podophyllum resin (Rx)

Brand and Other Names:
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

solution

  • 25%

Condyloma Acuminata

Thoroughly cleanse area

Use supplied aplicator to apply thoroughly to lesion; allow to dry thoroughly; leave first application in contact for only a few minutes (30-40 min) to test for sensitivity

Leave on subsequent applications for 1-4 hr depending on condition of lesion and patient

Protect adjacent normal skin with petrolatum

Remove dried podophyllin thoroughly with alcohol or soap and water after treatment time has elapsed

Dosage Forms & Strengths

solution

  • 25%

Condyloma Acuminata

Thoroughly cleanse area

Use supplied aplicator to apply thoroughly to lesion; allow to dry thoroughly; leave first application in contact for only a few minutes (30-40 min) to test for sensitivity

Leave on subsequent applications for 1-4 hr depending on condition of lesion and patient

Protect adjacent normal skin with petrolatum

Remove dried podophyllin thoroughly with alcohol or soap and water after treatment time has elapsed

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Adverse Effects

Frequency Not Defined

Local

  • Severe necrosis/scarring of the anogenital area
  • Paraphimosis
  • Pseudoepitheliomatous hyperplasia

Systemic

  • Urticaria
  • Fever
  • Paresthesia
  • Polyneuritis
  • Paralytic ileus
  • Pyrexia leukopenia
  • Thrombocytopenia
  • Coma
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Warnings

Contraindications

Hypersensitivity

Avoid EtOH for several hours after treatment

Mucosal tissue, moles, birthmarks, large/extensive genital warts, bleeding warts

Avoid in patients with diabetes or circulatory problems

Breast feeding

Cautions

Only to be applied by doctor

Limit application to small area of intact skin

Avoid eyes; may cause corneal damage

Use not recommeded if wart or surrounding tissue inflamed/irritated

Use of large amounts of the product not recommended

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Pregnancy & Lactation

Pregnancy Category: X; not recommended

Lactation: Unknown; avoid during breastfeeding

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Formulary

FormularyPatient Discounts

Adding plans allows you to compare formulary status to other drugs in the same class.

To view formulary information first create a list of plans. Your list will be saved and can be edited at any time.

Adding plans allows you to:

  • View the formulary and any restrictions for each plan.
  • Manage and view all your plans together – even plans in different states.
  • Compare formulary status to other drugs in the same class.
  • Access your plan list on any device – mobile or desktop.

The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.