol
opium tincture and haloperidol both increase sedation. Use Caution/Monitor.
- hydromorphone
hydromorphone and opium tincture both increase sedation. Use Caution/Monitor.
- hydroxyzine
hydroxyzine and opium tincture both increase sedation. Use Caution/Monitor.
- iloperidone
opium tincture and iloperidone both increase sedation. Use Caution/Monitor.
- imipramine
opium tincture and imipramine both increase sedation. Use Caution/Monitor.
- isocarboxazid
opium tincture, isocarboxazid. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.
- isoproterenol
opium tincture increases and isoproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ketamine
ketamine and opium tincture both increase sedation. Use Caution/Monitor.
- ketotifen, ophthalmic
opium tincture and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.
- lasmiditan
lasmiditan, opium tincture. Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.
- lemborexant
lemborexant, opium tincture. Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.
- levalbuterol
opium tincture increases and levalbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- levorphanol
levorphanol and opium tincture both increase sedation. Use Caution/Monitor.
- linezolid
opium tincture, linezolid. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.
- lisdexamfetamine
opium tincture increases and lisdexamfetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- lofepramine
opium tincture and lofepramine both increase sedation. Use Caution/Monitor.
- lofexidine
opium tincture and lofexidine both increase sedation. Use Caution/Monitor.
- loprazolam
loprazolam and opium tincture both increase sedation. Use Caution/Monitor.
- lorazepam
lorazepam and opium tincture both increase sedation. Use Caution/Monitor.
- lormetazepam
lormetazepam and opium tincture both increase sedation. Use Caution/Monitor.
- loxapine
opium tincture and loxapine both increase sedation. Use Caution/Monitor.
- loxapine inhaled
opium tincture and loxapine inhaled both increase sedation. Use Caution/Monitor.
- lurasidone
lurasidone, opium tincture. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Potential for increased CNS depressant effects when used concurrently; monitor for increased adverse effects and toxicity.
- maprotiline
opium tincture and maprotiline both increase sedation. Use Caution/Monitor.
- marijuana
opium tincture and marijuana both increase sedation. Use Caution/Monitor.
- melatonin
opium tincture and melatonin both increase sedation. Use Caution/Monitor.
- meperidine
meperidine and opium tincture both increase sedation. Use Caution/Monitor.
- meprobamate
opium tincture and meprobamate both increase sedation. Use Caution/Monitor.
- metaproterenol
opium tincture increases and metaproterenol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- metaxalone
metaxalone and opium tincture both increase sedation. Use Caution/Monitor.
- methadone
methadone and opium tincture both increase sedation. Use Caution/Monitor.
- methamphetamine
opium tincture increases and methamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- methocarbamol
methocarbamol and opium tincture both increase sedation. Use Caution/Monitor.
- methylenedioxymethamphetamine
opium tincture increases and methylenedioxymethamphetamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- midazolam
midazolam and opium tincture both increase sedation. Use Caution/Monitor.
- midazolam intranasal
midazolam intranasal, opium tincture. Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.
- midodrine
opium tincture increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- mirtazapine
opium tincture and mirtazapine both increase sedation. Use Caution/Monitor.
- modafinil
opium tincture increases and modafinil decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- morphine
morphine and opium tincture both increase sedation. Use Caution/Monitor.
- motherwort
opium tincture and motherwort both increase sedation. Use Caution/Monitor.
- moxonidine
opium tincture and moxonidine both increase sedation. Use Caution/Monitor.
- nabilone
opium tincture and nabilone both increase sedation. Use Caution/Monitor.
- nalbuphine
nalbuphine and opium tincture both increase sedation. Use Caution/Monitor.
- norepinephrine
opium tincture increases and norepinephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- nortriptyline
opium tincture and nortriptyline both increase sedation. Use Caution/Monitor.
- olanzapine
opium tincture and olanzapine both increase sedation. Use Caution/Monitor.
- orphenadrine
orphenadrine and opium tincture both increase sedation. Use Caution/Monitor.
- oxazepam
oxazepam and opium tincture both increase sedation. Use Caution/Monitor.
- oxycodone
opium tincture and oxycodone both increase sedation. Use Caution/Monitor.
- oxymorphone
opium tincture and oxymorphone both increase sedation. Use Caution/Monitor.
- paliperidone
opium tincture and paliperidone both increase sedation. Use Caution/Monitor.
- papaveretum
opium tincture and papaveretum both increase sedation. Use Caution/Monitor.
- papaverine
opium tincture and papaverine both increase sedation. Use Caution/Monitor.
- pegvisomant
opium tincture decreases effects of pegvisomant by unknown mechanism. Use Caution/Monitor.
- pentazocine
opium tincture and pentazocine both increase sedation. Use Caution/Monitor.
- pentobarbital
pentobarbital and opium tincture both increase sedation. Use Caution/Monitor.
- perphenazine
opium tincture and perphenazine both increase sedation. Use Caution/Monitor.
- phendimetrazine
opium tincture increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenelzine
opium tincture, phenelzine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.
- phenobarbital
phenobarbital and opium tincture both increase sedation. Use Caution/Monitor.
