Dosing & Uses
Dosage Forms & Strengths
oral solution
- 0.12%
chip
- 2.5mg
Gingivitis
Peridex, PerioGard: PO rinse 15 mL q12hr
Adjunct to Scaling & Root Planing
PerioChip: 1-8 chips in periodontal pocket, depth >5 mm; repeat q3Months
Oral Mucositis (Orphan)
Amelioration of oral mucositis associated with cytoreductive therapy used in conditioning patients for bone marrow transplantation therapy
Orphan indication sponsor
- Procter & Gamble Company; Sharon Wood Technical Center, 11370 Reed Hartman Highway; Cincinnati, OH 45241
Safety and efficacy not established
Interactions
Interaction Checker
No Results
Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor
Contraindicated (1)
- allogeneic cultured keratinocytes/fibroblasts in bovine collagen
chlorhexidine oral decreases effects of allogeneic cultured keratinocytes/fibroblasts in bovine collagen by Other (see comment). Contraindicated. Comment: Exposure to topical antiseptics has been shown to degrade Gintuit; if exposed, irrigate the wound thoroughly with saline and allow a suitable wash-out period to elapse before applying Gintuit.
Serious - Use Alternative (2)
- BCG vaccine live
chlorhexidine oral decreases effects of BCG vaccine live by pharmacodynamic antagonism. Contraindicated. Wait until Abx Tx complete to administer live bacterial vaccine.
- typhoid vaccine live
chlorhexidine oral decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Contraindicated. Wait until Abx Tx complete to administer live bacterial vaccine.
Monitor Closely (7)
- bazedoxifene/conjugated estrogens
chlorhexidine oral will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.
- conjugated estrogens
chlorhexidine oral will decrease the level or effect of conjugated estrogens by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.
- digoxin
chlorhexidine oral will increase the level or effect of digoxin by altering intestinal flora. Applies only to oral form of both agents. Use Caution/Monitor.
- estradiol
chlorhexidine oral will decrease the level or effect of estradiol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.
- estrogens conjugated synthetic
chlorhexidine oral will decrease the level or effect of estrogens conjugated synthetic by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.
- estropipate
chlorhexidine oral will decrease the level or effect of estropipate by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.
- mestranol
chlorhexidine oral will decrease the level or effect of mestranol by altering intestinal flora. Applies only to oral forms of hormone. Low risk of contraceptive failure. Use Caution/Monitor.
Minor (7)
- balsalazide
chlorhexidine oral will decrease the level or effect of balsalazide by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- biotin
chlorhexidine oral will decrease the level or effect of biotin by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- pantothenic acid
chlorhexidine oral will decrease the level or effect of pantothenic acid by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- pyridoxine
chlorhexidine oral will decrease the level or effect of pyridoxine by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- pyridoxine (Antidote)
chlorhexidine oral will decrease the level or effect of pyridoxine (Antidote) by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- thiamine
chlorhexidine oral will decrease the level or effect of thiamine by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
- vitamin K1 (phytonadione)
chlorhexidine oral will decrease the level or effect of vitamin K1 (phytonadione) by altering intestinal flora. Applies only to oral form of both agents. Minor/Significance Unknown.
Adverse Effects
>10%
Increased tartar on teeth
1-10%
Skin and oral irritation
Staining of tooth
Bronchitis
Taste sense altered
Toothache
Increase in calculus formation
<1%
Stomatitis
Gingivitis
Glossitis
Aphthous ulcer
Dry mouth
Hypesthesia
Glossal edema, and paresthesia
Grossly obvious gingivitis
Desquamation
Coated tongue
Keratinization
Geographic tongue
Mucocele
Anaphylaxis
Warnings
Contraindications
Hypersensitivity
Cautions
Serious allergic reactions reported, including anaphylaxis that can occur within minutes presenting as wheezing, difficulty breathing, facial edema, hives, severe rash, or hypotension and shock
Extended-release pellets: Anaphylaxis and serious allergic reactions reported during postmarketing surveillance
Increase of tartar on teeth
Changes in taste
Staining of oral surfaces (mucosa, teeth, dorsum of tongue) may be visible as soon as 1wk after therapy begins and is more pronounced when there is a heavy accumulation of unremoved plaque and when teeth fillings have rough surfaces; stain does not have a clinically adverse effect but because removal may not be possible, patient with frontal restoration should be advised of the potential permanency of the stain
Pregnancy & Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown; use with caution
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Polybiguanide antiseptic and antimicrobial drug with bactericidal activity; binds to the negatively charged bacterial cell walls and extramicrobial complexes
Pharmacokinetics
Absorption: ~30% retained in the oral cavity following rinsing and slowly released into oral fluids; poorly absorbed
Time to peak, plasma: Oral rinse: Detectable levels not present after 12 hr
Excretion: Feces (~90%); urine (<1%)
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