Dosing & Uses
Dosage Forms & Strengths
ophthalmic solution
- 0.1% (Patanol [OTC])
- 0.2% (Pataday [OTC])
- 0.7% (Pazeo)
Allergic Conjunctivitis
Indicated for the treatment of ocular itching associated with allergic conjunctivitis
0.1% solution (Patanol): 1 gtt BID in affected eye(s) at an interval of 6-8 hr
0.2% solution (Pataday): 1 gtt in affected eye(s) qDay
0.7% solution (Pazeo): 1 gtt in affected eye(s) qDay
Dosage Forms & Strengths
ophthalmic solution
- 0.1% (Patanol [OTC])
- 0.2% (Pataday [OTC])
- 0.7% (Pazeo)
Allergic Conjunctivitis
Indicated for the treatment of ocular itching associated with allergic conjunctivitis
<2 years (Pataday, Pazeo) or <3 years (Patanol): Safety and efficacy not established
0.1% solution (Patanol): 1-2 gtt BID in affected eye(s) at an interval of 6-8 hr
0.2% solution (Pataday): 1 gtt in affected eye(s) qDay
0.7% solution (Pazeo): 1 gtt in affected eye(s) qDay
Adverse Effects
1-10%
Headache (7%)
Asthenia (<5%)
Blurred vision (<5%)
Burning or stinging (<5%)
Cold syndrome (<5%)
Dry eye (<5%)
Foreign body sensation (<5%)
Hyperemia (<5%)
Hypersensitivity (<5%)
Keratitis (<5%)
Lid edema (<5%)
Nausea (<5%)
Pharyngitis (<5%)
Pruritus (<5%)
Rhinitis (<5%)
Sinusitis (<5%)
Taste perversion (<5%)
Warnings
Contraindications
Pataday and Pazeo: None
Patanol: Known hypersensitivity
Cautions
Do not wear a contact lens if their eye is red
Benzalkonium chloride, a preservative in ophthalmic solution, may be absorbed by soft contact lenses
For external use only; do not use if solution changes color or becomes cloudy, patient is sensitive to any ingredient in the product, or to treat contact lens irritation
Use caution when using product; to avoid contamination, do not touch tip of container to any surface; remove contact lenses before use; wait at least 10 min before reinserting lenses after use
Discontinue use and see healthcare practitioner if eye pain, changes in vision, increased redness of the eye or itching worsens or lasts for more than 72 hours
Keep product out of reach of children; if swallowed, contact Poison Control Center right away
Pregnancy & Lactation
Pregnancy
There are no adequate and well-controlled studies in pregnant women
Animal studies
- Olopatadine was found not to be teratogenic in rats and rabbits
- Rats treated at 600 mg/kg/day, or 150,000 times the MROHD and rabbits treated at 400 mg/kg/day, or ~100,000 times the MROHD, during organogenesis showed a decrease in live fetuses
- In addition, rats treated with 600 mg/kg/day of olopatadine during organogenesis showed a decrease in fetal weight
- Further, rats treated with 600 mg/kg/day of olopatadine during late gestation through the lactation period showed a decrease in neonatal survival and body weight
Lactation
Olopatadine has been identified in the milk of nursing rats following oral administration
It is unknown whether topical ocular administration could result in sufficient systemic absorption to produce detectable quantities in the human breast milk
Exercise caution when using olopatadine hydrochloride is administered to a nursing mother
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Antihistamine (H1 antagonist); inhibits release of histamine from mast cells and histamine induced effects on conjunctival epithelial cells.
Pharmacokinetics
Absorption: Limited systemic
Half-Life: 3 hr
Protein binding: ~55%
Metabolites: N-desmethyl olopatadine; olopatadine N-oxide
Half-life: 3 hr
Excretion: Urine (60-70%); feces (17%)
Images
| BRAND | FORM. | UNIT PRICE | PILL IMAGE |
|---|---|---|---|
| olopatadine ophthalmic (eye) - | 0.2 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.1 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.1 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.1 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.2 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.1 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.2 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.2 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.1 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.2 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.1 % drops |  | |
| olopatadine ophthalmic (eye) - | 0.2 % drops |  | |
| Patanase nasal - | 0.6 % aerosol |  | |
| olopatadine nasal - | 0.6 % aerosol |  | |
| olopatadine nasal - | 0.6 % aerosol |  | |
| olopatadine nasal - | 0.6 % aerosol |  | |
| olopatadine nasal - | 0.6 % aerosol |  |
Copyright © 2010 First DataBank, Inc.
Patient Handout
olopatadine ophthalmic (eye)
OLOPATADINE - OPHTHALMIC
(oh-low-PAT-uh-deen)
COMMON BRAND NAME(S): Pataday, Patanol, Pazeo
USES: This medication is an antihistamine used to treat itching and redness in the eyes due to allergies.This medication is not recommended for the treatment of eye irritation due to wearing contact lenses.
HOW TO USE: If you are using the over-the-counter product to self-treat, read and follow all directions on the product package before using this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, use it as directed.Apply this medication in the affected eye(s) as directed by the product package or by your doctor, usually once or twice a day.To apply eye drops, wash hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.If you are wearing contact lenses, remove them before using eye drops. Wait at least 10 minutes before replacing your contact lenses. Tilt your head back, look upward, and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward, gently close your eyes, and place one finger at the corner of your eye (near the nose). Apply gentle pressure for 1 to 2 minutes before opening your eyes. This will prevent the medication from draining out. Try not to blink or rub your eye. If directed to use this medication in both eyes, repeat these steps for your other eye. Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (such as drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the drops to enter the eye.Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time(s) each day.If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.
SIDE EFFECTS: Headache, blurred vision, burning/stinging/redness/dryness of the eye, eyelid swelling, or a feeling as if something is in your eye may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
PRECAUTIONS: Before using olopatadine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history.After you apply this drug, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that requires clear vision until you can do it safely.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.
OVERDOSE: This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.
NOTES: Keep all regular medical and lab appointments.
MISSED DOSE: If you are using this product on a regular schedule and miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
STORAGE: Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Information last revised May 2023. Copyright(c) 2023 First Databank, Inc.
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.
Adding plans allows you to:
- View the formulary and any restrictions for each plan.
- Manage and view all your plans together – even plans in different states.
- Compare formulary status to other drugs in the same class.
- Access your plan list on any device – mobile or desktop.