- phentermine
opium tincture increases and phentermine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine
opium tincture increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- phenylephrine PO
opium tincture increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
- pholcodine
opium tincture and pholcodine both increase sedation. Use Caution/Monitor.
- pimozide
opium tincture and pimozide both increase sedation. Use Caution/Monitor.
- pirbuterol
opium tincture increases and pirbuterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- primidone
primidone and opium tincture both increase sedation. Use Caution/Monitor.
- prochlorperazine
opium tincture and prochlorperazine both increase sedation. Use Caution/Monitor.
- promethazine
promethazine and opium tincture both increase sedation. Use Caution/Monitor.
- propofol
propofol and opium tincture both increase sedation. Use Caution/Monitor.
- propylhexedrine
opium tincture increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- protriptyline
opium tincture and protriptyline both increase sedation. Use Caution/Monitor.
- quazepam
quazepam and opium tincture both increase sedation. Use Caution/Monitor.
- quetiapine
opium tincture and quetiapine both increase sedation. Use Caution/Monitor.
- ramelteon
opium tincture and ramelteon both increase sedation. Use Caution/Monitor.
- rasagiline
rasagiline increases toxicity of opium tincture by unknown mechanism. Use Caution/Monitor. Risk of hypotension, hyperpyrexia, somnolence, or death.
- risperidone
opium tincture and risperidone both increase sedation. Use Caution/Monitor.
- salmeterol
opium tincture increases and salmeterol decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- scullcap
opium tincture and scullcap both increase sedation. Use Caution/Monitor.
- secobarbital
secobarbital and opium tincture both increase sedation. Use Caution/Monitor.
- selegiline transdermal
opium tincture, selegiline transdermal. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.
- sevoflurane
sevoflurane and opium tincture both increase sedation. Use Caution/Monitor.
- shepherd's purse
opium tincture and shepherd's purse both increase sedation. Use Caution/Monitor.
- stiripentol
stiripentol, opium tincture. Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.
- sufentanil
opium tincture and sufentanil both increase sedation. Use Caution/Monitor.
- tapentadol
opium tincture and tapentadol both increase sedation. Use Caution/Monitor.
- temazepam
temazepam and opium tincture both increase sedation. Use Caution/Monitor.
- terbutaline
opium tincture increases and terbutaline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- thioridazine
opium tincture and thioridazine both increase sedation. Use Caution/Monitor.
- thiothixene
opium tincture and thiothixene both increase sedation. Use Caution/Monitor.
- topiramate
opium tincture and topiramate both increase sedation. Modify Therapy/Monitor Closely.
- tramadol
opium tincture and tramadol both increase sedation. Use Caution/Monitor.
- tranylcypromine
opium tincture, tranylcypromine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of serotonin syndrome.
- trazodone
opium tincture and trazodone both increase sedation. Use Caution/Monitor.
- triazolam
triazolam and opium tincture both increase sedation. Use Caution/Monitor.
- triclofos
triclofos and opium tincture both increase sedation. Use Caution/Monitor.
- trifluoperazine
opium tincture and trifluoperazine both increase sedation. Use Caution/Monitor.
- trimipramine
opium tincture and trimipramine both increase sedation. Use Caution/Monitor.
- triprolidine
triprolidine and opium tincture both increase sedation. Use Caution/Monitor.
- xylometazoline
opium tincture increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- yohimbine
opium tincture increases and yohimbine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
- ziconotide
opium tincture and ziconotide both increase sedation. Use Caution/Monitor.
- ziprasidone
opium tincture and ziprasidone both increase sedation. Use Caution/Monitor.
- zotepine
opium tincture and zotepine both increase sedation. Use Caution/Monitor.
Minor (7)
- brimonidine
brimonidine increases effects of opium tincture by pharmacodynamic synergism. Minor/Significance Unknown. Increased CNS depression.
- dextroamphetamine
dextroamphetamine increases effects of opium tincture by unspecified interaction mechanism. Minor/Significance Unknown.
- eucalyptus
opium tincture and eucalyptus both increase sedation. Minor/Significance Unknown.
- lidocaine
lidocaine increases toxicity of opium tincture by pharmacodynamic synergism. Minor/Significance Unknown. Risk of increased CNS depression.
- rifampin
rifampin decreases levels of opium tincture by increasing metabolism. Minor/Significance Unknown.
- sage
opium tincture and sage both increase sedation. Minor/Significance Unknown.
- ziconotide
ziconotide, opium tincture. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Additive decreased GI motility. Additive analgesia. Ziconotide does NOT potentiate opioid induced respiratory depression.
