pyrantel pamoate (Rx)

Brand and Other Names:Pin Rid, Pin X
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral suspension

  • 250mg/5mL (as base)

capsule

  • 180mg (equivalent to 62.5mg base)

chewable tablet

  • 720.5mg (equivalent to 250mg base)

Ascariasis (Roundworm)

11 mg (base)/kg PO qDay x 3 days; not to exceed 1 g/dose  

Enterobius (Pinworm)

Drug label recommendation

  • 11 mg/kg PO once; do not repeat dose unless directed by a physician; not to exceed 1 g/dose  

CDC recommended dose

  • 11 mg (base)/kg PO q2week x2 doses; not to exceed 1 g/dose

Eosinophilic Enterocolitis (Hookworm; Off-label)

11 mg (base)/kg PO qDay x3 days; not to exceed 1 g/dose  

Moniliformis (Off-label)

11 mg/kg PO once; may repeat after 14 days

Administration

May take with food

Dosage Forms & Strengths

oral suspension

  • 250mg/5mL (as base)

capsule

  • 180mg (equivalent to 62.5mg base)

chewable tablet

  • 720.5mg (equivalent to 250mg base)

Ascariasis (Roundworm)

<2 years: Safety and efficacy not established

>2 years: 11 mg (base)/kg PO x 1 dose; not to exceed 1 g/dose  

Enterobius (Pinworm)

<2 years: Safety and efficacy not established

>2 years: 11 mg (base)/kg PO q2week x 2 doses; not to exceed 1 g/dose  

Eosinophilic Enterocolitis (Hookworm; Off-label)

<2 years: Safety and efficacy not established

>2 years: 11 mg (base)/kg PO qDay x 3 days; not to exceed 1 g/dose  

Moniliformis (Off-label)

11 mg/kg PO once; may repeat after 14 days

Administration

May take with food

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Interactions

Interaction Checker

and pyrantel pamoate

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Contraindicated (0)

              Serious - Use Alternative (0)

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                  Minor (2)

                  • piperazine

                    pyrantel pamoate, piperazine. Either decreases effects of the other by pharmacodynamic antagonism. Minor/Significance Unknown.

                  • theophylline

                    pyrantel pamoate increases levels of theophylline by unspecified interaction mechanism. Minor/Significance Unknown.

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                  Adverse Effects

                  Frequency Not Defined

                  Dizziness

                  Drowsiness

                  Insomnia

                  Headache

                  Rash

                  Anorexia

                  Nausea

                  Vomiting

                  Abdominal cramps

                  Diarrhea

                  Tenesmus

                  Elevated LFTs

                  Weakness

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                  Warnings

                  Contraindications

                  Hypersensitivity

                  Intestinal obstruction

                  Hepatic disease

                  Cautions

                  Caution in anemia, hepatic impairment, malnutrition

                  Some products may contain sodium benzoate

                  Treat all family members in close contact with the patient (infection easily spread)

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                  Pregnancy & Lactation

                  Pregnancy Category: C

                  Lactation: unknown

                  Pregnancy Categories

                  A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

                  B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

                  C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

                  D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

                  X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

                  NA: Information not available.

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                  Pharmacology

                  Mechanism of Action

                  Depolarizing neuromuscular blocker, inhibits cholinesterases, causing spastic paralysis of the helminths

                  Pharmacokinetics

                  Absorption: Poor

                  Metabolism: Partially hepatic

                  Peak Plasma Time: 1-3 hr

                  Excretion: feces (50%); urine (7%)

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                  Images

                  BRAND FORM. UNIT PRICE PILL IMAGE
                  Reese's Pinworm Medicine oral
                  -
                  50 mg/mL suspension
                  Reese's Pinworm Medicine oral
                  -
                  50 mg/mL suspension

                  Copyright © 2010 First DataBank, Inc.

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                  Patient Handout

                  Patient Education
                  pyrantel pamoate oral

                  PYRANTEL SUSPENSION - ORAL

                  (pi-RAN-tel)

                  COMMON BRAND NAME(S): Pin-X

                  USES: This medication is used to treat intestinal worm infections such as pinworm, roundworm, and hookworm. Pyrantel belongs to a class of drugs known as anthelmintics. It works by making the worms unable to move (paralyzed) so that the body can remove them naturally in the stool.This medication may be used to self-treat pinworm infections. For other types of worm infections (such as roundworm, hookworm), use this product only as directed by your doctor. Do not use this medication in children younger than 2 years unless directed by the doctor.

                  HOW TO USE: If you are taking the over-the-counter product, read all directions on the product package before taking this medication. This medicine comes with a Patient Information Leaflet. Read it carefully. Be sure you understand how to identify pinworms, understand the symptoms of pinworm infections, and how to prevent becoming infected again. If you have any questions, consult your doctor or pharmacist.Shake the medication well before using. Take this medication by mouth with or without food or as directed by your doctor.Take this medication by mouth with or without food, usually once as a single dose or as directed by your doctor. This medication may be taken with milk or fruit juice. It is not necessary to take a laxative with this medication.Dosage is based on your weight, type of infection, and response to treatment. Do not take more than a total of 1 gram in a single dose. If you are self-treating for pinworms, take the medication once only. Do not repeat the dose without talking with your doctor first. Depending on the type of worm infection you have, your doctor may direct you to take the medication only once or for several days. Your doctor may also direct you to repeat the dose in 2 weeks.If you continue to see worms in your stool or if symptoms persist or worsen, or if you think you may have a different type of worm infection or a serious medical problem, seek immediate medical attention.

                  SIDE EFFECTS: Nausea, vomiting, diarrhea, stomach/abdominal cramps, headache, drowsiness, dizziness, trouble sleeping, or loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

                  PRECAUTIONS: Before taking pyrantel, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, severe lack of nutrition (malnutrition), anemia.This drug may rarely make you drowsy or dizzy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. If you are pregnant, do not use this medication to treat yourself without first consulting your doctor.It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

                  DRUG INTERACTIONS: The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.If you are taking this medication under your doctor's direction, to help your doctor or pharmacist give you the best care, be sure to tell your doctor or pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.Keep a list of all the products you use. Share the list with your doctor and pharmacist to reduce your risk for serious medication problems.

                  OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe muscle spasms/twitching/weakness or severe trouble breathing.

                  NOTES: Some types of worm infections can be easily spread among family members or people living within the same household. It is important for family members to be checked even if they do not have symptoms. To keep from being infected again, everyone in the household may need to be treated. Also, thoroughly clean the home and all clothing, and be very careful with personal hygiene. Wash hands frequently and keep fingernails trimmed. Consult your doctor or pharmacist for details.If your doctor has directed you to use this medication, use it for your current condition only. Do not use it later for another infection unless your doctor tells you to.

                  MISSED DOSE: If your doctor has directed you to use more than one dose and you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.

                  STORAGE: Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

                  Information last revised August 2021. Copyright(c) 2021 First Databank, Inc.

                  IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs.

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                  Formulary

                  FormularyPatient Discounts

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                  The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

                  Tier Description
                  1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
                  2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
                  3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
                  4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
                  NC NOT COVERED – Drugs that are not covered by the plan.
                  Code Definition
                  PA Prior Authorization
                  Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
                  QL Quantity Limits
                  Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
                  ST Step Therapy
                  Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
                  OR Other Restrictions
                  Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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                  Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.