glycerin rectal (OTC)

Frequency Not Defined

Burning sensation

Cramping pain

Rectal irritation

Tenesmus

Contraindications

GI obstruction, severe impaction

Cautions

Do not use when abdominal pain, nausea, or vomiting present (unless directed by physician)

Frequent or prolonged use of laxatives may result in dependence

Rectal bleeding or failure to have bowel movement requires physician care

Contact physician before use if experience sudden change in bowel habits that last >2 wk

Do not use for longer than 1 wk

If constipation continues after one week of use, contact your physician

Contact physician if no bowel movement within 1 hr of using this product

Keep out of reach of children; if swallowed accidentally, get medical help or contact poison control center right away

Pregnancy category: Data not available

Lactation: Unknown, but probably compatible with breastfeeding

Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Mechanism of Action

Hyperosmotic dehydrating agent; draws fluid into colon, increases osmotic pressure, and stimulates evacuation

Pharmacokinetics

Onset of action: 15-30 min

Absorption: Poorly absorbed

Rectal Administration

For rectal use only

Insert 1 suppository well into the rectum and retain for 15 minutes; it need not melt to produce laxative action’ do not exceed 1 suppository daily or as directed by a doctor

Children 2 to <6 years: Use child suppositories

Children <2 years: Ask a doctor