Adverse Effects
Frequency Not Defined
Constipation
Nausea
Vomiting
Pruritus
Urticaria
Warnings
Contraindications
Hypersensitivity
Respiratory disease/depression, diarrhea due to poison (until toxic material eliminated from the GI tract), pseudomembranous colitis
Cautions
Use caution in the elderly, in debilitated individuals, and in patients with increased intracranial pressure, cerebral arteriosclerosis, hepatic cirrhosis or liver insufficiency, gastrointestinal hemorrhage, myxedema, emphysema, and bronchial asthma
Addiction can result from opium usage; opium preparations should be given in smallest effective dose and as infrequently as possible to minimize development of tolerance and physical dependence
Opium tincture contains 25 times more morphine than paregoric & should never be confused with the latter
When preparations containing opium administered in combination with other drugs, cautions applicable to each ingredient should be taken into account; reduced dosage is indicated in poor-risk patients, the very young or very old patient, and those who are receiving other central-nervous-system depressants
Caution in patients with acute adrenal insufficiency (eg, Addison's disease)
Caution in patients with biliary tract dysfunction
Caution in patients with GI hemorrhage
Pregnancy & Lactation
Pregnancy
Unknown whether drug may cause fetal harm when administered to pregnant females or can affect reproduction capacity
No animal studies conducted
Lactation
Exercise caution when administering to nursing females
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Opium, because of its morphine content, inhibits GI motility and propulsion, diminishes digestive secretion; increases GI muscle tone
Absorption
Well absorbed from the gastrointestinal tract
Metabolism
Extensively metabolized in liver, undergoes conjugation with glucuronic acid
Metabolites: Morphine-3-glucuronide, morphine-3-6-diglucuronide
Elimination
Excretion: Urine (~75% [unchanged])
Administration
Oral Administration
May take with or without food
Storage
Store 20-25ºC (68-77ºF)
Protect from light
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| opium tincture oral - | 10 mg/mL (morphine) liquid |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
opium tincture oral
OPIUM TINCTURE - ORAL
(OH-pee-um)
USES: This medication is used to treat diarrhea. It helps to decrease how often you have bowel movements. It works by slowing the movement of the intestines. Opium belongs to a class of drugs known as opioid pain relievers, but this medication acts mainly to slow the gut.
HOW TO USE: Take this medication by mouth as directed by your doctor, usually 4 times daily. It may be taken with food or meals if stomach upset occurs.Carefully measure each dose using the dropper provided. If your medication comes in an oral dosing syringe, use the syringe to measure the dose. Do not use a household spoon because you may not get the correct dose. Do not inject the medication. The dose may be mixed with a small amount of water just before taking.The dosage is based on your medical condition and response to treatment.If you suddenly stop using this medication, you may have withdrawal symptoms (such as sweating, nausea, vomiting, restlessness). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used opium for a long time or in high doses. Tell your doctor or pharmacist right away if you have withdrawal.Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Do not increase your dose, take it more often, or use it for a longer time than prescribed. Properly stop the medication when so directed.When used for a long time, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.Diarrhea can sometimes cause dehydration. It is important that you drink the proper amount of fluids and electrolytes to prevent this effect. Tell your doctor right away if you develop signs of dehydration (such as unusual decreased urination, unusual dry mouth/thirst, fast heartbeat, or dizziness/lightheadedness). You may also need to change to a bland diet during this time to reduce irritation to your stomach/intestines. Consult your doctor or pharmacist for more information.Tell your doctor if your condition lasts or gets worse after 2 to 3 days of treatment.
SIDE EFFECTS: Nausea, vomiting, lightheadedness, dizziness, drowsiness, or constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as agitation, confusion, hallucinations), severe stomach/abdominal pain, difficulty urinating.Get medical help right away if you have any very serious side effects, including: fainting, seizure, slow/shallow breathing, severe drowsiness/difficulty waking up.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before taking this medication, tell your doctor or pharmacist if you are allergic to it; or to other opioids (such as codeine, morphine); or to papaverine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (such as head injury, tumor, seizures), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD), kidney disease, liver disease, mental/mood disorders (such as confusion, depression), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus), difficulty urinating (such as due to enlarged prostate), disease of the pancreas (pancreatitis), gallbladder disease.This drug may make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).This product also contains alcohol. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid alcohol in your diet. Ask your doctor or pharmacist about using this product safely.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Children may be more sensitive to the side effects of this drug, especially slow/shallow breathing.Older adults may be more sensitive to side effects of this drug, especially slow/shallow breathing and drowsiness.Before using this medication, women of childbearing age should talk with their doctor(s) about the risks and benefits. Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It may slightly increase the risk of birth defects if used during the first two months of pregnancy. Also, using it for a long time or in high doses near the expected delivery date may harm the unborn baby. To lessen the risk, take the smallest effective dose for the shortest possible time. Tell the doctor right away if you notice any symptoms in your newborn baby such as slow/shallow breathing, irritability, crying that is unusual or doesn't stop, vomiting, or diarrhea.This drug passes into breast milk and may have undesirable effects on a nursing infant. Tell the doctor right away if your baby develops unusual sleepiness, difficulty feeding, or trouble breathing. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: certain pain medications (mixed opioid agonist/antagonists such as pentazocine, nalbuphine, butorphanol), naltrexone.The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Tell your doctor or pharmacist if you are taking other products such as other opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: slowed breathing, slow heartbeat, severe dizziness/drowsiness, fainting, muscle weakness.
NOTES: Do not share this medication with others. Sharing it is against the law.
MISSED DOSE: If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised October 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
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