Dosing & Uses
Dosage Forms & Strengths
suspension for aerosol inhalation
- 0.125mg/actuation
Mild Asthma
Indicated for temporary relief of mild symptoms of intermittent asthma (eg, wheezing, chest tightness, dyspnea)
1-2 inhalations PO q4hr PRN; start with 1 inhalation, wait at least 1 minute, administer second inhalation if symptoms not relieved
Not to exceed 8 inhalations/24 hr
Dosage Forms & Strengths
suspension for aerosol inhalation
- 0.125mg/actuation
Mild Asthma
Indicated for temporary relief of mild symptoms of intermittent asthma (eg, wheezing, chest tightness, dyspnea)
<12 years: Safety and efficacy not established
≥12 years
- 1-2 inhalations PO q4hr PRN; start with 1 inhalation, wait at least 1 minute, administer second inhalation if symptoms not relieved
- Not to exceed 8 inhalations/24 hr
Interactions
Interaction Checker
No Results

Contraindicated
Serious - Use Alternative
Significant - Monitor Closely
Minor

Adverse Effects
Frequency Not Defined
Tachycardia
Increased blood pressure
Warnings
Contraindications
Undiagnosed pulmonary symptoms
Coadministration with MAOIs, or within 2 weeks after discontinuing an MAOI
Cautions
Patients who have severe asthma or who have been hospitalized for asthma should seek medical attention for prescription medications to treat their asthma
Caution with preexisting conditions, including heart disease (eg, arrhythmias, coronary insufficiency, elevated blood pressure [BP]), diabetes, urinary impairment, enlarged prostate, thyroid disease, seizures, or narrow-angle glaucoma
May increase heart rate (HR) or BP
Not for relief of COPD symptoms
Drug interaction overview
- Coadministration with MAOIs or within 2 weeks after discontinuing an MAOI is contraindicated, owing to risk for hypertensive episode
- Tricyclic antidepressants may potentiate epinephrine effect on cardiovascular system
- Other stimulants (eg, phenylephrine, pseudoephedrine, ephedrine, caffeine) may have additive effects on HR or BP
- Caution with beta-blockers; may block bronchodilatory effects of epinephrine
Pregnancy & Lactation
Pregnancy
Control of asthma during pregnancy is essential for maternal and fetal health
In women with poorly or moderately controlled asthma, there is increased risk of preeclampsia in mother and prematurity, low birth weight, and small for gestational age in neonate; pregnant women should be closely monitored and medication adjusted as necessary to maintain optimal control
Beta-agonists may interfere with uterine contractility during labor
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Lactation
Unknown if inhaled epinephrine is distributed in human milk
Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs
Pregnancy Categories
A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.
B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.Pharmacology
Mechanism of Action
Elicits beta1- and beta2-adrenergic effects, resulting in bronchial smooth muscle relaxation
Also has alpha-adrenergic effects that may increase HR and BP
Administration
Inhaled Administration
For oral inhalation only
Before first use only: Shake inhaler and spray into air; repeat both actions 4 times to assure inhaler is activated
Before subsequent doses (ie, 1-2 inhalations): Shake inhaler then spray into air once to prime
After each day of use: Wash by removing red cap and container; run water through mouthpiece for 30 seconds, then shake off excess water and let dry
Storage
Store at room temperature between 15-25°C (59-77°F)
Do not store near open flame