Dosing & Uses
Dosage Forms & Strengths
dental cream
- 1.1% as sodium
dental gel
- 1.1% as sodium
- 0.4% as stannous fluoride
dental paste
- 1.1% as sodium
liquid, base
- 0.125 mg/drop
solution
- 0.02% as fluoride
- 0.2% as sodium
drops
- 1.1 mg/mL as sodium (equivalent to fluoride 0.5 mg/mL)
lozenge
- 2.21 mg (equivalent to 1 mg fluoride)
Dental Caries Prevention
Dental Gel/Cream
- Apply thin ribbon to toothbrush; brush thoroughly qDay at bedtime for 2 minutes
- Expectorate after brushing; for best results do not eat, drink, or rinse mouth for 30 minutes
Dental Rinse
- 5-10 mL PO qDay or q12hr; swish for 1 minute, then expectorate
- Use immediately after brushing/flossing teeth
- Avoid eating, drinking, or rinsing your mouth for at least 30 minutes after using this to enable the medication to have contact with the teeth
Lozenge
- 1 lozenge qDay
Dosage Forms & Strengths
dental cream
- 1.1%
dental gel
- 1.1% as sodium
- 0.4% as stannous fluoride
solution
- 0.02% as fluoride
- 0.2% as sodium
Dental Caries Prevention
Infants and young children <6 years: Safety and efficacy not established
May be prescribed for older children and adolescents undergoing orthodontia
Dental Gel/Cream
- Apply thin ribbon to toothbrush; brush thoroughly qDay at bedtime for 2 minutes
- Pediatric patients aged 6-16 years: Expectorate after brushing, and rinse mouth thoroughly; for best results do not eat or drink for 30 minutes
Dental Rinse
- 5-10 mL PO qDay or q12hr; swish for 1 minute, then expectorate
- Use immediately after brushing/flossing teeth
- Do not swallow rinse unless directed by your doctor or dentist
- Avoid eating, drinking, or rinsing your mouth for at least 30 minutes after using this to enable the medication to have contact with the teeth
Adverse Effects
Frequency Not Defined
Sialorrhea
Mouth/gum irritation
Nausea, vomiting, stomach pain, diarrhea, headache, muscle tremor (if accidentally swallowed)
Discoloration of teeth (rare)
Warnings
Contraindications
Hypersensitivity
1 mg/5mL rinse in children < 6 years
Low sodium or sodium free diets
Drinking water fluoride content ≥ 0.7 ppm
Cautions
Not for systemic use; do not swallow
Continuous ingestion may result in fluoride toxicity; particularly in young children and if water fluoridation exceeds 0.6 ppm (dental fluorosis or osseous changes may occur)
Caution with kidney disease, peptic ulcer disease, severe joint pain, or low-sodium diet
Supervise use in children; do not use in children unable to expectorate content
Some products may contain tartrazine
Pregnancy & Lactation
Pregnancy Category: B; heavy in utero exposure to fluoride may cause skeletal fluorosis
Lactation: Distributed in breast milk
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Provides fluorosis; frequent topical applications of high fluoride content to the teeth increases tooth resistance to acid dissolution and enhance penetration of the fluoride ion into tooth enamel
Pharmacokinetics
Absorption: Rapid and complete
Distribution: 50% deposited in teeth and bone after ingestion
Excretion: Urine and feces
Images
Formulary
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