pyrantel pamoate (Rx)

Brand and Other Names:Pin Rid, Pin X
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

oral suspension

  • 250mg/5mL (as base)

capsule

  • 180mg (equivalent to 62.5mg base)

chewable tablet

  • 720.5mg (equivalent to 250mg base)

Ascariasis (Roundworm)

11 mg (base)/kg PO qDay x 3 days; not to exceed 1 g/dose  

Enterobius (Pinworm)

Drug label recommendation

  • 11 mg/kg PO once; do not repeat dose unless directed by a physician; not to exceed 1 g/dose  

CDC recommended dose

  • 11 mg (base)/kg PO q2week x2 doses; not to exceed 1 g/dose

Eosinophilic Enterocolitis (Hookworm; Off-label)

11 mg (base)/kg PO qDay x3 days; not to exceed 1 g/dose  

Moniliformis (Off-label)

11 mg/kg PO once; may repeat after 14 days

Administration

May take with food

Dosage Forms & Strengths

oral suspension

  • 250mg/5mL (as base)

capsule

  • 180mg (equivalent to 62.5mg base)

chewable tablet

  • 720.5mg (equivalent to 250mg base)

Ascariasis (Roundworm)

<2 years: Safety and efficacy not established

>2 years: 11 mg (base)/kg PO x 1 dose; not to exceed 1 g/dose  

Enterobius (Pinworm)

<2 years: Safety and efficacy not established

>2 years: 11 mg (base)/kg PO q2week x 2 doses; not to exceed 1 g/dose  

Eosinophilic Enterocolitis (Hookworm; Off-label)

<2 years: Safety and efficacy not established

>2 years: 11 mg (base)/kg PO qDay x 3 days; not to exceed 1 g/dose  

Moniliformis (Off-label)

11 mg/kg PO once; may repeat after 14 days

Administration

May take with food

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Interactions

Interaction Checker

and pyrantel pamoate

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    Interactions Found

    Contraindicated

      Serious - Use Alternative

        Significant - Monitor Closely

          Minor

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            Adverse Effects

            Frequency Not Defined

            Dizziness

            Drowsiness

            Insomnia

            Headache

            Rash

            Anorexia

            Nausea

            Vomiting

            Abdominal cramps

            Diarrhea

            Tenesmus

            Elevated LFTs

            Weakness

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            Warnings

            Contraindications

            Hypersensitivity

            Intestinal obstruction

            Hepatic disease

            Cautions

            Caution in anemia, hepatic impairment, malnutrition

            Some products may contain sodium benzoate

            Treat all family members in close contact with the patient (infection easily spread)

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            Pregnancy & Lactation

            Pregnancy Category: C

            Lactation: unknown

            Pregnancy Categories

            A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

            B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

            C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

            D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

            X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

            NA: Information not available.

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            Pharmacology

            Mechanism of Action

            Depolarizing neuromuscular blocker, inhibits cholinesterases, causing spastic paralysis of the helminths

            Pharmacokinetics

            Absorption: Poor

            Metabolism: Partially hepatic

            Peak Plasma Time: 1-3 hr

            Excretion: feces (50%); urine (7%)

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            Formulary

            FormularyPatient Discounts

            Adding plans allows you to compare formulary status to other drugs in the same class.

            To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

            Adding plans allows you to:

            • View the formulary and any restrictions for each plan.
            • Manage and view all your plans together – even plans in different states.
            • Compare formulary status to other drugs in the same class.
            • Access your plan list on any device – mobile or desktop.

            The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

            Tier Description
            1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
            2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
            3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
            4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
            NC NOT COVERED – Drugs that are not covered by the plan.
            Code Definition
            PA Prior Authorization
            Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
            QL Quantity Limits
            Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
            ST Step Therapy
            Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
            OR Other Restrictions
            Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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            Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.