olopatadine intranasal (Rx)

Brand and Other Names:Patanase
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

nasal spray

  • 6% (665mcg/100 microliters spray)

Seasonal Allergic Rhinitis

2 sprays per nostril q12hr

Dosage Forms & Strengths

nasal spray

  • 6% (665mcg/100 microliters spray)

Seasonal Allergic Rhinitis

<6 years: Safety and efficacy not established

6-12 years: 1 spray per nostril q12hr

>12 years: 2 sprays per nostril q12hr

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Interactions

Interaction Checker

and olopatadine intranasal

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            >10%

            Bitter taste (12.8%; 1% pediatric)

            Respiratory epistaxis (3-25%)

            1-10%

            Headache (4.4%)

            Depression (2%)

            Fatigue (1%)

            Somnolence (1%)

            Weight gain (1%)

            Epistaxis (3.2%; 5.7% pediatric)

            Upper respiratory tract infection (2.6% pediatric)

            Pharyngolaryngeal pain (2.2%)

            Postnasal drip (1.5%)

            Cough (1.4%)

            Urinary tract infection (1.2%)

            Upper respiratory tract infection in children (3%)

            <1%

            CPK elevation

            Dry mouth

            Anosmia

            Hyposmia

            Nasopharyngitis

            Throat irritation

            Influenza

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            Warnings

            Contraindications

            Hypersensitivity

            Cautions

            May cause epistaxis, nasal ulceration, or nasal septal perforation

            Avoid with nasal disease other than allergic rhinitis

            May impair mental/physical abilities required for hazardous tasks (eg, driving, operating machinery)

            Avoid concurrent use of alcohol or other CNS depressants (possible additive sedation)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Unknown whether distributed in breast milk, caution advised

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Antihistamine (H1 antagonist); inhibits release of histamine from mast cells.

            Pharmacokinetics

            Half-Life: 8-12 hr

            Onset of action: 30 min (seasonal allergy)

            Absorption: Systemic 57%

            Bioavailability 57%

            Peak Plasma Time: 0.25-2 hr

            Peak Plasma Concentration: 23.3 ng/mL

            Protein Bound: 55% (predominantly albumin)

            Metabolites: N-desmethyl olopatadine; olopatadine N-oxide

            Metabolism: Liver; not extensive

            Excretion: Urine (60-70% unchanged); feces (17%)

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            Administration

            Intranasal Administration

            Prime nasal spray before initial use and when not in use for >7 days

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.