Dosing & Uses
Dosage Forms & Strengths
injectable solution
- 100mg Sb/mL
Leishmaniasis (Orphan)
20 mg Sb/kg/day (maximum 850 mg) IV/IM for 20-28 days
Available in the United States only from CDC
Acute Myeloid Leukemia (Orphan)
Orphan designation for treatment of acute myeloid leukemia (AML)
Sponsor
- BioXcel Corporation; 780 East Main Street, Suite 2; Branford, Connecticut 06405
Adverse Effects
Frequency Not Defined
Anorexia
Nausea/vomiting
Abdominal pain
ECG changes
Headache
Lethargy
Myalgia
Raised liver enzymes
Coughing and substernal pain
Anaphylaxis (rare)
Fever
Sweating
Flushing
Vertigo
Bleeding from nose or gum
Jaundice
Rash
Pain and thrombosis on intravenous administration, intramuscular injection also painful
Warnings
Contraindications
Hypersensitivity
Significant renal impairment; breast-feeding
Pregnancy & Lactation
Pregnancy Category: unknown
Lactation: unknown
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Reduction in the fructose diphosphate and an inhibition of glycolysis
Pharmacokinetics
Metabolism: unknown
Excretion: unknown
Images
Formulary
Adding plans allows you to compare formulary status to other drugs in the same class.
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Adding plans allows you to:
- View the formulary and any restrictions for each plan.
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- Compare formulary status to other drugs in the same class.
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