diphtheria & tetanus toxoids/ acellular pertussis vaccine/poliovirus vaccine inactivated/hepatitis b vaccine (Rx)

Brand and Other Names:Pediarix, DTaP/ IPV/ HepB, more...DTaP/hepatitis B/inactivated poliovirus vaccine
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Dosing & Uses

AdultPediatric

Safety & efficacy not established

Dosage Forms & Strengths

Lf = limits of flocculation

(diphtheria toxoid/tetanus toxoid/inactivated pertussis toxin (PT)/ filamentous hemagglutinin (FHA)/pertactin/hepatitis B surface antigen (HBsAg)/type 1 poliovirus/type 2 poliovirus/type 3 poliovirus)/0.5 mL.

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Injection Suspension

(25 Lf/10 Lf/25 mcg/25 mcg/8 mcg/10 mcg/40 D-antigen units/8 D-antigen units/32 D-antigen units)/0.5 mL.

Immunization

Diphtheria, tetanus, pertussis, hepatitis B, & polio (poliovirus types 1, 2, 3)

<6 weeks: Not recommended

6 weeks-7 years: 0.5 mL IM x 3 doses starting at 6-8 weeks old, then 4 months and last dose at 6 months

Administer no sooner than every 4 weeks

Administration

< 1 years: Anterolateral thigh

>1 years: Deltoid muscle

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Interactions

Interaction Checker

and diphtheria & tetanus toxoids/ acellular pertussis vaccine/poliovirus vaccine inactivated/hepatitis b vaccine

No Results

     activity indicator 
    No Interactions Found
    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Suspected adverse events after administration of any vaccine may be reported to Vaccine Adverse Events Reporting System (VAERS), 1-800-822-7967

            >10%

            Irritability/fussiness (61-65%)

            Drowsiness (41-57%)

            Fever (28-39%)

            Loss of appetite (26-31%)

            Swelling (17-29%)

            1-10%

            Fever (≤1%)

            <1%

            Anorexia

            Apnea

            Erythema

            Decreased consciousness

            Diarrhea

            Hypotonia

            Encephalitis

            Brachial neuritis

            Erythema

            Peripheral neuropathy

            Cough

            Lethargy

            Limb pain

            Liver function test abnormalities

            Rash

            Restlessness

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            Warnings

            Contraindications

            Hypersensitivity to any component (including yeast, neomycin, polymyxin B)

            History of Arthus reaction to prior tetanus vaccination (unless 10 yr have elapsed)

            History of encephalopathy (within 7 days of administration not attributable to other causes), progressive neurologic disorder with pertussis-containing vaccine

            Progressive neurologic disorder

            Infantile spasms, uncontrolled epilepsy, progressive encephalopathy

            Do not administer pertussis vaccine until neurologic status is stabilized

            Cautions

            Associated with higher rates of fever than separately administered vaccines

            Apnea reported in premature infants following IM vaccine administration

            Tetanus toxoid carries risk for brachial neuritis, Guillain-Barre syndrome and anaphylaxis

            Caution in Guillain-Barre syndrome within 6 wk of prior tetanus toxoid vaccine

            Syncope accompanied by transient disturbances, tonic-clonic movements, or weakness reported

            Consider postponing administration iin patients with moderate or severe acute illness (with or without fever)

            Use caution in patients with a history of bleeding disorders (including thrombocytopenia) and or patients on anticoagulants

            Use caution in severely immunocompromised patients

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: Not indicated for women of childbearing age

            Pregnancy Categories

            A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA:Information not available.

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            Pharmacology

            Mechanism of Action

            Production of specific antibodies to tetanus, diphtheria, and pertusis (active immunity)

            Conveys active immunity via stimulation of production of endogenously produced antibodies

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            Formulary

            FormularyPatient Discounts

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            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.