prednisolone/gentamicin ophthalmic (Rx)

Brand and Other Names:Pred G
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Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

prednisolone/gentamicin

ophthalmic suspension

  • 1%/0.3%

ophthalmic ointment

  • 0.6%/0.3%

Ocular Anti-inflammatory/Anti-infective

Ophthalmic ointment

  • Apply to conjunctival sac of affected eye qDay to q8hr
  • Re-evaluate patient if no improvement after 2 days of therapy

Ophthalmic suspension

  • 1 gtt q6-12hr (up to q1hr during initial 24-48 hr of treatment); may increase dosing frequency to q1hr if necessary
  • Re-evaluate patient if no improvement after 2 days of therapy

Safety & efficacy not established

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Adverse Effects

Frequency Not Defined

Ocular discomfort

Irritation upon instillation

Punctate keratitis

Elevation of IOP with possible development of glaucoma

Optic nerve damage

Posterior subcapsular cataract formation

Delayed wound healing

Secondary infection

Fungal infections of the cornea

Allergic sensitizations

Rash

Superinfection (herpes)

Postmarketing Reports

Eye burning

Eye stinging

Ocular hyperemia

Eye pain

Eye discharge

Lacrimation increased

Eye edema

Visual impairment

Foreign body sensation in eyes

Dysgeusia

Blurry vision

Hypersensitivity including signs and symptoms related to ocular allergy (e.g. conjunctivitis), angioedema (e.g. tongue edema) and allergic skin reactions (e.g. rash and contact allergy)

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Warnings

Contraindications

Hypersensivity to any component

Glaucoma, viral diseases of cornea & conjunctiva (epithelial herpes simplex keratitis, vaccinia, varicella), mycobacterial eye infection & fungal diseases of ocular structures

Cautions

Bacterial keratitis reported from inadvertent contamination of multiple dose ophthalmic solution Immunosuppression resulting from prolonged use of steroid use may result in secondary bacterial and fungal infections; steroids may also mask symptoms of infections and enhance existing ocular infections

Ocular hypertension and/or glaucoma reported with prolonged corticosteroid use

Corticosteroid and gentamicin use following cataract surgery may delay healing

Discontinue use if sensitivity reaction to gentamicin develops

Prolonged gentmicin use may result in fungal or bacterial superinfection

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Pregnancy & Lactation

Pregnancy: C

Lactation: Unknown whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human milk; systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause untoward effects

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

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Pharmacology

Mechanism of Action

Prednisolone prevents/reduces irritation & swelling by suppressing normal immune response, decreasing inflammatory mediators and reverses capillary permeability

Gentamicin alters bacterial cell membrane integrity by binding to 30S and 50S ribosomal subunits, which in turn interferes with bacterial protein synthesis

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Images

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Formulary

FormularyPatient Discounts

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The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

Tier Description
1 This drug is available at the lowest co-pay. Most commonly, these are generic drugs.
2 This drug is available at a middle level co-pay. Most commonly, these are "preferred" (on formulary) brand drugs.
3 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs.
4 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
5 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
6 This drug is available at a higher level co-pay. Most commonly, these are "non-preferred" brand drugs or specialty prescription products.
NC NOT COVERED – Drugs that are not covered by the plan.
Code Definition
PA Prior Authorization
Drugs that require prior authorization. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
QL Quantity Limits
Drugs that have quantity limits associated with each prescription. This restriction typically limits the quantity of the drug that will be covered.
ST Step Therapy
Drugs that have step therapy associated with each prescription. This restriction typically requires that certain criteria be met prior to approval for the prescription.
OR Other Restrictions
Drugs that have restrictions other than prior authorization, quantity limits, and step therapy associated with each prescription.
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Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature.